Journal of Microbiology

Chun Lin

1 Article

Minor and major circRNAs in virus and host genomes: Zhihao Lou , Rui Zhou , Yinghua Su , Chun Liu , Wenting Ruan , Che Ok Jeon , Xiao Han , Chun Lin , Baolei Jia; J. Microbiol. 2021;59(3):324-331. Published online February 23, 2021; DOI: https://doi.org/10.1007/s12275-021-1021-z

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As a special type of noncoding RNA, circular RNAs (circRNAs) are prevalent in many organisms. They can serve as sponges for microRNAs and protein scaffolds, or templates for protein translation, making them linked to cellular homeostasis and disease progression. In recent years, circRNAs have been found to be abnormally expressed during the processes of viral infection and pathogenesis, and can help a virus escape the immune response of a host. Thus, they are now considered to play important functions in the invasion and development of viruses. Moreover, the potential application of circRNAs as biomarkers of viral infection or candidates for therapeutic targeting deserves consideration. This review summarizes circRNAs in the transcriptome, including their classification, production, functions, and value as biomarkers. This review paper also describes research progress on circRNAs in viral infection (mainly hepatitis B virus, HIV, and some human herpes viruses) and aims to provide new ideas for antiviral therapies targeting circRNAs.

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Host combats porcine reproductive and respiratory syndrome virus infection at non-coding RNAs level
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Circ_0138959/miR-495-3p/TRAF6 axis regulates proliferation, wound healing and osteoblastic differentiation of periodontal ligament cells in periodontitis
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Chun Lin

1 Article

Gut Microbiota Dysbiosis Facilitates Susceptibility to Bloodstream Infection: Xiaomin Lin, Chun Lin, Xin Li, Fen Yao, Xiaoling Guo, Meimei Wang, Mi Zeng, Yumeng Yuan, Qingdong Xie, Xudong Huang, Xiaoyang Jiao; J. Microbiol. 2024;62(12):1113-1124. Published online December 2, 2024; DOI: https://doi.org/10.1007/s12275-024-00190-5

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Abstract: To study the role of intestinal flora in the development of bloodstream infections (BSIs). 42 patients and 19 healthy controls (HCs) were screened into the study and their intestinal flora was measured by 16S rRNA gene sequencing. The bacterial diversity was significantly lower in the BSI group compared with that in the HCs (P < 0.001), and beta diversity was significantly differentiated between the two groups (PERMANOVA, P = 0.001). The four keystone species [Roseburia, Faecalibacterium, Prevotella, and Enterococcus (LDA > 4)] differed significantly between the two groups. Dysbiosis of fecal microbial ecology is a common condition present in patients with BSI. The proliferation of certain pathogens or reduction of SCFA-producing bacteria would cause susceptibility to BSI.

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