Journal of Microbiology

Jun Heo

6 Articles

Comparative genomics of Lactobacillus species as bee symbionts and description of Lactobacillus bombintestini sp. nov., isolated from the gut of Bombus ignitus: Jun Heo , Soo-Jin Kim , Jeong-Seon Kim , Seung-Beom Hong , Soon-Wo Kwon; J. Microbiol. 2020;58(6):445-455. Published online March 28, 2020; DOI: https://doi.org/10.1007/s12275-020-9596-3

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The Lactobacillus genus is widely used for fermentation of plant materials and dairy products. These species are typically found in highly specialized environments, with the bee gut serving as one of the niche locations in which Lactobacillus is detected. Lactobacillus species isolated from the bee gut and bee-related habitats were phylogenetically classified into three distinct groups, Lactobacillus kunkeei, Firm-4, and Firm-5. The L. kunkeei group was clearly differentiated from other members of the Lactobacillus buchneri group isolated from non-bee habitats. In comparison with non-bee members of the L. buchneri group, three bee-symbiotic Lactobacillus groups had a small-sized genome with low G + C content and showed a sharp reduction in the number of genes involved in energy production, carbohydrate transport and metabolism, and amino acid transport and metabolism. In addition, all three groups lacked the mutY gene, which encodes A/G-specific adenine glycosylase. The phylogenetic dendrogram based on the presence or absence of 1,199 functional genes indicated that these bee-symbiotic groups experienced convergent evolution. The occurrence of convergent evolution is thought to stem from the three bee-symbiotic groups sharing a similar habitat, i.e., the bee gut. The causative factor underlying genomic reduction was postulated to be mutY, which was absent in all three groups. Here, a novel strain, BHWM-4T, isolated from the gut of Bombus ignites was studied using polyphasic taxonomy and classified as a new member of the L. kunkeei group. The strain was Gram-positive, facultative anaerobic, and rod-shaped. The 16S ribosomal RNA gene sequence and genome analysis revealed that strain BHWM-4T was clustered into the L. kunkeei group, forming a compact cluster with L. kunkeei and Lactobacillus apinorum. Biochemical, chemotaxonomic, and genotypic data of strain BHWM-4T supports the proposal of a novel species, Lactobacillus bombintestini sp. nov., whose type strain is BHWM-4T (= KACC 19317T = NBRC 113067T).

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List of new names and new combinations that have appeared in effective publications outside of the IJSEM and are submitted for valid publication
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Proposal to reclassify four Lactobacillus species as Apilactobacillus bombintestini, Companilactobacillus suantsaicola, Lactiplantibacillus garii and Levilactobacillus suantsaiihabitans
Paola Mattarelli, Giovanna Felis, Charles M. A. P. Franz, Michael G. Gänzle
International Journal of Systematic and Evolutionary Microbiology .2019;[Epub] CrossRef

Paraflavitalea soli gen. nov., sp. nov., isolated from greenhouse soil: Jun Heo , Hang-Yeon Weon , Hayoung Cho , Seung-Beom Hong , Jeong-Seon Kim , Soo-Jin Kim , Soon-Wo Kwon; J. Microbiol. 2020;58(1):17-23. Published online November 23, 2019; DOI: https://doi.org/10.1007/s12275-020-9236-y

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A bacterial strain designated 5GH32-13T was isolated from greenhouse soil in Yongin-city, Republic of Korea. Cells were Gram-stain-negative, strictly aerobic, motile rods of two different shapes. The strain was catalase-positive and oxidasenegative. Flexirubin-like pigments were not detected. β-Carotene was produced. The strain grew in the range of 10–37°C (optimum of 28–30°C) and pH 6–8 (optimum of pH 7) and tolerated up to 1% (w/v) NaCl (optimum of 0%). According to the 16S rRNA gene sequence comparison, strain 5GH32- 13T shared a sequence similarity of less than 96.0% with all validly named taxa, having the highest sequence similarity with Pseudoflavitalea soli KIS20-3T (95.8%), Pseudoflavitalea rhizosphaerae T16R-265T (95.4%), Flavitalea gansuensis JCN-23T (95.3%), Pseudobacter ginsenosidimutans Gsoil 221T (95.3%), and Flavitalea populi HY-50RT (95.2%). A phylogenetic tree showed that strain 5GH32-13T was not grouped consistently into any specific genus. Its only polyamine was homospermidine, and its major fatty acids (> 10% of total fatty acids) were iso-C15:0, iso-C17:0 3-OH, and iso-C15:1 G. The strain’s only respiratory quinone was MK-7, and its polar lipids were phosphatidylethanolamine, one unidentified phospholipid, six unidentified aminolipids and four unidentified lipids. Its DNA G + C content was 47.5 mol%. The results from chemotaxonomic, phenotypic and phylogenetic analyses indicated that strain 5GH32-13T represents a novel species of a novel genus of the family Chitinophagaceae, and the name Paraflavitalea soli gen. nov., sp. nov. is proposed. The type strain is 5GH32-13T (= KACC 17331T = JCM 33061T).

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International Journal of Systematic and Evolutionary Microbiology .2021;[Epub] CrossRef
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DBA/2 Mouse as an Animal Model for Anti-influenza Drug Efficacy Evaluation: Jin Il Kim , Sehee Park , Sangmoo Lee , Ilseob Lee , Jun Heo , Min-Woong Hwang , Joon-Yong Bae , Donghwan Kim , Seok-Il Jang , Mee Sook Park , Man-Seong Park; J. Microbiol. 2013;51(6):866-871. Published online December 19, 2013; DOI: https://doi.org/10.1007/s12275-013-3428-7

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Influenza viruses are seasonally recurring human pathogens. Vaccines and antiviral drugs are available for influenza. However, the viruses, which often change themselves via antigenic drift and shift, demand constant efforts to update vaccine antigens every year and develop new agents with broad-spectrum antiviral efficacy. An animal model is critical for such efforts. While most human influenza viruses are unable to kill BALB/c mice, some strains have been shown to kill DBA/2 mice without prior adaptation. Therefore, in this study, we explored the feasibility of employing DBA/2 mice as a model in the development of anti-influenza drugs. Unlike the BALB/c strain, DBA/2 mice were highly susceptible and could be killed with a relatively low titer (50% DBA/2 lethal dose = 102.83 plaque-forming units) of the A/ Korea/01/2009 virus (2009 pandemic H1N1 virus). When treated with a neuraminidase inhibitor, oseltamivir phosphate, infected DBA/2 mice survived until 14 days postinfection. The reduced morbidity of the infected DBA/2 mice was also consistent with the oseltamivir treatment. Taking these data into consideration, we propose that the DBA/2 mouse is an excellent animal model to evaluate antiviral efficacy against influenza infection and can be further utilized for combination therapies or bioactivity models of existing and newly developed anti-influenza drugs.

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Swine influenza A virus isolates containing the pandemic H1N1 origin matrix gene elicit greater disease in the murine model
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International Immunopharmacology.2021; 98: 107887. CrossRef
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Gautham K Rao, Rodney A Prell, Steven T Laing, Stefanie C M Burleson, Allen Nguyen, Jacqueline M McBride, Crystal Zhang, Daniel Sheinson, Wendy G Halpern
Toxicological Sciences.2019; 169(2): 409. CrossRef
Targeting the proviral host kinase, FAK, limits influenza a virus pathogenesis and NFkB-regulated pro-inflammatory responses
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Journal of Microbiology.2018; 56(2): 145. CrossRef
Alternative Strategy for a Quadrivalent Live Attenuated Influenza Virus Vaccine
Zhimin Wan, Stivalis Cardenas Garcia, Jing Liu, Jefferson Santos, Silvia Carnaccini, Ginger Geiger, Lucas Ferreri, Daniela Rajao, Daniel R. Perez, Adolfo García-Sastre
Journal of Virology.2018;[Epub] CrossRef
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David Ernszt, Krisztina Banfai, Zoltan Kellermayer, Attila Pap, Janet M. Lord, Judit E. Pongracz, Krisztian Kvell
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Journal of Virology.2015; 89(15): 7841. CrossRef
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Proceedings of the National Academy of Sciences.2015; 112(35): 10890. CrossRef
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Journal of Microbiology.2014; 52(8): 696. CrossRef
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PLoS ONE.2014; 9(7): e101325. CrossRef

The Anti-influenza Virus Effect of Phellinus igniarius Extract: Sangmoo Lee , Jin Il Kim , Jun Heo , Ilseob Lee , Sehee Park , Min-Woong Hwang , Joon-Yong Bae , Mee Sook Park , Hyoung Jin Park , Man-Seong Park; J. Microbiol. 2013;51(5):676-681. Published online October 31, 2013; DOI: https://doi.org/10.1007/s12275-013-3384-2

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Herbal medicine has been used in the orient for thousands of years to treat large and small ailments, including microbial infections. Although there are treatments for influenza virus infection, there is no treatment for drug-resistant viruses. It is time that we explored and exploited the multicomponent nature of herbal extracts as multi-drug combination therapies. Here, we present data on the anti-influenza virus effect of a medicinal mushroom, Phellinus igniarius. The P. igniarius water extract was effective against influenza A and B viruses, including 2009 pandemic H1N1, human H3N2, avian H9N2, and oseltamivir-resistant H1N1 viruses. Virological assays revealed that the extract may interfere with one or more early events in the influenza virus replication cycle, including viral attachment to the target cell. Therefore, our results provide new insights into the use of P. igniarius as an anti-influenza medicine.

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Journal of Computational Biophysics and Chemistry.2026; 25(03): 347. CrossRef
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Chinese Journal of Organic Chemistry.2025; 45(8): 3033. CrossRef
Antiviral Activity of Some Compounds of Gasteroid Mushrooms from Western Siberia
Elena V. Makarevich, Tamara V. Teplyakova, Oleg Yu. Mazurkov, Ekaterina I. Filippova, Natalia A. Mazurkova
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Comparative genomics and stable isotope analysis reveal the saprotrophic-pathogenic lifestyle of a neotropical fungus
Luiz Marcelo Ribeiro Tomé, Gabriel Quintanilha-Peixoto, Diogo Henrique Costa-Rezende, Carlos A. Salvador-Montoya, Domingos Cardoso, Daniel S. Araújo, Jorge Marcelo Freitas, Gabriela Bielefeld Nardoto, Genivaldo Alves-Silva, Elisandro Ricardo Drechsler-San
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Antiviral properties of lignicolous fungi of Serbia
Zlatan Radulović, Dragan Karadžić, Ivan Milenković, Katarina Mladenović, Jelena Božović
Sustainable Forestry: Collection.2023; (87-88): 197. CrossRef
Medicinal mushrooms: a comprehensive study on their antiviral potential
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Identification of potential edible mushroom as SARS-CoV-2 main protease inhibitor using rational drug designing approach
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Anti-Gout Effects of the Medicinal Fungus Phellinus igniarius in Hyperuricaemia and Acute Gouty Arthritis Rat Models
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Phenolic compounds of Phellinus spp. with antibacterial and antiviral activities
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Brazilian Journal of Microbiology.2022; 53(3): 1187. CrossRef
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Applied Biochemistry and Microbiology.2020; 56(5): 489. CrossRef
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Applied Biochemistry and Biotechnology.2020; 190(2): 584. CrossRef
Anti-feline immunodeficiency virus reverse transcriptase properties of some medicinal and edible mushrooms
Supaphorn Seetaha, Siriluk Ratanabunyong, Lueacha Tabtimmai, Kiattawee Choowongkomon, Jatuporn Rattanasrisomporn, Khuanjarat Choengpanya
Veterinary World.2020; 13(9): 1798. CrossRef
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International Journal of Biological Macromolecules.2019; 123: 157. CrossRef
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Jinjing Guo, Cheng Liu, Caifang Zhang, Jing Wang, Sa Wang, Xiaoxi Liu, Xiaojuan Gao, Xiuli Wu
Food Science and Technology Research.2019; 25(3): 459. CrossRef
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Medicinal mushroom Phellinus igniarius induced cell apoptosis in gastric cancer SGC-7901 through a mitochondria-dependent pathway
Fei-Fei Wang, Chao Shi, Yue Yang, Yong Fang, Li Sheng, Ning Li
Biomedicine & Pharmacotherapy.2018; 102: 18. CrossRef
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The American Journal of Chinese Medicine.2018; 46(08): 1663. CrossRef
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PLOS ONE.2016; 11(9): e0163797. CrossRef
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Bioresource Technology.2016; 205: 48. CrossRef
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Journal of Molecular Catalysis B: Enzymatic.2016; 134: 186. CrossRef
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PLoS ONE.2014; 9(7): e101325. CrossRef

NOTE] Susceptibility of Human H3N2 Influenza Virus to Oseltamivir in South Korea, 2009–2011: Sehee Park , Jin Il Kim , Ilseob Lee , Sangmoo Lee , Min-Woong Hwang , Joon-Yong Bae , Jun Heo , Eun-Joo Lim , Won-Seok Seok , Hee Jin Cheong , Joon Young Song , Woo Joo Kim , Man-Seong Park; J. Microbiol. 2012;50(6):1067-1070. Published online December 30, 2012; DOI: https://doi.org/10.1007/s12275-012-2541-3

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During the 2009–2011 influenza seasons, 10.26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays.

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NOTE] GFP-Expressing Influenza A Virus for Evaluation of the Efficacy of Antiviral Agents: Jin Il Kim , Sehee Park , Ilseob Lee , Sangmoo Lee , Saem Shin , Yongkwan Won , Min-Woong Hwang , Joon-Yong Bae , Jun Heo , Hye-Eun Hyun , Hyejin Jun , Soon Sung Lim , Man-Seong Park; J. Microbiol. 2012;50(2):359-362. Published online April 27, 2012; DOI: https://doi.org/10.1007/s12275-012-2163-9

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To address its value as a screening tool in the development of antiviral drugs, a recombinant influenza virus expressing green fluorescent protein (rPR8-GFP virus) was investigated in vitro and in vivo. The inhibition of viral growth by a neuraminidase inhibitor in the cells or lower respiratory tracts of mice could be visualized by the level of fluorescence. In addition, the rPR8-GFP virus exhibited high pathogenicity in mice. Taken together, these results suggest that the rPR8-GFP virus can be a useful tool for the rapid identification of antiviral drugs active against influenza viruses.

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