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Review
Host–microbial interactions in metabolic diseases: from diet to immunity
Ju-Hyung Lee , Joo-Hong Park
J. Microbiol. 2022;60(6):561-575.   Published online May 5, 2022
DOI: https://doi.org/10.1007/s12275-022-2087-y
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  • 5 Web of Science
  • 4 Crossref
AbstractAbstract
Growing evidence suggests that the gut microbiome is an important contributor to metabolic diseases. Alterations in microbial communities are associated with changes in lipid metabolism, glucose homeostasis, intestinal barrier functions, and chronic inflammation, all of which can lead to metabolic disorders. Therefore, the gut microbiome may represent a novel therapeutic target for obesity, type 2 diabetes, and nonalcoholic fatty liver disease. This review discusses how gut microbes and their products affect metabolic diseases and outlines potential treatment approaches via manipulation of the gut microbiome. Increasing our understanding of the interactions between the gut microbiome and host metabolism may help restore the healthy symbiotic relationship between them.

Citations

Citations to this article as recorded by  
  • Fecal Microbiota Transplantation: Indications, Methods, and Challenges
    Jee Young Lee, Yehwon Kim, Jiyoun Kim, Jiyeun Kate Kim
    Journal of Microbiology.2024; 62(12): 1057.     CrossRef
  • Galectin-4 increases the ability of M2 macrophages to enhance antiviral CD4+ T-cell responses
    In-Gu Lee, Yong-Hyun Joo, Hoyeon Jeon, Raehyuk Jeong, Eui Ho Kim, Hyunwoo Chung, Seong-il Eyun, Jeongkyu Kim, Young-Jin Seo, So-Hee Hong
    Journal of Leukocyte Biology.2023; 113(1): 71.     CrossRef
  • Microencapsulation of Bacteriophages for the Delivery to and Modulation of the Human Gut Microbiota through Milk and Cereal Products
    Christina Schubert, Sabina Fischer, Kathrin Dorsch, Lutz Teßmer, Jörg Hinrichs, Zeynep Atamer
    Applied Sciences.2022; 12(13): 6299.     CrossRef
  • Beta-Glucan Alters Gut Microbiota and Plasma Metabolites in Pre-Weaning Dairy Calves
    Zhengzhong Luo, Li Ma, Tao Zhou, Yixin Huang, Liben Zhang, Zhenlong Du, Kang Yong, Xueping Yao, Liuhong Shen, Shumin Yu, Xiaodong Shi, Suizhong Cao
    Metabolites.2022; 12(8): 687.     CrossRef
Journal Article
Characterization of the velvet regulators in Aspergillus flavus
Tae-Jin Eom , Heungyun Moon , Jae-Hyuk Yu , Hee-Soo Park
J. Microbiol. 2018;56(12):893-901.   Published online October 25, 2018
DOI: https://doi.org/10.1007/s12275-018-8417-4
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  • 32 Crossref
AbstractAbstract
Fungal development and secondary metabolism are closely associated via the activities of the fungal NK-kB-type velvet regulators that are highly conserved in filamentous fungi. Here, we investigated the roles of the velvet genes in the aflatoxigenic fungus Aspergillus flavus. Distinct from other Aspergillus species, the A. flavus genome contains five velvet genes, veA, velB, velC, velD, and vosA. The deletion of velD blocks the production of aflatoxin B1, but does not affect the formation of sclerotia. Expression analyses revealed that vosA and velB mRNAs accumulated at high levels during the late phase of asexual development and in conidia. The absence of vosA or velB decreased the content of conidial trehalose and the tolerance of conidia to the thermal and UV stresses. In addition, double mutant analyses demonstrated that VosA and VelB play an inter-dependent role in trehalose biosynthesis and conidial stress tolerance. Together with the findings of previous studies, the results of the present study suggest that the velvet regulators play the conserved and vital role in sporogenesis, conidial trehalose biogenesis, stress tolerance, and aflatoxin biosynthesis in A. flavus.

Citations

Citations to this article as recorded by  
  • Data-Independent Acquisition Proteome Technology for Analysis of Antifungal and Anti-aflatoxigenic Properties of Eugenol to Aspergillus flavus
    Xinyue Zhang, Wenjing Peng, Mumin Zheng, Bolei Yang, Bowen Tai, Xu Li, Fuguo Xing
    Journal of Agricultural and Food Chemistry.2024;[Epub]     CrossRef
  • Rhein Inhibits Cell Development and Aflatoxin Biosynthesis via Energy Supply Disruption and ROS Accumulation in Aspergillus flavus
    Xiaoyan Wang, Kashif Iqbal Sahibzada, Ruibo Du, Yang Lei, Shan Wei, Na Li, Yuansen Hu, Yangyong Lv
    Toxins.2024; 16(7): 285.     CrossRef
  • Involvement of LaeA and Velvet Proteins in Regulating the Production of Mycotoxins and Other Fungal Secondary Metabolites
    Xuwen Hou, Liyao Liu, Dan Xu, Daowan Lai, Ligang Zhou
    Journal of Fungi.2024; 10(8): 561.     CrossRef
  • SscA is required for fungal development, aflatoxin production, and pathogenicity in Aspergillus flavus
    Ye-Eun Son, Hee-Soo Park
    International Journal of Food Microbiology.2024; 413: 110607.     CrossRef
  • HacA, a key transcription factor for the unfolded protein response, is required for fungal development, aflatoxin biosynthesis and pathogenicity of Aspergillus flavus
    Min Yu, Xiaoling Zhou, Dongyue Chen, Yuan Jiao, Guomin Han, Fang Tao
    International Journal of Food Microbiology.2024; 417: 110693.     CrossRef
  • The Velvet transcription factor PnVeA regulates necrotrophic effectors and secondary metabolism in the wheat pathogen Parastagonospora nodorum
    Shota Morikawa, Callum Verdonk, Evan John, Leon Lenzo, Nicolau Sbaraini, Chala Turo, Hang Li, David Jiang, Yit-Heng Chooi, Kar-Chun Tan
    BMC Microbiology.2024;[Epub]     CrossRef
  • Beyond morphogenesis and secondary metabolism: function of Velvet proteins and LaeA in fungal pathogenesis
    Ana M. Calvo, Apoorva Dabholkar, Elizabeth M. Wyman, Jessica M. Lohmar, Jeffrey W. Cary, Yvonne Nygård
    Applied and Environmental Microbiology.2024;[Epub]     CrossRef
  • UvVelC is important for conidiation and pathogenicity in the rice false smut pathogen Ustilaginoidea virens
    Mina Yu, Tianqiao Song, Junjie Yu, Huijuan Cao, Xiayan Pan, Zhongqiang Qi, Yan Du, Wende Liu, Yongfeng Liu
    Virulence.2024;[Epub]     CrossRef
  • Advanced mycotoxin control and decontamination techniques in view of an increased aflatoxin risk in Europe due to climate change
    Martina Loi, Antonio F. Logrieco, Tünde Pusztahelyi, Éva Leiter, László Hornok, István Pócsi
    Frontiers in Microbiology.2023;[Epub]     CrossRef
  • Estragole Inhibits Growth and Aflatoxin Biosynthesis of Aspergillus flavus by Affecting Reactive Oxygen Species Homeostasis
    Liuke Liang, Wei Zhang, Jing Hao, Yanyu Wang, Shan Wei, Shuaibing Zhang, Yuansen Hu, Yangyong Lv, Xiaohui Zhou
    Microbiology Spectrum.2023;[Epub]     CrossRef
  • The novel spore-specific regulator SscA controls Aspergillus conidiogenesis
    Ye-Eun Son, Jae-Hyuk Yu, Hee-Soo Park, Gustavo H. Goldman
    mBio.2023;[Epub]     CrossRef
  • Light regulation of secondary metabolism in fungi
    Wenbin Yu, Rongqiang Pei, Yufei Zhang, Yayi Tu, Bin He
    Journal of Biological Engineering.2023;[Epub]     CrossRef
  • Regulation of Fungal Morphogenesis and Pathogenicity of Aspergillus flavus by Hexokinase AfHxk1 through Its Domain Hexokinase_2
    Zongting Huang, Dandan Wu, Sile Yang, Wangzhuo Fu, Dongmei Ma, Yanfang Yao, Hong Lin, Jun Yuan, Yanling Yang, Zhenhong Zhuang
    Journal of Fungi.2023; 9(11): 1077.     CrossRef
  • Implication of VelB in the development, pathogenicity, and secondary metabolism of Penicillium expansum
    Nadia Tahtah, Chrystian Zetina-Serrano, Ophélie Rocher, Claire Naylies, Yannick Lippi, André El Khoury, Ali Atoui, Emilien L. Jamin, Isabelle P. Oswald, Sophie Lorber, Olivier Puel
    Postharvest Biology and Technology.2023; 195: 112121.     CrossRef
  • Histone 2-Hydroxyisobutyryltransferase Encoded by Afngg1 Is Involved in Pathogenicity and Aflatoxin Biosynthesis in Aspergillus flavus
    Jing Wang, Liuke Liang, Shan Wei, Shuaibing Zhang, Yuansen Hu, Yangyong Lv
    Toxins.2022; 15(1): 7.     CrossRef
  • Roles of AaVeA on Mycotoxin Production via Light in Alternaria alternata
    Liuqing Wang, Meng Wang, Jian Jiao, Hongmei Liu
    Frontiers in Microbiology.2022;[Epub]     CrossRef
  • Regulation of Conidiogenesis in Aspergillus flavus
    He-Jin Cho, Sung-Hun Son, Wanping Chen, Ye-Eun Son, Inhyung Lee, Jae-Hyuk Yu, Hee-Soo Park
    Cells.2022; 11(18): 2796.     CrossRef
  • The Zinc Finger Transcription Factor BbCmr1 Regulates Conidium Maturation in Beauveria bassiana
    Jin-Feng Chen, Jun-Jie Tan, Jun-Yao Wang, A-Jing Mao, Xue-Ping Xu, Yan Zhang, Xue-li Zheng, Yu Liu, Dan jin, Xian-Bi Li, Yan-Hua Fan, Christina A. Cuomo
    Microbiology Spectrum.2022;[Epub]     CrossRef
  • Upstream Regulation of Development and Secondary Metabolism in Aspergillus Species
    Heungyun Moon, Kap-Hoon Han, Jae-Hyuk Yu
    Cells.2022; 12(1): 2.     CrossRef
  • Recent advances in metabolic regulation and bioengineering of gibberellic acid biosynthesis in Fusarium fujikuroi
    Hao-Nan Wang, Xia Ke, Jun-Ping Zhou, Zhi-Qiang Liu, Yu-Guo Zheng
    World Journal of Microbiology and Biotechnology.2022;[Epub]     CrossRef
  • Inhibition ofAspergillus flavus growth and aflatoxin B1 production by natamycin
    P. Chang, B. Tai, M. Zheng, Q. Yang, F. Xing
    World Mycotoxin Journal.2022; 15(3): 269.     CrossRef
  • Regulation of kojic acid production in Aspergillus oryzae
    Motoaki Sano
    JSM Mycotoxins.2022; 72(1): 39.     CrossRef
  • The putative sensor histidine kinase VadJ coordinates development and sterigmatocystin production in Aspergillus nidulans
    Yanxia Zhao, Mi-Kyung Lee, Jieyin Lim, Heungyun Moon, Hee-Soo Park, Weifa Zheng, Jae-Hyuk Yu
    Journal of Microbiology.2021; 59(8): 746.     CrossRef
  • Fungal G-Protein-Coupled Receptors: A Promising Mediator of the Impact of Extracellular Signals on Biosynthesis of Ochratoxin A
    Jing Gao, Xinge Xu, Kunlun Huang, Zhihong Liang
    Frontiers in Microbiology.2021;[Epub]     CrossRef
  • Transcriptomic, Protein-DNA Interaction, and Metabolomic Studies of VosA, VelB, and WetA in Aspergillus nidulans Asexual Spores
    Ming-Yueh Wu, Matthew E. Mead, Mi-Kyung Lee, George F. Neuhaus, Donovon A. Adpressa, Julia I. Martien, Ye-Eun Son, Heungyun Moon, Daniel Amador-Noguez, Kap-Hoon Han, Antonis Rokas, Sandra Loesgen, Jae-Hyuk Yu, Hee-Soo Park, Xiaorong Lin
    mBio.2021;[Epub]     CrossRef
  • Molecular Mechanisms of Conidial Germination in Aspergillus spp
    Tim J. H. Baltussen, Jan Zoll, Paul E. Verweij, Willem J. G. Melchers
    Microbiology and Molecular Biology Reviews.2020;[Epub]     CrossRef
  • The role of the VosA-repressed dnjA gene in development and metabolism in Aspergillus species
    Ye-Eun Son, He-Jin Cho, Wanping Chen, Sung-Hun Son, Mi-Kyung Lee, Jae-Hyuk Yu, Hee-Soo Park
    Current Genetics.2020; 66(3): 621.     CrossRef
  • The velvet Regulator VosA Governs Survival and Secondary Metabolism of Sexual Spores in Aspergillus nidulans
    Min-Ju Kim, Mi-Kyung Lee, Huy Quang Pham, Myeong Ju Gu, Bohan Zhu, Sung-Hun Son, Dongyup Hahn, Jae-Ho Shin, Jae-Hyuk Yu, Hee-Soo Park, Kap-Hoon Han
    Genes.2020; 11(1): 103.     CrossRef
  • Characterizing the role of Zn cluster family transcription factor ZcfA in governing development in two Aspergillus species
    Ye-Eun Son, He-Jin Cho, Mi-Kyung Lee, Hee-Soo Park, Kap-Hoon Han
    PLOS ONE.2020; 15(2): e0228643.     CrossRef
  • Function of crzA in Fungal Development and Aflatoxin Production in Aspergillus flavus
    Su-Yeon Lim, Ye-Eun Son, Dong-Hyun Lee, Tae-Jin Eom, Min-Ju Kim, Hee-Soo Park
    Toxins.2019; 11(10): 567.     CrossRef
  • Conserved Roles of MonA in Fungal Growth and Development inAspergillusSpecies
    Ye-Eun Son, Hee-Soo Park
    Mycobiology.2019; 47(4): 457.     CrossRef
  • The Velvet Proteins VosA and VelB Play Different Roles in Conidiation, Trap Formation, and Pathogenicity in the Nematode-Trapping Fungus Arthrobotrys oligospora
    Guosheng Zhang, Yaqing Zheng, Yuxin Ma, Le Yang, Meihua Xie, Duanxu Zhou, Xuemei Niu, Ke-Qin Zhang, Jinkui Yang
    Frontiers in Microbiology.2019;[Epub]     CrossRef

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