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- Volume 49(1); February 2011
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Review
- REVIEW] An Inward Proton Transport Using Anabaena Sensory Rhodopsin
- Akira Kawanabe , Yuji Furutani , Kwang-Hwan Jung , Hideki Kandori
- J. Microbiol. 2011;49(1):1-6. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-0547-x
- 319 View
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Abstract
PDF - ATP is synthesized by an enzyme that utilizes proton motive force and thus nature creates various proton pumps. The best understood proton pump is bacteriorhodopsin (BR), an outward-directed light-driven proton pump in Halobacterium salinarum. Many archaeal and eubacterial rhodopsins are now known to show similar proton transport activity. Proton pumps must have a specific mechanism to exclude transport in the reverse direction to maintain a proton gradient, and in the case of BR, a highly hydrophobic cytoplasmic domain may constitute such machinery. Although an inward proton pump has neither been created naturally nor artificially, we recently reported that an inward-directed proton transport can be engineered from a bacterial rhodopsin by a single amino acid replacement. Anabaena sensory rhodopsin (ASR) is a photochromic sensor in freshwater cyanobacteria, possessing little proton transport activity. When we replace Asp217 at the cytoplasmic domain (distance ~15 Å from the retinal chromophore) to Glu, ASR is converted into an inward proton transport, driven by absorption of a single photon. FTIR spectra clearly show an increased proton affinity for Glu217, which presumably controls the unusual directionality opposite to normal proton pumps.
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Citations
Citations to this article as recorded by
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Yuji Furutani, Chii-Shen Yang
Biophysics and Physicobiology.2023; 20(Supplement): n/a. CrossRef - Bioinformatic analysis of the distribution of inorganic carbon transporters and prospective targets for bioengineering to increase Ci uptake by cyanobacteria
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PLoS ONE.2014; 9(3): e91323. CrossRef - A role of Anabaena sensory rhodopsin transducer (ASRT) in photosensory transduction
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Molecular Microbiology.2014; 93(3): 403. CrossRef - The role of protein-bound water molecules in microbial rhodopsins
Klaus Gerwert, Erik Freier, Steffen Wolf
Biochimica et Biophysica Acta (BBA) - Bioenergetics.2014; 1837(5): 606. CrossRef - Microcompartments and Protein Machines in Prokaryotes
Milton H. Saier Jr.
Microbial Physiology.2013; 23(4-5): 243. CrossRef - Quantum chemical modeling of rhodopsin mutants displaying switchable colors
Federico Melaccio, Nicolas Ferré, Massimo Olivucci
Physical Chemistry Chemical Physics.2012; 14(36): 12485. CrossRef - Crystal Structure of the Eukaryotic Light-Driven Proton-Pumping Rhodopsin, Acetabularia Rhodopsin II, from Marine Alga
Takashi Wada, Kazumi Shimono, Takashi Kikukawa, Masakatsu Hato, Naoko Shinya, So Young Kim, Tomomi Kimura-Someya, Mikako Shirouzu, Jun Tamogami, Seiji Miyauchi, Kwang-Hwan Jung, Naoki Kamo, Shigeyuki Yokoyama
Journal of Molecular Biology.2011; 411(5): 986. CrossRef
- Ion-transporting mechanism in microbial rhodopsins: Mini-review relating to the session 5 at the 19th International Conference on Retinal Proteins
Research Support, Non-U.S. Gov'ts
- Screening and Identification of a Novel Esterase EstPE from a Metagenomic DNA Library
- So-Youn Park , Hyun-Jae Shin , Geun-Joong Kim
- J. Microbiol. 2011;49(1):7-14. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-0201-7
- 241 View
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- 7 Crossref
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Abstract
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- Esterases represent a large family of hydrolases with broad substrate specificity and functional sequence space. Although many attempts to screen new esterases have been conducted, there have been few reports conducted to discriminate unique enzymes from typical ones based on novel structure and function. In this study, we discovered an esterase and a novel family through a successive assay of whole cells and crude lysates (oxidative open condition). The screened putative esterases from the metagenomic DNA of salted shrimp consisted of 753 bp encoding 27 kDa of polypeptide, namely PE esterase. Sequence analyses revealed that an identical gene was reported from whole genome sequencing of Stenotrophomonas maltophilia K279a. However, its biochemical and phylogenetic characteristics have not yet been evaluated. PE esterase was overexpressed only by the MBP fusion state in E. coli and was easily purified using an affinity column. This enzyme showed a typical spectrum of substrate specificity and possessed the consensus motifs, Ser-Asp-His and GXSXG, which are essential for most esterase/lipase superfamilies. Interestingly, the entire organization of the ORF and consensus sequence around the active site were distinct from the related enzymes, and its structure could be affected by a reducing agent, DTT.
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Citations
Citations to this article as recorded by- Isolation, identification, and biochemical characterization of a novel bifunctional phosphomannomutase/phosphoglucomutase from the metagenome of the brown alga Laminaria digitata
Stephen A. Jackson, Maohang Duan, Pengyan Zhang, Maureen W. Ihua, Dagmar B. Stengel, Delin Duan, Alan D. W. Dobson
Frontiers in Microbiology.2022;[Epub] CrossRef - Recombinant expression and characterization of two glycoside hydrolases from extreme alklinphilic bacterium Cellulomonas bogoriensis 69B4T
Fan Li, Jiaying Dong, Xue Lv, Yanqiu Wen, Shan Chen
AMB Express.2020;[Epub] CrossRef - Recent Advances in Function-Based Metagenomic Screening
Tanyaradzwa Rodgers Ngara, Houjin Zhang
Genomics, Proteomics & Bioinformatics.2018; 16(6): 405. CrossRef - Molecular cloning and characterization of a thermostable esterase/lipase produced by a novel Anoxybacillus flavithermus strain
Laura Chiş, Monica Hriscu, Adriana Bica, Monica Toşa, Gergely Nagy, Gergely Róna, Beata G. Vértessy, Florin Dan Irimie
The Journal of General and Applied Microbiology.2013; 59(2): 119. CrossRef - Biochemical Diversity of Carboxyl Esterases and Lipases from Lake Arreo (Spain): a Metagenomic Approach
M�nica Mart�nez-Mart�nez, Mar�a Alcaide, Anatoli Tchigvintsev, Oleg Reva, Julio Polaina, Rafael Bargiela, Mar�a-Eugenia Guazzaroni, �lvaro Chicote, Albert Canet, Francisco Valero, Eugenio Rico Eguizabal, Mar�a del Carmen Guerrero, Alexander F. Yakunin, Ma
Applied and Environmental Microbiology.2013; 79(12): 3553. CrossRef - Isolation of a thioesterase gene from the metagenome of a mountain peak, Apharwat, in the northwestern Himalayas
Avneet Kour Sudan, Jyoti Vakhlu
3 Biotech.2013; 3(1): 19. CrossRef - Discovery and Protein Engineering of Biocatalysts for Organic Synthesis
Geoffrey A. Behrens, Anke Hummel, Santosh K. Padhi, Sebastian Schätzle, Uwe T. Bornscheuer
Advanced Synthesis & Catalysis.2011; 353(13): 2191. CrossRef
- Isolation, identification, and biochemical characterization of a novel bifunctional phosphomannomutase/phosphoglucomutase from the metagenome of the brown alga Laminaria digitata
- Distinctive Endophytic Fungal Assemblage in Stems of Wild Rice (Oryza granulata) in China with Special Reference to Two Species of Muscodor (Xylariaceae)
- Zhi-lin Yuan , Zhen-zhu Su , Li-juan Mao , Yang-qing Peng , Guan-mei Yang , Fu-cheng Lin , Chu-long Zhang
- J. Microbiol. 2011;49(1):15-23. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-0213-3
- 266 View
- 0 Download
- 26 Crossref
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Abstract
PDF
- Ecological niches in the rhizosphere and phyllosphere of grasses capable of sustaining endophytes have been extensively studied. In contrast, little information regarding the identity and functions of endophytic fungi in stems is available. In this study, we investigated the taxonomic affinities, diversity, and host specificities of culturable endophytes in stems of wild rice (Oryza granulata) in China. Seventy-four isolates were recovered. Low recovery rate (11.7%) indicated that there were relatively few sites for fungal infection. Identification using morphology, morphospecies sorting, and molecular techniques resulted in classification into 50 taxa, 36 of which were recovered only once. Nucleotide sequence similarity analysis indicated that 30% of the total taxa recovered were highly divergent from known species and thus may represent lineages new to science. Most of the taxa were classified as members of the classes Sordariomycetes or Dothideomycetes (mainly in Pleosporales). The presence of Arthrinium and Magnaporthaceae species, most often associated with poaceous plants, suggested a degree of host specificity. A polyphasic approach was employed to identify two Muscodor taxa based on (i) ITS and RPB2 phylogenies, (ii) volatile compounds produced, and (iii) an in vitro bioassay of antifungal activity. This to our knowledge is only the second report regarding the isolation of Muscodor spp. in China. Therefore, we hypothesize that wild plants represent a huge reservoir of unknown fungi. The prevalence, novelty, and species-specificity of unique isolates necessitate a reevaluation of their contribution to ecosystem function and fungal biodiversity.
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Citations
Citations to this article as recorded by- Growth-Promoting Effects of Dark Septate Endophytes Fungus Acrocalymma on Tomato (Solanum lycopersicum)
Xiaoxiao Feng, Ying Jin, Zhupeiqi Zhong, Yongli Zheng, Huiming Wu
Journal of Fungi.2025; 11(7): 510. CrossRef - Prospects of fungal endophytes for stress mitigation in rice (Oryza sativa L.)
Boby Vattekkattu Unnikrishnan, Mahesh Mohan
Oryza-An International Journal on Rice.2022; 59(3): 309. CrossRef - Pest categorisation of Colletotrichum aenigma, C. alienum, C. perseae, C. siamense and C. theobromicola
Claude Bragard, Paula Baptista, Elisavet Chatzivassiliou, Francesco Di Serio, Paolo Gonthier, Josep Anton Jaques Miret, Annemarie Fejer Justesen, Alan MacLeod, Christer Sven Magnusson, Panagiotis Milonas, Juan A Navas‐Cortes, Stephen Parnell, Roel Potting
EFSA Journal.2022;[Epub] CrossRef - Phytotoxic compounds from endophytic fungi
Martha Lydia Macías-Rubalcava, Monserrat Yesenia Garrido-Santos
Applied Microbiology and Biotechnology.2022; 106(3): 931. CrossRef - Cross-pathogenicity of Colletotrichum isolates on tropical fruit species in Brazil
André Freire Cruz, Geleta Dugassa Barka, Luiz Eduardo Bassay Blum
Archives of Phytopathology and Plant Protection.2021; 54(5-6): 295. CrossRef - Endophytic microbes from Nigerian ethnomedicinal plants: a potential source for bioactive secondary metabolites—a review
Chijioke E. Ezeobiora, Nwamaka H. Igbokwe, Dina H. Amin, Udoma E. Mendie
Bulletin of the National Research Centre.2021;[Epub] CrossRef - Life on the Rocks: First Insights Into the Microbiota of the Threatened Aquatic Rheophyte Hanseniella heterophylla
Witoon Purahong, Shakhawat Hossen, Ali Nawaz, Dolaya Sadubsarn, Benjawan Tanunchai, Sven Dommert, Matthias Noll, La-aw Ampornpan, Petcharat Werukamkul, Tesfaye Wubet
Frontiers in Plant Science.2021;[Epub] CrossRef - Elucidation of the life cycle of the endophytic genus Muscodor and its transfer to Induratia in Induratiaceae fam. nov., based on a polyphasic taxonomic approach
Milan C. Samarakoon, Benjarong Thongbai, Kevin D. Hyde, Mark Brönstrup, Ulrike Beutling, Christopher Lambert, Andrew N. Miller, Jian-Kui (Jack) Liu, Itthayakorn Promputtha, Marc Stadler
Fungal Diversity.2020; 101(1): 177. CrossRef - Responses of the species complex Fallopia × bohemica to single-metal contaminations to Cd, Cr or Zn: growth traits, metal accumulation and secondary metabolism
Louise Barberis, Wilfried Chevalier, Marie-Laure Toussaint, Philippe Binet, Florence Piola, Serge Michalet
Environmental Monitoring and Assessment.2020;[Epub] CrossRef - Plant host and drought shape the root associated fungal microbiota in rice
Beatriz Andreo-Jimenez, Philippe Vandenkoornhuyse, Amandine Lê Van, Arvid Heutinck, Marie Duhamel, Niteen Kadam, Krishna Jagadish, Carolien Ruyter-Spira, Harro Bouwmeester
PeerJ.2019; 7: e7463. CrossRef - Plant-mycorrhizal fungi interaction and response to inoculation with different growth-promoting fungi
Carlos Vergara, Karla Emanuelle Campos Araujo, Sônia Regina de Souza, Nivaldo Schultz, Orivaldo José Saggin Júnior, Marcus Vinícius Loss Sperandio, Jerri Édson Zilli
Pesquisa Agropecuária Brasileira.2019;[Epub] CrossRef - Identification and characterization of new Muscodor endophytes from gramineous plants in Xishuangbanna, China
Li‐Juan Mao, Jia‐Jie Chen, Chen‐Yang Xia, Xiao‐Xiao Feng, De‐Dong Kong, Zhen‐Yu Qi, Feng Liu, Dian Chen, Fu‐Cheng Lin, Chu‐Long Zhang
MicrobiologyOpen.2019;[Epub] CrossRef - Brief Review on Fungal Endophytes
Rohit Shankar Mane, Padmaa Milaap Paarakh, Ankala Basappa Vedamurthy
International Journal of Secondary Metabolite.2018; 5(4): 288. CrossRef - Contribution of dark septate fungi to the nutrient uptake and growth of rice plants
Carlos Vergara, Karla Emanuelle Campos Araujo, Luiziene Soares Alves, Sônia Regina de Souza, Leandro Azevedo Santos, Claudete Santa-Catarina, Krisle da Silva, Gilmara Maria Duarte Pereira, Gustavo Ribeiro Xavier, Jerri Édson Zilli
Brazilian Journal of Microbiology.2018; 49(1): 67. CrossRef - Endophytic fungal community of Dysphania ambrosioides from two heavy metal‐contaminated sites: evaluated by culture‐dependent and culture‐independent approaches
Shobhika Parmar, Qiaohong Li, Ying Wu, Xinya Li, Jinping Yan, Vijay K. Sharma, Yunlin Wei, Haiyan Li
Microbial Biotechnology.2018; 11(6): 1170. CrossRef - Secondary structure prediction of ITS rRNA region and molecular phylogeny: an integrated approach for the precise speciation of Muscodor species
Neha Kapoor, Lokesh Gambhir, Sanjai Saxena
Annals of Microbiology.2018; 68(11): 763. CrossRef - Endophytic fungi harbored in the root of Sophora tonkinensis Gapnep: Diversity and biocontrol potential against phytopathogens
Yu Qun Yao, Fang Lan, Yun Ming Qiao, Ji Guang Wei, Rong Shao Huang, Liang Bo Li
MicrobiologyOpen.2017;[Epub] CrossRef - Dark Septate Endophytic Fungi Help Tomato to Acquire Nutrients from Ground Plant Material
Carlos Vergara, Karla E. C. Araujo, Segundo Urquiaga, Nivaldo Schultz, Fabiano de Carvalho Balieiro, Peter S. Medeiros, Leandro A. Santos, Gustavo R. Xavier, Jerri E. Zilli
Frontiers in Microbiology.2017;[Epub] CrossRef - Antifungal, anti-oomycete and phytotoxic effects of volatile organic compounds from the endophytic fungusXylariasp. strain PB3f3 isolated fromHaematoxylon brasiletto
B.L. Sánchez-Ortiz, R.E. Sánchez-Fernández, G. Duarte, P. Lappe-Oliveras, M.L. Macías-Rubalcava
Journal of Applied Microbiology.2016; 120(5): 1313. CrossRef - Phylogenetic diversity of culturable endophytic fungi in Dongxiang wild rice (Oryza rufipogon Griff), detection of polyketide synthase gene and their antagonistic activity analysis
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Fungal Biology.2015; 119(11): 1032. CrossRef - Identification of Acremonium isolates from grapevines and evaluation of their antagonism towards Plasmopara viticola
Sandra Lo Piccolo, Antonio Alfonzo, Selene Giambra, Gaetano Conigliaro, Luis V. Lopez-Llorca, Santella Burruano
Annals of Microbiology.2015; 65(4): 2393. CrossRef - Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta
Rosario Nicoletti, Antonio Fiorentino
Agriculture.2015; 5(4): 918. CrossRef - Endophytic Diaporthe from Southeast China are genetically diverse based on multi-locus phylogeny analyses
Jiaying Wang, Xihui Xu, Lijuan Mao, Jiaping Lao, Fucheng Lin, Zhilin Yuan, Chulong Zhang
World Journal of Microbiology and Biotechnology.2014; 30(1): 237. CrossRef - The Colletotrichum boninense species complex
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Studies in Mycology.2012; 73: 1. CrossRef - Current perspectives on the volatile-producing fungal endophytes
Yuan Zhi-Lin, Chen Yi-Cun, Xu Bai-Ge, Zhang Chu-Long
Critical Reviews in Biotechnology.2012; 32(4): 363. CrossRef - Colletotrichum – current status and future directions
P.F. Cannon, U. Damm, P.R. Johnston, B.S. Weir
Studies in Mycology.2012; 73: 181. CrossRef
- Growth-Promoting Effects of Dark Septate Endophytes Fungus Acrocalymma on Tomato (Solanum lycopersicum)
- Halomonas alkalitolerans sp. nov., a Novel Moderately Halophilic Bacterium Isolated from Soda Meadow Saline Soil in Daqing, China
- Shuang Wang , Qian Yang , Zhi-Hua Liu , Lei Sun , Dan Wei , Jun-Zheng Zhang , Jin-Zhu Song , Yun Wang , Jia Song , Jin-Xia Fan , Xian-Xin Meng , Wei Zhang
- J. Microbiol. 2011;49(1):24-28. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-0197-z
- 260 View
- 0 Download
- 5 Crossref
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Abstract
PDF
- A moderately halophilic bacterial strain 15-13T, which was isolated from soda meadow saline soil in Daqing City, Heilongjiang Province, China, was subjected to a polyphasic taxonomic study. The cells of strain 15-13T were found to be Gram-negative, rod-shaped, and motile. The required growth conditions for strain 15-13T were: 1-23% NaCl (optimum, 7%), 10-50°C (optimum, 35°C), and pH 7.0-11.0 (optimum, pH 9.5). The predominant cellular fatty acids were C18:1 ω7c (60.48%) and C16:0 (13.96%). The DNA G+C content was 67.6 mol%. Phylogenetic analysis based on 16S rRNA gene sequence comparisons indicated that strain 15-13T clustered within a branch comprising species of the genus Halomonas. The closest phylogenetic neighbor of strain 15-13T was Halomonas pantelleriensis DSM 9661T (98.9% 16S rRNA gene sequence similarity). The level of DNA-DNA relatedness between the novel isolated strain and H. pantelleriensis DSM 9661T was 33.8%. On the basis of the phenotypic and phylogenetic data, strain 15-13T represents a novel species of the genus Halomonas, for which the name Halomonas alkalitolerans sp. nov. is proposed. The type strain for this novel species is 15-13T (=CGMCC 1.9129T =NBRC 106539T).
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Citations
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- Developments in extremophilic bacterial genomics: A post next generation sequencing era
- Acinetobacter oleivorans sp. nov. Is Capable of Adhering to and Growing on Diesel-Oil
- Yoon-Suk Kang , Jaejoon Jung , Che Ok Jeon , Woojun Park
- J. Microbiol. 2011;49(1):29-34. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-0315-y
- 319 View
- 1 Download
- 55 Crossref
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Abstract
PDF
- A diesel-oil and n-hexadecane-degrading novel bacterial strain, designated DR1T, was isolated from a rice paddy in Deok-So, South Korea. The strain DR1T cells were Gram-negative, aerobic coccobacilli, and grew at 20-37°C with the optimal temperature of 30°C, and an optimal pH of 6-8. Interestingly, strain DR1T was highly motile (swimming and swarming motility) using its fimbriae, and generated N-acyl homoserine lactones as quorum-sensing signals. The predominant respiratory quinone as identified as ubiquinone-9 (Q-9) and DNA G+C content was 41.4 mol%. Comparative 16S rRNA gene sequence-based phylogenetic analysis placed the strain in a clade with the species A. calcoaceticus, A. haemolyticus, A. baumannii, A. baylyi, and A. beijerinckii, with which it evidenced sequence similarities of 98.2%, 97.4%, 97.2%, 97.1%, and 97.0%, respectively. DNA-DNA hybridization values between strain DR1T and other Acinetobacter spp. were all less than 20%. The physiological and taxonomic characteristics with the DNA-DNA hybridization data supported the identification of strain DR1T in the genus Acinetobacter as a novel species, for which the name Acinetobacter oleivorans sp. nov. is proposed. The type strain is DR1T (=KCTC 23045T =JCM 16667T).
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- Young-Gun Zo
- J. Microbiol. 2011;49(1):35-45. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-1024-2
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Abstract
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- Enterobacterial repetitive intergenic consensus (ERIC) sequence is a transcription-modulating, nonautonomous, miniature inverted-repeat transposable element. Its origin and the mechanism of highly varying incidences, limited to Enterobacteriaceae and Vibrionaceae, have not been identified. In this study, distribution and divergence of ERICs along bacterial taxonomic units were analyzed. ERICs were found among five families of gammaproteobacteria, with the copy numbers varying with exponential increments. The variability was explained by genus (45%) and species (36%) affiliations, indicating that copy numbers are specific to subfamily taxa. ERICs were interspersed in genomes with considerable divergences. Locations of ERICs in a genome appeared to be strongly conserved in a strain, moderately in a species or a genus, and weakly in a family. ERICs in different species of a genus were from the identical population of sequences while ERICs in different genera of a family were nearly identical. However, ERICs in different families formed distinct monophylectic groups, implying vertical transmission of diverging population of sequences. In spite of large difference in copy numbers, overall intra-genome evolutionary distances among ERICs were similar among different species, except for a few genomes. The exceptions substantiated hypotheses of genetic drifts and horizontal gene transfers of mobility capacity. Therefore, the confined, variable distribution of ERIC could be explained as a two-step evolution: introduction and proliferation of ERIC in one of the progenitors of gammaproteobacteria, followed by vertical transmission under negative selection. Deterioration of sequences and reduction in copy number were concluded to be the predominant patterns in the evolution of ERIC loci.
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Citations to this article as recorded by- Functional Roles and Genomic Impact of Miniature Inverted-Repeat Transposable Elements (MITEs) in Prokaryotes
Michael F. Minnick
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- Occurrence and Antimicrobial Drug Susceptibility Patterns of Commensal and Diarrheagenic Escherichia coli in Fecal Microbiota from Children with and without Acute Diarrhea
- Patrícia G. Garcia , Vânia L. Silva , Cláudio G. Diniz
- J. Microbiol. 2011;49(1):46-52. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-0172-8
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Abstract
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- Acute diarrhea is a public health problem and an important cause of morbidity and mortality, especially in developing countries. The etiology is varied, and the diarrheagenic Escherichia coli pathotypes are among the most important. Our objectives were to determine the occurrence of commensal and diarrheagenic E. coli strains in fecal samples from children under five years old and their drug susceptibility patterns. E. coli were isolated from 141 fresh fecal samples; 84 were obtained from clinically injured donors with acute diarrhea (AD) and 57 from clinically healthy donors without diarrhea (WD). Presumptive phenotypic species identification was carried out and confirmed by amplification of specific 16S ribosomal RNA encoding DNA. Multiplex PCR was performed to characterize the diarrheagenic E. coli strains. Drug susceptibility patterns were determined by the disc-diffusion method. In total, 220 strains were recovered from the fecal specimens (61.8% from AD and 38.2% from WD). Diarrheagenic E. coli was identified at a rate of 36.8% (n=50) in diarrheic feces and 29.8% (n=25) in non-diarrheic feces. Enteroaggregative E. coli was the most frequently identified pathotype in the AD group (16.2%) and the only pathotype identified in the WD group (30.9%). Enteropathogenic E. coli was the second most isolated pathotype (10.3%), followed by Shiga toxin-producing E. coli (7.4%) and enterotoxigenic E. coli (2.9%). No enteroinvasive E. coli strains were recovered. The isolates showed high resistance rates against ampicillin, tetracycline, and sulfamethoxazole-trimethoprim. The most effective drugs were ceftazidime, ceftriaxone, imipenem and piperacillin-tazobactam, for which no resistance was observed. Differentiation between the diarrheagenic E. coli pathotypes is of great importance since they are involved in acute diarrheal diseases and may require specific antimicrobial chemotherapy. The high antimicrobial resistance observed in our study raises a broad discussion on the indiscriminate or improper use of antimicrobials, besides the risks of self-medication.
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- Deoxycytidine Production by Metabolically Engineered Corynebacterium ammoniagenes
- Yun-Bom Lee , Hong Baek , Sang-Kyum Kim , Hyung-Hwan Hyun
- J. Microbiol. 2011;49(1):53-57. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-0195-1
- 245 View
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Abstract
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- Corynebacterium ammoniagenes N424 was metabolically modified to isolate overproducers of deoxycytidine. Inosine auxotrophy (ino-) was initially introduced to prevent the flow of PRPP (phosphoribosyl pyrophosphate) into the purine biosynthetic pathway by random mutagenesis using N-methyl-N'-nitro-N-nitrosoguanidine. Following that, mutants possessing hydroxyurea resistance (HUr) were isolated to increase the activity of ribonucleoside diphosphate reductase, which catalyzes the reduction of ribonucleoside diphosphate to deoxyribonucleoside diphosphate. Then, in order to block the flow of dCTP into the TMP biosynthetic pathway via dUTP, thymine auxotrophy (thy-) was introduced into the mutant IH30 with ino- and HUr. The resulting mutant IM7, possessing the characteristics of ino-, HUr, and thy-, was deficient in dCTP deaminase and produced significantly higher amounts of deoxycytidine (81.3 mg/L) compared to its mother strain IH30 (6.2 mg/L). Deoxycytidine productivity was further enhanced by isolating the mutant IU19, which was resistant to 5-fluorouracil, an inhibitor of carbamoyl phosphate synthase. This enzyme catalyzed the synthesis of carbamoyl phosphate from glutamine, HCO3 -, and ATP. 5-Fluorouracil also inhibited aspartate transcarbamoylase, catalyzeing the condensation of carbamoyl phosphate and aspartate. Finally, 5-fluorocytosine resistance (FCr) was introduced into the mutant strain IU19 to relieve the repression caused by accumulation of pyrimidine nucleosides. The mutant strain IC14-C6 possessing all the five characteristics described above produced 226.3 mg/L of deoxycytidine, which was at least 2,000 fold higher compared to the wild type, and accumulated only a negligible amount of other pyrimidines under shake flask fermentation.
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Journal Article
- Organic Acids Associated with Saccharification of Cellulosic Wastes During Solid-State Fermentation
- Noura El-Ahmady El-Naggar , Mohammed Saad El-Hersh
- J. Microbiol. 2011;49(1):58-65. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-0288-x
- 210 View
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- 13 Crossref
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Abstract
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- Saccharification of five cellulosic wastes, i.e. rice husks, wheat bran, corn cobs, wheat straw and rice straw by three cellulytic fungi, i.e. Aspergillus glaucus MN1, Aspergillus oryzae MN2 and Penicillium purpurogenum MN3, during solid-state fermentation (SSF) was laboratory studied. Rice husks, wheat bran, and corn cobs were selected as inducers of glucose production in the tested fungi. An incubation interval of 10 days was optimal for glucose production. Maximal activities of the cellulases FP-ase, CMC-ase, and β-glucosidase were detected during SSF of rice husks by P. purpurogenum; however, α-amylase activity (7.2 U/g) was comparatively reduced. Meanwhile, the productivities of FP-ase, CMC-ase, and β-glucosidase were high during SSF of rice husks by A. glaucus; however, they decreased during SSF of corn cobs by P. purpurogenum. Addition of rock phosphate (RP) (75 mg P2O5) decreased the pH of SSF media. (NH4)2SO4 was found to be less inducer of cellulytic enzymes, during SSF of rice husks by A. glaucus or A. oryzae; it also induced phytase production and solubilization of RP. The organic acids associated with saccharification of the wastes studied have also been investigated. The highest concentration of levulinic acid was detected (46.15 mg/g) during SSF of corn cobs by P. purpurogenum. Likewise, oxalic acid concentration was 43.20 mg/g during SSF of rice husks by P. purpurogenum.
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Citations
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Camila Langer Marciano, Aline Pereira de Almeida, Fabiane Cruz Bezerra, Giovana Cristina Giannesi, Hamilton Cabral, Maria de Lourdes Teixeira de Moraes Polizeli, Roberto Ruller, Douglas Chodi Masui
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Research Support, Non-U.S. Gov'ts
- Production of Anti-Helicobacter pylori Metabolite by the Lichen-Forming Fungus Nephromopsis pallescens
- Heng Luo , Yoshikazu Yamamoto , Hae-Sook Jeon , Yan Peng Liu , Jae Sung Jung , Young Jin Koh , Jae-Seoun Hur
- J. Microbiol. 2011;49(1):66-70. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-0289-9
- 212 View
- 0 Download
- 13 Crossref
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Abstract
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- The present study was conducted to evaluate the antibacterial activity of lichen-forming fungi (LFF) against Helicobacter pylori, and to optimize the culture conditions of LFF for maximum production of natural antibiotics against H. pylori. To accomplish this, a screening assay was first conducted among 19 species of LFF. The extract of Nephromopsis pallescens (KOLRI-040516) exhibited the strongest anti-H. pylori activity. Bioautograghic TLC and HPLC analysis identified usnic acid as the main antibacterial substance produced by N. pallescens. The growth of N. pallescens and production of antibacterial substances produced by the fungus were then investigated under several culture conditions including the culture media, initial medium pHs, incubation temperatures, and the degree of aeration. The results indicated that culture in MY medium with an initial pH of 6.0, a temperature of 15°C and a low degree of aeration supported the largest usnic acid production of the fungus (16.4 μg usnic acid/g dry biomass). Especially, aeration was found to be an important factor that affect both growth and usnic acid production of N. pallescens.
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Citations
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Rundong Liu, Jaycee Augusto Paguirigan, Jae-Seoun Hur, Wonyong Kim
Mycoscience.2024; 65(1): 19. CrossRef - Faecal microbiota transplantation for eradicating Helicobacter pylori infection: clinical practice and theoretical postulation
Zhi-Ning Ye, Guy D Eslick, Shao-Gang Huang, Xing-Xiang He
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D. C. S. Macedo, F. J. F. Almeida, M. S. O. Wanderley, M. S. Ferraz, N. P. S. Santos, A. M. Q. López, N. S. Santos-Magalhães, M. C. B. Lira-Nogueira
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Zhi‐Hang Tao, Ji‐Xuan Han, Jing‐Yuan Fang
Helicobacter.2020;[Epub] CrossRef - Antimicrobial Activity of Divaricatic Acid Isolated from the Lichen Evernia mesomorpha against Methicillin-Resistant Staphylococcus aureus
Jong Min Oh, Yi Jeong Kim, Hyo-Seung Gang, Jin Han, Hyung-Ho Ha, Hoon Kim
Molecules.2018; 23(12): 3068. CrossRef - Usnic acid and its derivatives for pharmaceutical use: a patent review (2000–2017)
Olga A. Luzina, Nariman F. Salakhutdinov
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Yi Wang, Changan Geng, Xiaolong Yuan, Mei Hua, Fenghua Tian, Changtian Li, Marie-Joelle Virolle
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O. A. Luzina, N. F. Salakhutdinov
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Vasudeo P. Zambare, Lew P. Christopher
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- Effect of Light and Reductones on Differentiation of Pleurotus ostreatus
- Seung-Rock Lee , Woo-Jeong Joo , Yong-Un Baek , Inyoung Kim , Kee-Oh Chay , Seung-Hyun Cho , Seung-Jae Lee , Sa-Ouk Kang
- J. Microbiol. 2011;49(1):71-77. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-0507-5
- 256 View
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- 9 Crossref
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Abstract
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- Vegetative mycelia of Pleurotus ostreatus were differentiated into primordia and subsequently into fruit bodies in synthetic sucrose-asparagine medium when exposed to light at low temperature. During photomorphogenesis, L-ascorbic acid-like substances called reductones were produced. L-Ascorbic acid, D-erythroascorbic acid, 5-O-(α-D-glucopyranosyl)-D-erythroascorbic acid, 5-O-(α-D-xylopyranosyl)-D-erythroascorbic acid, 5-methyl-5-O-(α-D-glucopyranosyl)-D-erythroascorbic acid and 5-methyl-5-O-(α-D-xylopyranosyl)-D-erythroascorbic acid were accumulated initially in the illuminated mycelia before the initiation of fruiting. The content of glycosides of erythroascorbic acid and their methylated compounds increased again in the primordia and the fruit bodies. Exogenous L-ascorbic acid induced the formation of primordia from the mycelia in the dark in a dose-dependent manner. Thus, this suggests that these reductones might play a role in mediating the light stimulus in photomorphogenesis.
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Citations
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Liping Zhu, Yao Su, Shunan Ma, Lizhong Guo, Song Yang, Hao Yu
Journal of Agricultural and Food Chemistry.2024; 72(2): 1361. CrossRef - Heat stress and excessive maturity of fruiting bodies suppress GABA accumulation by modulating GABA metabolism in Pleurotus ostreatus (Jacq. ex Fr.) P. Kumm
Qing Wen, Haoyang Zhao, Yanhong Shao, Jiatao Li, Yanru Hu, Yuancheng Qi, Fengqin Wang, Jinwen Shen
Food Research International.2023; 165: 112549. CrossRef - Effect of Different Light Qualities and Intensities on the Yield and Quality of Facility-Grown Pleurotus eryngii
Zonghan Yue, Wei Zhang, Wenjun Liu, Jia Xu, Wen Liu, Xinyu Zhang
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Karen P. Quintero‐Cabello, Patricia Palafox‐Rivera, Marco A. Lugo‐Flores, Rigoberto Gaitán‐Hernández, Gustavo A. González‐Aguilar, Brenda A. Silva‐Espinoza, Orlando Tortoledo‐Ortiz, J. Fernando Ayala‐Zavala, Juan L. Monribot‐Villanueva, José A. Guerrero‐A
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Yuancheng Qi, Ruixia Zhang, Mengke Zhang, Qing Wen, Jinwen Shen
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Scientia Horticulturae.2014; 167: 100. CrossRef
- Comparative Proteomic Analysis Reveals Candidate Pathways Related to the Effect of Different Light Qualities on the Development of Mycelium and Fruiting Body of Pleurotus ostreatus
Research Support, N.I.H., Extramural
- Phenotypes Associated with Saccharomyces cerevisiae Hug1 Protein, a Putative Negative Regulator of dNTP Levels, Reveal Similarities and Differences with Sequence-Related Dif1
- Eunmi Kim# , Wolfram Siede
- J. Microbiol. 2011;49(1):78-85. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-0200-8
- 193 View
- 0 Download
- 4 Scopus
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Abstract
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- Saccharomyces cerevisiae Hug1 is a small protein of unknown function that is highly inducible following replication stress and DNA damage. Its deletion suppresses the lethality of deletion of checkpoint kinase Mec1. Although DNA damage responses were largely normal in the HUG1 deletion mutant, we found enhanced resistance towards heat in logarithmic phase. In response to simultaneous carbon and replication stress, overall growth delay and less pseudohyphal filament formation were evident. These novel phenotypes are shared with deletion mutants of the negative regulators of ribonucleotide reductase, Dif1 and Sml1. Microarray analysis showed the influence of Hug1 on the expression of a large number of transcripts, including stress-related transcripts. Elevated dNTP levels in hug1Δ cells may result in a stress response reflected by the observed phenotypes and transcript profiles. However, in contrast to a deletion of structurally related Dif1, Rnr2-Rnr4 subcellular localization is not grossly altered in a Hug1 deletion mutant. Thus, although Hug1 appears to be derived from the Rnr2-Rnr4 binding region of Dif1, its mechanism of action must be independent of determining the localization of Rnr2-Rnr4.
Research Support, Non-U.S. Gov'ts
- Characterization, Gene Cloning, and Heterologous Expression of β-Mannanase from a Thermophilic Bacillus subtilis
- Pijug Summpunn , Suttidarak Chaijan , Duangnate Isarangkul , Suthep Wiyakrutta , Vithaya Meevootisom
- J. Microbiol. 2011;49(1):86-93. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-0357-1
- 313 View
- 0 Download
- 30 Crossref
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Abstract
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- Bacillus subtilis BCC41051 producing a thermostable β-mannanase was isolated from soybean meal-enriched soil and was unexpectedly found to be thermophilic in nature. The extracellular β-mannanase (ManA) produced was hydrophilic, as it was not precipitated even with ammonium sulfate at 80% saturation. The estimated molecular weight of ManA was 38.0 kDa by SDS-PAGE with a pI value of 5.3. Optimal pH and temperature for mannan-hydrolyzing activity was 7.0 and 60°C, respectively. The enzyme was stable over a pH range of 5.0-11.5, and at temperatures of up to 60°C for 30 min, with more than 80% of its activity retained. ManA was strongly inhibited by Hg2+ (1 mM), but was sensitive to other divalent ions to a lesser degree. The gene of ManA encoded a protein of 362 amino acid residues, with the first 26 residues identified as a signal peptide. High expression of recombinant ManA was achieved in both Escherichia coli BL21 (DE3) (415.18 U/ml) and B. megaterium UNcat (359 U/ml).
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- Fine Mapping of a Foot-and-Mouth Disease Virus Epitope Recognized by Serotype-Independent Monoclonal Antibody 4B2
- Yongzhong Yu , Haiwei Wang , Lei Zhao , Chunyuan Zhang , Zhigang Jiang , Li Yu
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- DOI: https://doi.org/10.1007/s12275-011-0134-1
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- 26 Crossref
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Abstract
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- VP2 is a structural protein of the foot-and-mouth disease virus (FMDV). In this study, a FMDV serotype-independent monoclonal antibody (MAb), 4B2, was generated. By screening a phage-displayed random 12-peptide library, we found positive phages displaying the consensus motif ETTXLE (X is any amino acid (aa)), which is highly homologous to 6ETTLLE11 at the N-terminus of the VP2 protein. Subsequently, a series of GST-fusion proteins expressing a truncated N-terminus of VP2 were examined by western blot analysis using the MAb 4B2. The results indicated that the motif 6ETTLLE11 of VP2 may be the minimal requirement of the epitope recognized by 4B2. Moreover, a 12-aa peptide 2KKTEETTLLEDR13 was shown to be the minimal unit of the epitope with maximal binding activity to 4B2. Alanine-scanning analysis demonstrated thatThr7, Thr8, and Leu10 are the functional residues of the 4B2 epitope Glu6 and Leu9 are required residues, and Glu11 plays a crucial role in the binding of MAb 4B2. The fine mapping of the epitope indicated that MAb 4B2 has the potential to be used in FMDV diagnosis.
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Citations
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- In Vitro Antiviral Activity of Red Alga, Polysiphonia morrowii Extract and Its Bromophenols Against Fish Pathogenic Infectious Hematopoietic Necrosis Virus and Infectious Pancreatic Necrosis Virus
- Su-Yeun Kim , Seok Ryel Kim# , Myung-Joo Oh , Sung-Ju Jung , So Young Kang
- J. Microbiol. 2011;49(1):102-106. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-1035-z
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Abstract
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- Our previous investigation revealed that 80% methanolic extract of the red alga Polysiphonia morrowii has significant antiviral activities against fish pathogenic viruses, infectious hematopoietic necrosis virus (IHNV) and infectious pancreatic necrosis virus (IPNV). The present study was conducted to identify compounds attributed for its antiviral activities and investigate their antiviral activities against IHNV and IPNV. Activityguided fractionation for 80% methanolic extract of Polysiphonia morrowii using a cell-based assay measuring virus-induced cytopathic effect (CPE) on cells yielded a 90% methanolic fraction, which showed the highest antiviral activity against both viruses among fractions yielded from the extract. From the fraction, two bromophenols were isolated and identified as 3-bromo-4,5-dihydroxybenzyl methyl ether (1) and 3-bromo-4,5-dihydroxybenzaldehyde (2) based on spectroscopic analyses. For both compounds, the concentrations to inhibit 50% of flounder spleen cell (FSP cell) proliferation (CC50) and each viral replication (EC50) were measured. In the pretreatment test, 3-bromo-4,5-dihydroxybenzyl methyl ether (1) and 3-bromo-4,5-dihydroxybenzaldehyde (2) exhibited significant antiviral activities showing selective index values (SI = CC50/EC50) of 20 to 42 against both IHNV and IPNV. In direct virucidal test, 3-bromo-4,5-dihydroxybenzyl methyl ether (1) showed significant antiviral activites against both viruses while 3-bromo-4,5-dihydroxybenzaldehyde (2) was significantly effective against only IHNV. Although antiviral efficacies of both compounds against IHNV and IPNV were lower than those of ribavirin used as a positive control, our findings suggested that the red alga Polysiphonia morrowii and isolated two bromophenols may have potential as a therapeutic agent against fish viral diseases.
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- Inactivation of MuxABC-OpmB Transporter System in Pseudomonas aeruginosa Leads to Increased Ampicillin and Carbenicillin Resistance and Decreased Virulence
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- DOI: https://doi.org/10.1007/s12275-011-0186-2
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Abstract
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- Resistance-Nodulation-Cell Division (RND) pumps play important roles in bacterial resistance to antibiotics. Pseudomonas aeruginosa is an important human pathogen which exhibits high level resistance to antibiotics. There are total of 12 RND pumps present in the P. aeruginosa PAO1 genome. The recently characterized MuxABC-OpmB system has been shown to play a role in resistance to novobiocin, aztreonam, macrolides, and tetracycline in a multiple knockout mutation. In this study, we examined the expression levels of all the 12 RND pump gene clusters and tested the involvement of MuxABC-OpmB in pathogenicity. The results indicated that in addition to the four known constitutively expressed RND pumps, mexAB-oprM, mexGHIopmD, mexVW, and mexXY, relatively high levels of expression were observed with mexJK and muxABCopmB in the conditions tested. Inactivation of muxA in the muxABC-opmB operon resulted in elevated resistance to ampicillin and carbenicillin. The mutant also showed attenuated virulence in both Brassica rapa pekinensis and Drosophila melanogaster infection models. The decreased virulence at least in part was due to decreased twitching motility in the mutant. These results indicate that the RND pump MuxABC-OpmB is associated with ampicillin and carbenicillin susceptibility and also involved in pathogenesis in P. aeruginosa.
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Citations
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- DOI: https://doi.org/10.1007/s12275-011-1037-x
- 220 View
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- 3 Crossref
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Abstract
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- Dendritic cell (DC)-based immunotherapy is a potent therapeutic modality for treating renal cell carcinoma (RCC), but development of antigens specific for tumor-targeting and anti-tumor immunity is of great interest for clinical trials. The present study investigated the ability of DCs pulsed with a combination of carbonic anhydrase IX (CA9) as an RCC-specific biomarker and Acinetobacter baumannii outer membrane protein A (AbOmpA) as an immunoadjuvant to induce anti-tumor immunity against murine renal cell carcinoma (RENCA) in a murine model. Murine bone-marrow-derived DCs pulsed with a combination of RENCA lysates and AbOmpA were tested for their capacity to induce DC maturation and T cell responses in vitro. A combination of RENCA lysates and AbOmpA up-regulated the surface expression of co-stimulatory molecules, CD80 and CD86, and the antigen presenting molecules, major histocompatibility (MHC) class I and class II, in DCs. A combination of RENCA lysates and AbOmpA also induced interleukin-12 (IL-12) production in DCs. Next, the immunostimulatory activity of DCs pulsed with a combination of CA9 and AbOmpA was determined. A combination of CA9 and AbOmpA up-regulated the surface expression of co-stimulatory molecules and antigen presenting molecules in DCs. DCs pulsed with a combination of CA9 and AbOmpA effectively secreted IL-12 but not IL-10. These cells interacted with T cells and formed clusters. DCs pulsed with CA9 and AbOmpA elicited the secretion of interferon-γ and IL-2 in T cells. In conclusion, a combination of CA9 and AbOmpA enhanced the immunostimulatory activity of DCs, which may effectively induce anti-tumor immunity against human RCC.
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Journal Articles
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- 232 View
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Abstract
PDF
- The serine protease gene from a thermophilic fungus Thermoascus aurantiacus var. levisporus, was cloned, sequenced, and expressed in Pichia pastoris and the recombinant protein was characterized. The full-length cDNA of 2,592 bp contains an ORF of 1,482 bp encoding 494 amino acids. Sequence analysis of the deduced amino acid sequence revealed high homology with subtilisin serine proteases. The putative enzyme contained catalytic domain with active sites formed by three residues of Asp183, His215, and Ser384. The molecular mass of the recombinant enzyme was estimated to be 59.1 kDa after overexpression in P. pastoris. The activity of recombinant protein was 115.58 U/mg. The protease exhibited its maximal activity at 50°C and pH 8.0 and kept thermostable at 60°C, and retained 60% activity after 60 min at 70°C. The protease activity was found to be inhibited by PMSF, but not by DTT or EDTA. The enzyme has broad substrate specificity such as gelatin, casein and pure milk, and exhibiting highest activity towards casein.
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Abstract
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- L-Methioninase was purified to electrophoretic homogeneity from cultures of Aspergillus flavipes using anionexchange and gel filtration chromatography by 12.1 fold compared to the crude enzyme preparation. The purified enzyme had a molecular mass of 47 kDa under denaturing conditions and an isoelectric point of 5.8 with no structural glycosyl residues. The enzyme had optimum activity at pH 7.8 and pH stability from 6.8-8.0 at 35°C. The enzyme appeared to be catalytically stable below 40°C. The enzyme activity was strongly inhibited by DL-propargylglycine, hydroxylamine, PMSF, 2-mercaptoethanol, Hg2+, Cu2+, and Fe2+, with slight inhibition by Triton X-100. A. flavipes L-methioninase has a higher catalytic affinity towards L-methionine (Km, 6.5 mM and Kcat, 14.1 S-1) followed by a relative demethiolating activity to L-homocysteine (Km, 12 mM and Kcat, 9.3 S-1). The enzyme has two absorption maxima at 280 and 420 nm, typical of other PLP-enzymes. Apo-L-methioninase has the ability to reconstitute its structural catalytic state completely upon addition of 0.15 mM PLP. L-Methioninase has neither an appreciable effect on liver function, platelet aggregation, nor hemolysis of human blood. The purified L-methioninase from solid cultures of A. flavipes displayed unique biochemical and catalytic properties over the currently applied Pseudomonad enzyme.
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Research Support, Non-U.S. Gov'ts
- Screening and Characterization of a Cellulase Gene from the Gut Microflora of Abalone Using Metagenomic Library
- Duwoon Kim , Se-Na Kim , Keun Sik Baik , Seong Chan Park , Chae Hong Lim , Jong-Oh Kim , Tai-Sun Shin , Myung-Joo Oh , Chi Nam Seong
- J. Microbiol. 2011;49(1):141-145. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-0205-3
- 177 View
- 0 Download
- 11 Crossref
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Abstract
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- A metagenomic fosmid library was constructed using genomic DNA isolated from abalone intestine. Screening of a library of 3,840 clones revealed a 36 kb insert of a cellulase positive clone (pAM11E10). A shotgun clone library was constructed using the positive clone (pAM11E10) and further screening of 3,840 shotgun clones with an approximately 5 kb insert size using a Congo red overlay revealed only one cellulase positive clone (pAM11L9). The pAM11L9 consisted of a 5,293-bp DNA sequence and three open reading frames (ORFs). Among the three ORFs, cellulase activity was only shown in the recombinant protein (CelAM11) coded by ORF3, which showed 100% identity with outer membrane protein A from Vibrio alginolyticus 12G01, but no significant sequence homology to known cellulases. The expressed protein (CelAM11) has a molecular weight of approximately 37 kDa and the highest CMC hydrolysis activity was observed at pH 7.0 and 37°C. The carboxymethyl cellulase activity was determined by zymogram active staining and different degraded product profiles for CelAM11 were obtained when cellotetraose and cellopentaose were used as the substrates, while no substrate hydrolysis was observed on oligosaccharides such as cellobiose and cellotriose.
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Citations
Citations to this article as recorded by- Comparative genomics reveal distinct potential of Tamlana sp. S12 for algal polysaccharide degradation
Hai-Feng Xia, Xiao-Yu Jia, Yan-Xia Zhou, Zong-Jun Du, Da-Shuai Mu, Guan-Jun Chen
Frontiers in Marine Science.2023;[Epub] CrossRef - A primer on metagenomics and next‐generation sequencing in fish gut microbiome research
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Proceedings of the National Academy of Sciences, India Section B: Biological Sciences.2019; 89(3): 1079. CrossRef - Prospects of Metagenomic Cellulases for Converting Lignocellulosic Biomass into Bio-ethanol
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Critical Reviews in Biotechnology.2016; 36(6): 998. CrossRef - Identification and Characterization of Carboxyl Esterases of Gill Chamber-Associated Microbiota in the Deep-Sea Shrimp Rimicaris exoculata by Using Functional Metagenomics
María Alcaide, Anatoli Tchigvintsev, Mónica Martínez-Martínez, Ana Popovic, Oleg N. Reva, Álvaro Lafraya, Rafael Bargiela, Taras Y. Nechitaylo, Ruth Matesanz, Marie-Anne Cambon-Bonavita, Mohamed Jebbar, Michail M. Yakimov, Alexei Savchenko, Olga V. Golysh
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- Antifungal Activity and Mechanism of Fengycin in the Presence and Absence of Commercial Surfactin Against Rhizopus stolonifer
- Yang Tao , Xiao-mei Bie , Feng-xia Lv , Hai-zhen Zhao , Zhao-xin Lu
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- DOI: https://doi.org/10.1007/s12275-011-0171-9
- 186 View
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- 81 Scopus
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Abstract
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- The antifungal activity and mechanism of fengycin in the presence and absence of commercial surfactin against Rhizopus stolonifer were investigated. The MIC (minimal inhibitory concentration) of fengycin without commercial surfactin added was 0.4 mg/ml while the MIC of fengycin with commercial surfactin added was 2.0 mg/ml. Fengycin acted on cell membrane and cellular organs and inhibited DNA synthesis. The antifungal effect of fengycin was reduced after commercial surfactin was added. All these results suggest that the fungal cell membrane may be the primary target of fengycin action and commercial surfactin may reduce the antifungal activity of fengycin.
- Molecular Cloning and Expression Analysis of a Delta 6-Fatty Acid Desaturase Gene from Rhizopus stolonifer Strain YF6 Which Can Accumulate High Levels of Gamma-Linolenic Acid
- Xia Wan , Yinbo Zhang , Ping Wang , Mulan Jiang
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- DOI: https://doi.org/10.1007/s12275-011-0254-7
- 179 View
- 0 Download
- 11 Crossref
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Abstract
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- The delta 6-desaturase gene was cloned from Rhizopus stolonifer, which could accumulate up to 49% of gamma-linolenic acid (GLA, C18:3 Δ6,9,12) to the total fatty acids. The cloned DNA contains a 1,380 bp open reading frame encoding a protein of 460 amino acids, which showed high similarity to those of fungal delta 6-desaturases with three conserved histidine-rich motifs and HPGG motif. Notably, this deduced sequence had a shorter C-terminus. Results demonstrated that the cDNA sequence exhibited delta 6-desaturase activity by accumulation of about 22.4% of GLA to the total fatty acids in the recombinant Pichia pastoris strain GS115.
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Mojgan Latifi, Foroozan Jalali Bidgoli, Helia Hajihassani, Danial Hassani, Pär K. Ingvarsson, Naser Farrokhi
Frontiers in Bioengineering and Biotechnology.2025;[Epub] CrossRef - Metabolic engineering of omega-3 long chain polyunsaturated fatty acids in plants using different ∆6- and ∆5-desaturases co-expressed with LPCAT from the marine diatom Phaeodactylum tricornutum
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Maryam Sadat Mirbagheri Firoozabad, Hamidreza Akhbariyoon
Archives of Microbiology.2022;[Epub] CrossRef - Functional characterization of a Δ6 fatty acid desaturase gene and its 5′-upstream region cloned from the arachidonic acidrich microalga Myrmecia incisa Reisigl (Chlorophyta)
Li Zhang, Haisheng Cao, Pu Ning, Zhigang Zhou
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- Characterization of Sgr3394 Produced only by the A-Factor-Producing Streptomyces griseus IFO 13350, not by the A-Factor Deficient Mutant HH1
- Won-Jae Chi , Xue-Mei Jin , Sung-Cheol Jung , Eun A Oh , Soon-Kwang Hong
- J. Microbiol. 2011;49(1):155-160. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-0330-z
- 196 View
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- 2 Crossref
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Abstract
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- Protein D (9.7 kDa) is an extracellular protein detected in the culture broth of A-factor-producing Streptomyces griseus IFO 13350, but not of the A-factor-deficient mutant strain S. griseus HH1. Comparison of the N-terminal amino acid sequence with the genomic sequencing data of S. griseus IFO 13350 identified protein D as Sgr3394, which encodes a putative secretory protein with unknown function. The premature Sgr3394 consisted of 128 amino acids (13.5 kDa), showed 87.5% identity with SACT1DRAFT-0503, from Streptomyces sp. ACT-1, and 68.8% identity with SrosN15-18634, from S. roseosporus NRRL15998, and was confirmed to be matured for secretion by a peptide cleavage between the Ala-38 and Ala-39 bond. RT-PCR anaylsis of Sgr3394 clearly showed that it can be transcribed in the wild-type strain, but not in the A-factor-deficient strain. However, a gel-mobility shift assay of the promoter region of sgr3394 with A-factor-dependent transcriptional regulator (AdpA) showed that AdpA could not specifically recognize the putative AdpA-binding site (5′-TCCCCCGAAT-3′). All of these data strongly suggest that the expression of sgr3394 is not directly induced by AdpA but is regulated indirectly by an A-factor dependent protein. Introduction of sgr3394 on a high-copy-numbered plasmid (pWHM3-sgr3394) into S. lividans TK21 induced massive production of actinorhodin (blue pigment) and undecylprodigiosin (red pigment). Compared to the control, production of each pigment increased by 6.1 and 2.6 times, respectively, on R2YE agar, and 3.1 and 1.4 times, respectively, in R2YE broth; there was little influence on morphogenesis. In S. coelicolor A3(2)/pWHM3-sgr3394, actinorhodin and undecylprodigiosin productions were enhanced to 1.8 and 1.1 times those observed in the control, respectively, suggesting that overexpression of sgr3394 can stimulate secondary metabolism, especially actinorhodin biosynthesis, in S. lividans and S. coelicolor.
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Citations to this article as recorded by- Genes for biosynthesis of butenolide-like signalling molecules in Streptomyces ghanaensis, their role in moenomycin production
H. Mutenko, R. Makitrinskyy, O. Tsypik, S. Walker, B. Ostash, V. Fedorenko
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- Genes for biosynthesis of butenolide-like signalling molecules in Streptomyces ghanaensis, their role in moenomycin production
- Antimicrobial Effect of Korean Propolis Against the Mutans Streptococci Isolated from Korean
- Min Jung Kim , Chun Sung Kim , Byung-Hoon Kim , Sang-Bok Ro , Yun Kyong Lim , Soon-Nang Park , Engene Cho , Jang-Hyuk Ko , Soon-Sung Kwon , Yeong-Mu Ko , Joong-Ki Kook
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- DOI: https://doi.org/10.1007/s12275-011-1002-8
- 226 View
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- 22 Crossref
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Abstract
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- The aim of this study was to determine the optimal concentration of Korean propolis against clinical isolates of mutans streptococci (MS) from Koreans. The antimicrobial activity was evaluated using the minimum inhibitory concentration (MIC) and time-kill curves against mutans streptococci. The MIC90 values of propolis for MS were 35 μg/ml. Propolis had a bacteriostatic effect on Streptococcus mutans ATCC 25175T and bactericidal effects on Streptococcus sobrinus ATCC 33478T at > 2×MIC (70 μg/ml). These results suggest that the propolis can be used in the development of oral hygiene products for the prevention of dental caries.
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Gokben Ozbey, Mustafa Necati Muz, Elif Seren Tanriverdi, Sultan Erkan, Niyazi Bulut, Baris Otlu, František Zigo
Czech Journal of Food Sciences.2023; 41(2): 144. CrossRef - Use of Plant Extracts, Bee-Derived Products, and Probiotic-Related Applications to Fight Multidrug-Resistant Pathogens in the Post-Antibiotic Era
António Machado, Lizbeth Zamora-Mendoza, Frank Alexis, José Miguel Álvarez-Suarez
Future Pharmacology.2023; 3(3): 535. CrossRef - Propolis as Natural Product in the Oral Cavity Bacterial Infections Treatment: A Systematic Review
Michał Otręba, Łukasz Marek, Natalia Tyczyńska, Jerzy Stojko, Anna Kurek-Górecka, Michał Górecki, Paweł Olczyk, Anna Rzepecka-Stojko
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Microorganisms.2021; 9(10): 2041. CrossRef - Antimicrobial activity of a novel Spanish propolis against planktonic and sessile oral Streptococcus spp
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Scientific Reports.2021;[Epub] CrossRef - Antifungal and Antibacterial Effect of Propolis: A Comparative Hit for Food-Borne Pseudomonas, Enterobacteriaceae and Fungi
Leonardo Petruzzi, Maria Rosaria Corbo, Daniela Campaniello, Barbara Speranza, Milena Sinigaglia, Antonio Bevilacqua
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Abhishek Parolia, Haresh Kumar, Srinivasan Ramamurthy, Fabian Davamani, Allan Pau
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Hirotake Oda, Taneaki Nakagawa, Kosuke Maruyama, Yuzuru Dono, Hiroaki Katsuragi, Soh Sato
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Tânia Mara da SILVA, Beatriz Maria da FONSECA, Ana Luísa Leme Simões SALES, Priscila HOLLEBEN, Márcia Carneiro VALERA, Maria Amélia Máximo de ARAÚJO
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Nadine Waldner-Tomic, Rosmarie Vanni, Georgios Belibasakis, Thomas Thurnheer, Thomas Attin, Patrick Schmidlin
Dentistry Journal.2014; 2(3): 85. CrossRef - Determination of optimal concentration of deglycyrrhizinated licorice root extract for preventing dental caries using a bacterial model system
Sug-Joon Ahn, Young-Doo Song, Su-Jung Mah, Eun-Jung Cho, Joong-Ki Kook
Journal of Dental Sciences.2014; 9(3): 214. CrossRef - Antimicrobial Effect of Honey on Streptococcus Mutans of Dental Plaque
NR Yadav, BK Garla, VK Reddy, S Tandon, S Prasad
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Alan Aguiar Lopes, Thiago Santos Ferreira, Renata Tiscoski Nesi, Manuella Lanzetti, Karla Maria Pereira Pires, Ari Miranda Silva, Ricardo Moreira Borges, Antonio Jorge Ribeiro Silva, Samuel Santos Valença, Luís Cristóvão Porto
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Nantiya Joycharat, Sonesay Thammavong, Surasak Limsuwan, Sirilux Homlaead, Supayang Piyawan Voravuthikunchai, Boon-ek Yingyongnarongkul, Sukanya Dej-adisai, Sanan Subhadhirasakul
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Arkadiusz Dziedzic, Robert Kubina, Robert D. Wojtyczka, Agata Kabała-Dzik, Marta Tanasiewicz, Tadeusz Morawiec
Evidence-Based Complementary and Alternative Medicine.2013; 2013: 1. CrossRef - Antimicrobial Effect of Carvacrol against Cariogenic and Periodontopathic Bacteria
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Dianella Savoia
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- Chemical composition, antimicrobial activities, and molecular docking studies of Turkish propolis ethanol extract
- Bacterial Model System for Screening and Determining Optimal Concentration of Anti-caries Natural Extracts
- Min Jung Kim , Chun Sung Kim , Jae-Yoon Park , Soon-Nang Park , So Young Yoo , Sook-Young Lee , Joong-Ki Kook
- J. Microbiol. 2011;49(1):165-168. Published online March 3, 2011
- DOI: https://doi.org/10.1007/s12275-011-1018-0
- 173 View
- 0 Download
- 4 Crossref
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Abstract
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- In general, an antimicrobial test for screening anti-caries natural extracts was performed by measuring the minimum bactericidal concentration (MBC) against the type strains of mutans streptococci. However, it is unclear if the antimicrobial efficiency of natural extracts on the type strains of mutans streptococci is the same on the clinical strains. In this study, we introduced a bacterial model system for the screening of anti-caries and determining the optimal concentration of them to develop oral hygiene products for Korean populations.
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Yun Kyong Lim, So Young Yoo, Soon-Nang Park, Dae Sung Lee, Joong-Ki Kook
International Journal of Oral Biology.2019; 44(3): 101. CrossRef - In vitro Antimicrobial Activities of 1-Methoxyficifolinol, Licorisoflavan A, and 6,8-Diprenylgenistein against Streptococcus mutans
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