Growing evidence suggests that the gut microbiome is an important
contributor to metabolic diseases. Alterations in microbial
communities are associated with changes in lipid metabolism,
glucose homeostasis, intestinal barrier functions,
and chronic inflammation, all of which can lead to metabolic
disorders. Therefore, the gut microbiome may represent a
novel therapeutic target for obesity, type 2 diabetes, and nonalcoholic
fatty liver disease. This review discusses how gut microbes
and their products affect metabolic diseases and outlines
potential treatment approaches via manipulation of the
gut microbiome. Increasing our understanding of the interactions
between the gut microbiome and host metabolism
may help restore the healthy symbiotic relationship between
them.
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Fungal development and secondary metabolism are closely
associated via the activities of the fungal NK-kB-type velvet
regulators that are highly conserved in filamentous fungi.
Here, we investigated the roles of the velvet genes in the aflatoxigenic
fungus Aspergillus flavus. Distinct from other Aspergillus
species, the A. flavus genome contains five velvet genes,
veA, velB, velC, velD, and vosA. The deletion of velD blocks
the production of aflatoxin B1, but does not affect the formation
of sclerotia. Expression analyses revealed that vosA and
velB mRNAs accumulated at high levels during the late phase
of asexual development and in conidia. The absence of vosA
or velB decreased the content of conidial trehalose and the
tolerance of conidia to the thermal and UV stresses. In addition,
double mutant analyses demonstrated that VosA and
VelB play an inter-dependent role in trehalose biosynthesis
and conidial stress tolerance. Together with the findings of
previous studies, the results of the present study suggest that
the velvet regulators play the conserved and vital role in sporogenesis,
conidial trehalose biogenesis, stress tolerance, and
aflatoxin biosynthesis in A. flavus.
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