Journal of Microbiology

Journal Articles

Mycobacterium tuberculosis PE_PGRS45 (Rv2615c) Promotes Recombinant Mycobacteria Intracellular Survival via Regulation of Innate Immunity, and Inhibition of Cell Apoptosis: Tao Xu , Chutong Wang , Minying Li , Jing Wei , Zixuan He , Zhongqing Qian , Xiaojing Wang , Hongtao Wang; J. Microbiol. 2024;62(1):49-62. Published online February 9, 2024; DOI: https://doi.org/10.1007/s12275-023-00101-0

67 View
0 Download
2 Web of Science
3 Crossref

Tuberculosis (TB), a bacterial infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis), is a significant global public health problem. Mycobacterium tuberculosis expresses a unique family of PE_PGRS proteins that have been implicated in pathogenesis. Despite numerous studies, the functions of most PE_PGRS proteins in the pathogenesis of mycobacterium infections remain unclear. PE_PGRS45 (Rv2615c) is only found in pathogenic mycobacteria. In this study, we successfully constructed a recombinant Mycobacterium smegmatis (M. smegmatis) strain which heterologously expresses the PE_PGRS45 protein. We found that overexpression of this cell wall-associated protein enhanced bacterial viability under stress in vitro and cell survival in macrophages. MS_PE_PGRS45 decreased the secretion of pro-inflammatory cytokines such as IL-1β, IL-6, IL-12p40, and TNF-α. We also found that MS_PE_PGRS45 increased the expression of the anti-inflammatory cytokine IL-10 and altered macrophage-mediated immune responses. Furthermore, PE_PGRS45 enhanced the survival rate of M. smegmatis in macrophages by inhibiting cell apoptosis. Collectively, our findings show that PE_PGRS45 is a virulent factor actively involved in the interaction with the host macrophage.

Citations

Citations to this article as recorded by

Evolution of the PE_PGRS Proteins of Mycobacteria: Are All Equal or Are Some More Equal than Others?
Bei Chen, Belmin Bajramović, Bastienne Vriesendorp, Herman Pieter Spaink
Biology.2025; 14(3): 247. CrossRef
Recent advances in research on Mycobacterium tuberculosis virulence factors and their role in pathogenesis
Ming-Rui Sun, Jia-Yin Xing, Xiao-Tian Li, Ren Fang, Yang Zhang, Zhao-Li Li, Ning-Ning Song
Journal of Microbiology, Immunology and Infection.2025;[Epub] CrossRef
Rv2741 Promotes Mycobacterium Survival by Modulating Macrophage Function via the IL-1α-MAPK Axis
Xintong He, Yonglin He, Xichuan Deng, Nan Lu, Anlong Li, Sijia Gao, Shiyan He, Yuran Wang, Nanzhe Fu, Zijie Wang, Yuxin Nie, Lei Xu
ACS Infectious Diseases.2025; 11(3): 676. CrossRef

Adaptation of Pseudomonas helmanticensis to fat hydrolysates and SDS: fatty acid response and aggregate formation: Ilya N. Zubkov , Anatoly P. Nepomnyshchiy , Vadim D. Kondratyev , Pavel N. Sorokoumov , Konstantin V. Sivak , Edward S. Ramsay , Sergey M. Shishlyannikov; J. Microbiol. 2021;59(12):1104-1111. Published online October 26, 2021; DOI: https://doi.org/10.1007/s12275-021-1214-5

55 View
0 Download
3 Web of Science
3 Crossref

Abstract

An essential part of designing any biotechnological process is examination of the physiological state of producer cells in different phases of cultivation. The main marker of a bacterial cell’s state is its fatty acid (FA) profile, reflecting membrane lipid composition. Consideration of FA composition enables assessment of bacterial responses to cultivation conditions and helps biotechnologists understand the most significant factors impacting cellular metabolism. In this work, soil SDS-degrading Pseudomonas helmanticensis was studied at the fatty acid profile level, including analysis of rearrangement between planktonic and aggregated forms. The set of substrates included fat hydrolysates, SDS, and their mixtures with glucose. Such media are useful in bioplastic production since they can help incrementally lower overall costs. Conventional gas chromatography-mass spectrometry was used for FA analysis. Acridine orange-stained aggregates were observed by epifluorescence microscopy. The bacterium was shown to change fatty acid composition in the presence of hydrolyzed fats or SDS. These changes seem to be driven by the depletion of metabolizable substrates in the culture medium. Cell aggregation has also been found to be a defense strategy, particularly with anionic surfactant (SDS) exposure. It was shown that simple fluidity indices (such as saturated/ unsaturated FA ratios) do not always sufficiently characterize a cell's physiological state, and morphological examination is essential in cases where complex carbon sources are used.

Citations

Citations to this article as recorded by

Effect of different diet composition on the fat profile of two different black soldier fly larvae populations
M. Tognocchi, L. Abenaim, C. Adamaki-Sotiraki, G.C. Athanassiou, I.C. Rumbos, M. Mele, B. Conti, G. Conte
animal.2024; 18(7): 101205. CrossRef
Earth to Mars: A Protocol for Characterizing Permafrost in the Context of Climate Change as an Analog for Extraplanetary Exploration
Kimberley R. Miner, Joseph Razzell Hollis, Charles E. Miller, Kyle Uckert, Thomas A. Douglas, Emily Cardarelli, Rachel Mackelprang
Astrobiology.2023; 23(9): 1006. CrossRef
Preparation of polyhydroxyalkanoates using Pseudomonas helmanticensis in non-sterile media containing glycerol and sodium dodecyl sulfate
I. N. Zubkov, Yu. S. Bukin, P. N. Sorokoumov, S. M. Shishlyannikov
Proceedings of Universities. Applied Chemistry and Biotechnology.2022; 12(3): 479. CrossRef

The small RNA RsaF regulates the expression of secreted virulence factors in Staphylococcus aureus Newman: Niralee Patel , Mrinalini Nair; J. Microbiol. 2021;59(10):920-930. Published online September 23, 2021; DOI: https://doi.org/10.1007/s12275-021-1205-6

69 View
0 Download
5 Web of Science
5 Crossref

Abstract

The pathogenesis of Staphylococcus aureus, from local infections to systemic dissemination, is mediated by a battery of virulence factors that are regulated by intricate mechanisms, which include regulatory proteins and small RNAs (sRNAs) as key regulatory molecules. We have investigated the involvement of sRNA RsaF, in the regulation of pathogenicity genes hyaluronate lyase (hysA) and serine proteaselike protein D (splD), by employing S. aureus strains with disruption and overexpression of rsaF. Staphylococcus aureus strain with disruption of rsaF exhibited marked down-regulation of hysA transcripts by 0.2 to 0.0002 fold, and hyaluronate lyase activity by 0.2–0.1 fold, as well as increased biofilm formation, during growth from log phase to stationery phase. These mutants also displayed down-regulation of splD transcripts by 0.8 to 0.005 fold, and reduced activity of multiple proteases by zymography. Conversely, overexpression of rsaF resulted in a 2- to 4- fold increase in hysA mRNA levels and hyaluronidase activity. Both hysA and splD mRNAs demonstrated an increased stability in RsaF+ strains. In silico RNA-RNA interaction indicated a direct base pairing of RsaF with hysA and splD mRNAs, which was established in electrophoretic mobility shift assays. The findings demonstrate a positive regulatory role for small RNA RsaF in the expression of the virulence factors, HysA and SplD.

Citations

Citations to this article as recorded by

Rational Design of High-Efficiency Synthetic Small Regulatory RNAs and Their Application in Robust Genetic Circuit Performance Through Tight Control of Leaky Gene Expression
Jun Ren, Nuong Thi Nong, Phuong N. Lam Vo, Hyang-Mi Lee, Dokyun Na
ACS Synthetic Biology.2024; 13(10): 3256. CrossRef
A comprehensive review on microbial hyaluronan-degrading enzymes: from virulence factors to biotechnological tools
Jia-Yu Jiang, Dai Xue, Jin-Song Gong, Qin-Xin Zheng, Yue-Sheng Zhang, Chang Su, Zheng-Hong Xu, Jin-Song Shi
Bioresources and Bioprocessing.2024;[Epub] CrossRef
A Regulatory sRNA rli41 is Implicated in Cell Adhesion, Invasion and Pathogenicity in Listeria monocytogenes
L. X. Wang, C. H. Ji, C. C. Ning, Y. C. Liu, Z. Y. Li, Y. Q. Sun, X. Z. Xia, X. P. Cai, Q. L. Meng, J. Qiao
Applied Biochemistry and Microbiology.2022; 58(S1): S47. CrossRef
A Review of Biofilm Formation of Staphylococcus aureus and Its Regulation Mechanism
Qi Peng, Xiaohua Tang, Wanyang Dong, Ning Sun, Wenchang Yuan
Antibiotics.2022; 12(1): 12. CrossRef
Thirty Years of sRNA-Mediated Regulation in Staphylococcus aureus: From Initial Discoveries to In Vivo Biological Implications
Guillaume Menard, Chloé Silard, Marie Suriray, Astrid Rouillon, Yoann Augagneur
International Journal of Molecular Sciences.2022; 23(13): 7346. CrossRef

The inner membrane protein LapB is required for adaptation to cold stress in an LpxC-independent manner: Han Byeol Lee , Si Hyoung Park , Chang-Ro Lee; J. Microbiol. 2021;59(7):666-674. Published online May 15, 2021; DOI: https://doi.org/10.1007/s12275-021-1130-8

59 View
0 Download
10 Web of Science
9 Crossref

Abstract

The inner membrane protein lipopolysaccharide assembly protein B (LapB) is an adaptor protein that activates the proteolysis of LpxC by an essential inner membrane metalloprotease, FtsH, leading to a decrease in the level of lipopolysaccharide in the membrane. In this study, we revealed the mechanism by which the essential inner membrane protein YejM regulates LapB and analyzed the role of the transmembrane domain of LapB in Escherichia coli. The transmembrane domain of YejM genetically and physically interacted with LapB and inhibited its function, which led to the accumulation of LpxC. The transmembrane domain of LapB was indispensable for both its physical interaction with YejM and its regulation of LpxC proteolysis. Notably, we found that the lapB mutant exhibited strong cold sensitivity and this phenotype was not associated with increased accumulation of LpxC. The transmembrane domain of LapB was also required for its role in adaptation to cold stress. Taken together, these
results
showed that LapB plays an important role in both the regulation of LpxC level, which is controlled by its interaction with the transmembrane domain of YejM, and adaptation to cold stress, which is independent of LpxC.

Citations

Citations to this article as recorded by

PhoPQ-mediated lipopolysaccharide modification governs intrinsic resistance to tetracycline and glycylcycline antibiotics in Escherichia coli
Byoung Jun Choi, Umji Choi, Dae-Beom Ryu, Chang-Ro Lee, Mehrad Hamidian, You-Hee Cho
mSystems.2024;[Epub] CrossRef
Lytic transglycosylase repertoire diversity enables intrinsic antibiotic resistance and daughter cell separation in Escherichia coli under acidic stress
Ji Eun Son, Si Hyoung Park, Umji Choi, Chang-Ro Lee, Laurent Poirel
Antimicrobial Agents and Chemotherapy.2024;[Epub] CrossRef
Trans-cinnamaldehyde inhibits Escherichia coli growth by regulating lipopolysaccharide accumulation
Huanling Xing, Xiaomin Liu, Jianhao Lin, Mingfei Sun, Junyi Huang, Xinghai Li, Yanqun Li, Shining Guo, Fang Zhou, Hong Wu
Food Bioscience.2024; 61: 104559. CrossRef
Coordinated and Distinct Roles of Peptidoglycan Carboxypeptidases DacC and DacA in Cell Growth and Shape Maintenance under Stress Conditions
Umji Choi, Si Hyoung Park, Han Byeol Lee, Ji Eun Son, Chang-Ro Lee, Cristina Solano
Microbiology Spectrum.2023;[Epub] CrossRef
NoiD, a DedA membrane protein required for homeostasis maintaining of Rhizobium leguminosarum biovar viciae during symbiosis with Pisum sativum
Xiaofang Li, Jiaming Xu, Yajuan Wei, Zirui Chen
Symbiosis.2022; 86(1): 81. CrossRef
Conserved Tandem Arginines for PbgA/YejM Allow Salmonella Typhimurium To Regulate LpxC and Control Lipopolysaccharide Biogenesis during Infection
Nicole P. Giordano, Joshua A. Mettlach, Zachary D. Dalebroux, Manuela Raffatellu
Infection and Immunity.2022;[Epub] CrossRef
Divergent Effects of Peptidoglycan Carboxypeptidase DacA on Intrinsic β-Lactam and Vancomycin Resistance
Si Hyoung Park, Umji Choi, Su-Hyun Ryu, Han Byeol Lee, Jin-Won Lee, Chang-Ro Lee, Krisztina M. Papp-Wallace
Microbiology Spectrum.2022;[Epub] CrossRef
Cryo-EM structure of transmembrane AAA+ protease FtsH in the ADP state
Wu Liu, Martien Schoonen, Tong Wang, Sean McSweeney, Qun Liu
Communications Biology.2022;[Epub] CrossRef
Checkpoints That Regulate Balanced Biosynthesis of Lipopolysaccharide and Its Essentiality in Escherichia coli
Gracjana Klein, Alicja Wieczorek, Martyna Szuster, Satish Raina
International Journal of Molecular Sciences.2021; 23(1): 189. CrossRef

Autophagic elimination of Trypanosoma cruzi in the presence of metals: Laís Pessanha de Carvalho , Edésio José Tenório de Melo; J. Microbiol. 2019;57(10):918-926. Published online August 28, 2019; DOI: https://doi.org/10.1007/s12275-019-9018-6

49 View
0 Download
3 Web of Science
3 Crossref

Abstract

Trypanosoma cruzi is an obligate intracellular parasite transmitted to vertebrate hosts by blood-sucking insects. Molecules present in parasites and mammalian cells allow the recognition and parasite internalization. Metallic ions play an essential role in the establishment and maintenance of hostparasite interaction. However, little is known about how parasites handle with essential and nonessential metal quotas. This study aimed to investigate the influence of metal ions on the biological processes of T. cruzi infected cells. Infected cells were incubated with ZnCl2, CdCl2, and HgCl2 for 12 h and labeled with different specific dyes to investigate the cellular events related to intracellular parasite death and elimination. Infected host cells and parasite’s mitochondria underwent functional and structural disorders, in addition to parasite’s DNA condensation and pH decrease on host cells, which led to parasite death. Further investigations suggested that lysosomes were involved in pH decrease and the double membrane of the endoplasmic reticulum formed vacuoles surrounding damaged parasites, which indicate the occurrence of autophagy for parasite elimination. In conclusion, low concentrations of nonessential and essential metals cause a series of damage to Trypanosoma cruzi organelles, leading to its loss of viability, death, and elimination, with no removal of the host cells.

Citations

Citations to this article as recorded by

The role of host autophagy in intracellular protozoan parasites diseases
Rafael Cardoso Maciel Costa Silva, Jhones Sousa Ribeiro, Thalita Santos de Moraes de Farias, Leonardo Holanda Travassos
Archives of Biochemistry and Biophysics.2024; 761: 110186. CrossRef
Personalized Prevention in Mercury-Induced Amyotrophic Lateral Sclerosis: A Case Report
Nicola Magnavita, Mario Sabatelli, Egeria Scoditti, Francesco Chirico
Applied Sciences.2020; 10(21): 7839. CrossRef
Essential and nonessential metal effects on extracellular Leishmania amazonensis in vitro
Laís Pessanha de Carvalho, Jana Held, Edésio José Tenório de Melo
Experimental Parasitology.2020; 209: 107826. CrossRef

Vacuolar zinc transporter Zrc1 is required for detoxification of excess intracellular zinc in the human fungal pathogen Cryptococcus neoformans: Minsu Cho , Guanggan Hu , Mélissa Caza , Linda C. Horianopoulos , James W. Kronstad , Won Hee Jung; J. Microbiol. 2018;56(1):65-71. Published online January 4, 2018; DOI: https://doi.org/10.1007/s12275-018-7475-y

51 View
0 Download
11 Crossref

Abstract

Zinc is an important transition metal in all living organisms and is required for numerous biological processes. However, excess zinc can also be toxic to cells and cause cellular stress. In the model fungus Saccharomyces cerevisiae, a vacuolar zinc transporter, Zrc1, plays important roles in the storage and detoxification of excess intracellular zinc to protect the cell. In this study, we identified an ortholog of the S. cerevisiae ZRC1 gene in the human fungal pathogen Cryptococcus neoformans. Zrc1 was localized in the vacuolar membrane in C. neoformans, and a mutant lacking ZRC1 showed significant growth defects under high-zinc conditions. These results suggested a role for Zrc1 in zinc detoxification. However, contrary to our expectation, the expression of Zrc1 was induced in cells grown in zinc-limited conditions and decreased upon the addition of zinc. These expression patterns were similar to those of Zip1, the high-affinity zinc transporter in the plasma membrane of C. neoformans. Furthermore, we used the zrc1 mutant in a murine model of cryptococcosis to examine whether a mammalian host could inhibit the survival of C. neoformans using zinc toxicity. We found that the mutant showed no difference in virulence compared with the wildtype strain. This result suggests that Zrc1-mediated zinc detoxification is not required for the virulence of C. neoformans, and imply that zinc toxicity may not be an important aspect of the host immune response to the fungus.

Citations

Citations to this article as recorded by

CDF family of zinc transporters ZRC-1, MSC-2, and ZRG-17 are involved in survival at high zinc conditions, vegetative development, and cellulase utilization in Neurospora crassa
Serena Ngiimei D, Ranjan Tamuli
Journal of Biosciences.2024;[Epub] CrossRef
“We've got to get out”—Strategies of human pathogenic fungi to escape from phagocytes
Johannes Sonnberger, Lydia Kasper, Theresa Lange, Sascha Brunke, Bernhard Hube
Molecular Microbiology.2024; 121(3): 341. CrossRef
Zinc Starvation Induces Cell Wall Remodeling and Activates the Antioxidant Defense System in Fonsecaea pedrosoi
Tayná Aparecida de Oliveira Santos, Lucas Weba Soares, Lucas Nojosa Oliveira, Dayane Moraes, Millena Silva Mendes, Célia Maria de Almeida Soares, Alexandre Melo Bailão, Mirelle Garcia Silva Bailão
Journal of Fungi.2024; 10(2): 118. CrossRef
Characterization and functional analysis of zinc trafficking in the human fungal pathogen Candida parapsilosis
Tamás Takács, Mihály Tibor Németh, Flóra Bohner, Csaba Vágvölgyi, Ferenc Jankovics, Duncan Wilson, Attila Gácser
Open Biology.2022;[Epub] CrossRef
Fungal–Metal Interactions: A Review of Toxicity and Homeostasis
Janelle R. Robinson, Omoanghe S. Isikhuemhen, Felicia N. Anike
Journal of Fungi.2021; 7(3): 225. CrossRef
Zinc at the Host–Fungus Interface: How to Uptake the Metal?
Lucas Weba Soares, Alexandre Melo Bailão, Célia Maria de Almeida Soares, Mirelle Garcia Silva Bailão
Journal of Fungi.2020; 6(4): 305. CrossRef
Transcription factors and transporters in zinc homeostasis: lessons learned from fungi
David J. Eide
Critical Reviews in Biochemistry and Molecular Biology.2020; 55(1): 88. CrossRef
RNase G controls tpiA mRNA abundance in response to oxygen availability in Escherichia coli
Jaejin Lee, Dong-Ho Lee, Che Ok Jeon, Kangseok Lee
Journal of Microbiology.2019; 57(10): 910. CrossRef
The coordinated action of RNase III and RNase G controls enolase expression in response to oxygen availability in Escherichia coli
Minho Lee, Minju Joo, Minji Sim, Se-Hoon Sim, Hyun-Lee Kim, Jaejin Lee, Minkyung Ryu, Ji-Hyun Yeom, Yoonsoo Hahn, Nam-Chul Ha, Jang-Cheon Cho, Kangseok Lee
Scientific Reports.2019;[Epub] CrossRef
TheAspergillus fumigatustranscription factor AceA is involved not only in Cu but also in Zn detoxification through regulating transporters CrpA and ZrcA
Zhendong Cai, Wenlong Du, Zheng Zhang, Luyu Guan, Qiuqiong Zeng, Yanfei Chai, Chuanchao Dai, Ling Lu
Cellular Microbiology.2018; 20(10): e12864. CrossRef
Biphasic zinc compartmentalisation in a human fungal pathogen
Aaron C. Crawford, Laura E. Lehtovirta-Morley, Omran Alamir, Maria J. Niemiec, Bader Alawfi, Mohammad Alsarraf, Volha Skrahina, Anna C. B. P. Costa, Andrew Anderson, Sujan Yellagunda, Elizabeth R. Ballou, Bernhard Hube, Constantin F. Urban, Duncan Wilson,
PLOS Pathogens.2018; 14(5): e1007013. CrossRef

Metabolism-mediated induction of zinc tolerance in Brassica rapa by Burkholderia cepacia CS2-1: Sang-Mo Kang , Raheem Shahzad , Saqib Bilal , Abdul Latif Khan , Young-Hyun You , Won-Hee Lee , Hee-La Ryu , Ko-Eun Lee , In-Jung Lee; J. Microbiol. 2017;55(12):955-965. Published online December 7, 2017; DOI: https://doi.org/10.1007/s12275-017-7305-7

55 View
0 Download
12 Crossref

Abstract

Brassica rapa (Chinese cabbage) is an essential component of traditional Korean food. However, the crop is often subject to zinc (Zn+) toxicity from contaminated irrigation water, which, as a result, compromises plant growth and production, as well as the health of human consumers. The present study investigated the bioaccumulation of Zn+ by Burkholderia cepacia CS2-1 and its effect on the heavy metal tolerance of Chinese cabbage. Strain CS2-1 was identified and characterized on the basis of 16S rRNA sequences and phylogenetic analysis. The strain actively produced indole-3-acetic acid (3.08 ± 0.21 μg/ml) and was also able to produce siderophore, solubilize minerals, and tolerate various concentrations of Zn+. The heavy metal tolerance of B. rapa plants was enhanced by CS2-1 inoculation, as indicated by growth attributes, Zn+ uptake, amino acid synthesis, antioxidant levels, and endogenous hormone (ABA and SA) synthesis. Without inoculation, the application of Zn+ negatively affected the growth and physiology of B. rapa plants. However, CS2-1 inoculation improved plant growth, lowered Zn+ uptake, altered both amino acid regulation and levels of flavonoids and phenolics, and significantly decreased levels of superoxide dismutase, endogenous abscisic acid, and salicylic acid. These findings indicate that B. cepacia CS2-1 is suitable for bioremediation against Zn+-induced oxidative stress.

Citations

Citations to this article as recorded by

Assessing the health of climate-sensitive trees in a subalpine ecosystem through microbial community dynamics
Bo Ram Kang, Soo Bin Kim, Jin-Kyung Hong, Seok Hyun Ahn, Jinwon Kim, Nayeon Lee, Tae Kwon Lee
Science of The Total Environment.2024; 957: 177724. CrossRef
Exploring the Phosphate Solubilising Rhizobacteria isolated from Wild Musa Rhizosphere and their Efficacy on Growth Promotion of Phaseolus vulgaris
Mum Tatung, Chitta Ranjan Deb
Journal of Experimental Biology and Agricultural Sciences.2024; 12(5): 742. CrossRef
Remediation of benzo[a]pyrene contaminated soils by moderate chemical oxidation coupled with microbial degradation
Bin Chen, Jiang Xu, Huijie Lu, Lizhong Zhu
Science of The Total Environment.2023; 871: 161801. CrossRef
Assessing the Involvement of Selected Phenotypes of Pseudomonas simiae PICF7 in Olive Root Colonization and Biological Control of Verticillium dahliae
Nuria Montes-Osuna, Carmen Gómez-Lama Cabanás, Antonio Valverde-Corredor, Roeland L. Berendsen, Pilar Prieto, Jesús Mercado-Blanco
Plants.2021; 10(2): 412. CrossRef
Ameliorative effect of indole-3-acetic acid- and siderophore-producing Leclercia adecarboxylata MO1 on cucumber plants under zinc stress
Sang-Mo Kang, Raheem Shahzad, Muhammad Aaqil Khan, Zuhair Hasnain, Ko-Eun Lee, Hee-Soon Park, Lee-Rang Kim, In-Jung Lee
Journal of Plant Interactions.2021; 16(1): 30. CrossRef
Cadmium stress triggers significant metabolic reprogramming in Enterococcus faecium CX 2–6
Xin Cheng, Bowen Yang, Jinfang Zheng, Hongyu Wei, Xuehuan Feng, Yanbin Yin
Computational and Structural Biotechnology Journal.2021; 19: 5678. CrossRef
Complete Genome Sequence of Pseudomonas psychrotolerans CS51, a Plant Growth-Promoting Bacterium, Under Heavy Metal Stress Conditions
Sang-Mo Kang, Sajjad Asaf, Abdul Latif Khan, Lubna, Adil Khan, Bong-Gyu Mun, Muhammad Aaqil Khan, Humaira Gul, In-Jung Lee
Microorganisms.2020; 8(3): 382. CrossRef
The plant-growth promoting bacteria promote cadmium uptake by inducing a hormonal crosstalk and lateral root formation in a hyperaccumulator plant Sedum alfredii
Yingjie Wu, Luyao Ma, Qizhen Liu, Mette Vestergård, Olivera Topalovic, Qiong Wang, Qiyao Zhou, Lukuan Huang, Xiaoe Yang, Ying Feng
Journal of Hazardous Materials.2020; 395: 122661. CrossRef
Effect of Ammonia and Indole-3-acetic Acid Producing Endophytic Klebsiella pneumoniae YNA12 as a Bio-Herbicide for Weed Inhibition: Special Reference with Evening Primroses
Sang-Mo Kang, Saqib Bilal, Raheem Shahzad, Yu-Na Kim, Chang-Wook Park, Ko-Eun Lee, Jeong-Ran Lee, In-Jung Lee
Plants.2020; 9(6): 761. CrossRef
Potential role of plant growth-promoting bacteria in Miscanthus x giganteus phytotechnology applied to the trace elements contaminated soils
Valentina Pidlisnyuk, Aigerim Mamirova, Kumar Pranaw, Pavlo Y. Shapoval, Josef Trögl, Asil Nurzhanova
International Biodeterioration & Biodegradation.2020; 155: 105103. CrossRef
Phytohormones enabled endophytic Penicillium funiculosum LHL06 protects Glycine max L. from synergistic toxicity of heavy metals by hormonal and stress-responsive proteins modulation
Saqib Bilal, Raheem Shahzad, Abdul Latif Khan, Ahmed Al-Harrasi, Chang Kil Kim, In-Jung Lee
Journal of Hazardous Materials.2019; 379: 120824. CrossRef
Amelioration of heavy metal stress by endophytic Bacillus amyloliquefaciens RWL-1 in rice by regulating metabolic changes: potential for bacterial bioremediation
Raheem Shahzad, Saqib Bilal, Muhammad Imran, Abdul Latif Khan, Areej Ahmed Alosaimi, Hussah Abdullah Al-Shwyeh, Hanan Almahasheer, Suriya Rehman, In-Jung Lee
Biochemical Journal.2019; 476(21): 3385. CrossRef

Research Support, Non-U.S. Gov'ts

Negative regulation of the vacuole-mediated resistance to K+ stress by a novel C2H2 zinc finger transcription factor encoded by aslA in Aspergillus nidulans: Dong Soo Park , Yeong Man Yu , Yong Jin Kim , Pil Jae Maeng; J. Microbiol. 2015;53(2):100-110. Published online January 28, 2015; DOI: https://doi.org/10.1007/s12275-015-4701-8

58 View
0 Download
16 Crossref

Abstract

In fungi and plants, vacuoles function as a storage and sequestration vessel for a wide variety of ions and are responsible for cytosolic ion homeostasis and responses to ionic shock. In the filamentous fungus Aspergillus nidulans, however, little is known about the molecular genetic mechanisms of vacuolar biogenesis and function. In the present study, we analyzed the function of the aslA gene (AN5583) encoding a novel C2H2-type zinc finger transcription factor (TF) in relation to K+ stress resistance, vacuolar morphology, and vacuolar transporters. The mutant lacking aslA showed increased mycelial growth and decreased branching at high K+ concentrations. Deletion of aslA also caused elevated K+ stress-inducible expression of the genes, nhxA (AN2288), vnxA (AN6986), and vcxA (AN0471), encoding putative endosomal and vacuolar cation/H+ exchangers, as well as cpyA and vpsA genes encoding the proteins involved in vacuolar biogenesis. Interestingly, vacuolar fragmentation induced by K+ stress was alleviated by aslA deletion, resulting in persistence of unfragmented vacuoles. In the presence of bafilomycin, an inhibitor of vacuolar H+-ATPase, the mutant phenotype was suppressed in terms of growth rates and vacuolar morphology. These results together suggest that the C2H2- type zinc finger TF AslA attenuates the K+ stress-inducible expression of the genes encoding the ion pumps involved in vacuolar sequestration of K+ ions powered by vacuolar H+- ATPase, as well as the proteins that function in vacuolar biogenesis.

Citations

Citations to this article as recorded by

The pleiotropic phenotype of FlbA of Aspergillus niger is explained in part by the activity of seven of its downstream-regulated transcription factors
Xiaoyi Chen, Juan P. Moran Torres, Peter Jan Vonk, J. Mirjam A. Damen, Karli R. Reiding, Jan Dijksterhuis, Luis G. Lugones, Han A.B. Wösten
Fungal Genetics and Biology.2024; 172: 103894. CrossRef
Survival Factor A (SvfA) Contributes to Aspergillus nidulans Pathogenicity
Joo-Yeon Lim, Ye-Eun Jung, Hye-Eun Hwang, Cheol-Hee Kim, Nese Basaran-Akgul, Sri Harshini Goli, Steven P. Templeton, Hee-Moon Park
Journal of Fungi.2023; 9(2): 143. CrossRef
A C2H2 Zinc Finger Protein PlCZF1 Is Necessary for Oospore Development and Virulence in Peronophythora litchii
Honghui Zhu, Junjian Situ, Tianfang Guan, Ziyuan Dou, Guanghui Kong, Zide Jiang, Pinggen Xi
International Journal of Molecular Sciences.2022; 23(5): 2733. CrossRef
The Gβ-like Protein AfCpcB Affects Sexual Development, Response to Oxidative Stress and Phagocytosis by Alveolar Macrophages in Aspergillus fumigatus
Joo-Yeon Lim, Yeon-Ju Kim, Hee-Moon Park
Journal of Fungi.2022; 8(1): 56. CrossRef
Characterization of BbKlf1 as a novel transcription factor vital for asexual and infection cycles of Beauveria bassiana
Rehab Abdelmonem Mohamed, Chong‐Tao Guo, Si‐Yuan Xu, Sheng‐Hua Ying, Ming‐Guang Feng
Environmental Microbiology Reports.2022; 14(5): 719. CrossRef
The LAMMER Kinase, LkhA, Affects Aspergillus fumigatus Pathogenicity by Modulating Reproduction and Biosynthesis of Cell Wall PAMPs
Joo-Yeon Lim, Yeon Ju Kim, Seul Ah Woo, Jae Wan Jeong, Yu-Ri Lee, Cheol-Hee Kim, Hee-Moon Park
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef
Mannitol-1-phosphate dehydrogenase, MpdA, is required for mannitol production in vegetative cells and involved in hyphal branching, heat resistance of conidia and sexual development in Aspergillus nidulans
Joo-Yeon Lim, Seung-Hyun Jang, Hee-Moon Park
Current Genetics.2021; 67(4): 613. CrossRef
The putative C2H2 transcription factor RocA is a novel regulator of development and secondary metabolism in Aspergillus nidulans
Dong Chan Won, Yong Jin Kim, Da Hye Kim, Hee-Moon Park, Pil Jae Maeng
Journal of Microbiology.2020; 58(7): 574. CrossRef
Survival factor SvfA plays multiple roles in differentiation and is essential for completion of sexual development in Aspergillus nidulans
Joo-Yeon Lim, Eun-Hye Kang, Yun-Hee Park, Jun-Ho Kook, Hee-Moon Park
Scientific Reports.2020;[Epub] CrossRef
Fungal oxylipins direct programmed developmental switches in filamentous fungi
Mengyao Niu, Breanne N. Steffan, Gregory J. Fischer, Nandhitha Venkatesh, Nicholas L. Raffa, Molly A. Wettstein, Jin Woo Bok, Claudio Greco, Can Zhao, Erwin Berthier, Ernst Oliw, David Beebe, Michael Bromley, Nancy P. Keller
Nature Communications.2020;[Epub] CrossRef
The Cys2His2 zinc finger protein Zfp1 regulates sexual reproduction and virulence in Cryptococcus neoformans
Cheng-Li Fan, Lian-Tao Han, Su-Ting Jiang, An-Ni Chang, Ze-Yang Zhou, Tong-Bao Liu
Fungal Genetics and Biology.2019; 124: 59. CrossRef
Global gene expression changes reflecting pleiotropic effects of Irpex lacteus induced by low‐intensity electromagnetic field
Ling Sun, Xinyi Li, Haile Ma, Ronghai He, Prince O. Donkor
Bioelectromagnetics.2019; 40(2): 104. CrossRef
Transcription Factors Controlling Primary and Secondary Metabolism in Filamentous Fungi: The β-Lactam Paradigm
Carlos García-Estrada, Rebeca Domínguez-Santos, Katarina Kosalková, Juan-Francisco Martín
Fermentation.2018; 4(2): 47. CrossRef
Differential Control of Asexual Development and Sterigmatocystin Biosynthesis by a Novel Regulator in Aspergillus nidulans
Yong Jin Kim, Yeong Man Yu, Pil Jae Maeng
Scientific Reports.2017;[Epub] CrossRef
The signal peptide peptidase SppA is involved in sterol regulatory element‐binding protein cleavage and hypoxia adaptation in Aspergillus nidulans
Chinbayar Bat‐Ochir, Jun‐Yong Kwak, Sun‐Ki Koh, Mee‐Hyang Jeon, Dawoon Chung, Yin‐Won Lee, Suhn‐Kee Chae
Molecular Microbiology.2016; 100(4): 635. CrossRef
ZNF1 Encodes a Putative C2H2 Zinc-Finger Protein Essential for Appressorium Differentiation by the Rice Blast Fungus Magnaporthe oryzae
Xiaofeng Yue, Yawei Que, Lin Xu, Shuzhen Deng, Youliang Peng, Nicholas J. Talbot, Zhengyi Wang
Molecular Plant-Microbe Interactions®.2016; 29(1): 22. CrossRef

Effect of Zinc on Growth Performance, Gut Morphometry, and Cecal Microbial Community in Broilers Challenged with Salmonella enterica serovar Typhimurium: Yuxin Shao , Zhao Lei , Jianmin Yuan , Ying Yang , Yuming Guo , Bingkun Zhang; J. Microbiol. 2014;52(12):1002-1011. Published online November 29, 2014; DOI: https://doi.org/10.1007/s12275-014-4347-y

62 View
0 Download
65 Crossref

Abstract

To evaluate the effects of supplemental zinc on growth performance, gut morphometry, and the cecal microbial community in broilers challenged with Salmonella typhimurium, 180, 1-day-old male Cobb 500 broiler chicks were randomly assigned to 3 treatments with ten replicates for a 42 day experiment. The 3 treatments were: unchallenged, S. typhimurium- challenged, and S. typhimurium-challenged with 120 mg/kg of zinc supplementation in the diet. Salmonella infection caused a reduction in body-weight gain and feed intake, disrupted the intestinal structure by decreasing the villus-height/crypt-depth ratio of the ileum and increasing the apoptotic index of ileal epithelial cells. Moreover, the cecal microbial community was altered by Salmonella infection, as demonstrated by a reduced number of Lactobacillus and total bacteria. Dietary zinc supplementation improved growth performance by increasing the body-weight gain and feed intake in the challenged broilers. In addition, zinc repaired intestinal injury by reducing the apoptotic index of ileal epithelial cells, enhancing villus height and the villusheight/ crypt-depth ratio of the ileum, and the proliferation index of ileal epithelial cells. Finally, zinc regulated the cecal microbial community by increasing the number of total bacteria and beneficial Lactobacillus bacteria, and reducing the number of Salmonella. The results indicated that dietary zinc supplementation improved growth performance, intestinal morphology, and intestinal microbiota in S. typhimurium- challenged broilers.

Citations

Citations to this article as recorded by

Protective effects of sodium humate and its zinc and selenium chelate on the oxidative stress, inflammatory, and intestinal barrier damage of Salmonella Typhimurium-challenged broiler chickens
Yuying Fan, Wenzhu Zhou, Guili Li, Xuesong Liu, Peng Zhong, Kexin Liu, Yun Liu, Dong Wang
Poultry Science.2024; 103(5): 103541. CrossRef
Effects of Salmonella Outer Membrane Vesicles on Intestinal Microbiota and Intestinal Barrier Function
Meiying Luo, Suqian Li, Yang Yang, Junhang Sun, Yuman Su, Dechun Huang, Xin Feng, Huihua Zhang, Qien Qi
Foodborne Pathogens and Disease.2024; 21(4): 257. CrossRef
Two Doses of Zn Induced Different Microbiota Profiles and Dietary Zinc Supplementation Affects the Intestinal Microbial Profile, Intestinal Microarchitecture and Immune Response in Pigeons
Dongyan Zhang, Jing Li, Bo Zhang, Yuxin Shao, Zheng Wang
Animals.2024; 14(14): 2087. CrossRef
Use of Metallic Nanoparticles Against Eimeria—the Coccidiosis-Causing Agents: A Comprehensive Review
Sahar Mustafa, Rao Zahid Abbas, Zohaib Saeed, Narjes Baazaoui, Arslan Muhammad Ali Khan
Biological Trace Element Research.2024;[Epub] CrossRef
Pathogenicity of Multidrug-Resistant Salmonella typhimurium Isolated from Ducks
Yulin Xu, Zhitong Yu, Shaopeng Wu, Mengze Song, Lulu Cui, Shuhong Sun, Jiaqiang Wu
Microorganisms.2024; 12(7): 1359. CrossRef
Effect of Zinc Oxide Nanoparticles as Feed Additive on Blood Indices, Physiological, Immunological Responses, and Histological Changes in Broiler Chicks
Mahmoud H. Hatab, Aml M. M. Badran, Mahmoud A. Elaroussi, Eman Rashad, Adel M. Abu Taleb, Abdelmotaleb A. Elokil
Biological Trace Element Research.2024; 202(5): 2279. CrossRef
Levels of substitution of inorganic mineral to amino acids complexed minerals on old laying hens
Marcos J B Santos, Carlos B V Rabello, Jamille S S Wanderley, Maria C M M Ludke, Mércia R Barros, Fabiano S Costa, Clariana S Santos, Alba K Fireman
Scientific Reports.2024;[Epub] CrossRef
Effect of Organic, Nano, and Inorganic Zinc Sources on Growth Performance, Antioxidant Function, and Intestinal Health of Young Broilers
Shuxian Xie, Yipu Li, Yanrui Suo, Zheng Wang, Bo Zhang, Jing Li, Jianguo Huang, Yalei Wang, Chunjian Ma, Dongmei Lin, Tenghe Ma, Yuxin Shao
Biological Trace Element Research.2024;[Epub] CrossRef
The Role of Zinc in Developed Countries in Pediatric Patients: A 360-Degree View
Flavia Padoan, Elena Piccoli, Angelo Pietrobelli, Luis A. Moreno, Giorgio Piacentini, Luca Pecoraro
Biomolecules.2024; 14(6): 718. CrossRef
Zinc Oxide Nanoparticles Significant Role in Poultry and Novel Toxicological Mechanisms
Arjmand Fatima, Tean Zaheer, Kaushik Pal, Rao Zahid Abbas, Tayyaba Akhtar, Sultan Ali, Muhammad Shahid Mahmood
Biological Trace Element Research.2024; 202(1): 268. CrossRef
Dietary trace mineral pattern influences gut microbiota and intestinal health of broilers
Chuanlong Wang, Liangzhi Wang, Qingyi Chen, Xiaofeng Guo, Liyang Zhang, Xiudong Liao, Yanling Huang, Lin Lu, Xugang Luo
Journal of Animal Science.2023;[Epub] CrossRef
Effects of Major Families of Modulators on Performances and Gastrointestinal Microbiota of Poultry, Pigs and Ruminants: A Systematic Approach
Cyrielle Payen, Annaëlle Kerouanton, Jorge Novoa, Florencio Pazos, Carlos Benito, Martine Denis, Muriel Guyard, F. Javier Moreno, Marianne Chemaly
Microorganisms.2023; 11(6): 1464. CrossRef
The Impact of Phytase and Different Levels of Supplemental Amino Acid Complexed Minerals in Diets of Older Laying Hens
Waleska Medeiros-Ventura, Carlos Rabello, Marcos Santos, Mércia Barros, Rogério Silva Junior, Heraldo Oliveira, Fabiano Costa, Andresa Faria, Alba Fireman
Animals.2023; 13(23): 3709. CrossRef
The effects of dietary additives, vaccinations and processing aids as control measures for Salmonella spp. in chicken meat: A systematic review and meta-analysis
Adriana C. Castelo Taboada, Kathryn Glass, Dan Chateau, Anthony Pavic
Applied Food Research.2023; 3(1): 100254. CrossRef
Effects of Zinc Source and Level on the Intestinal Immunity of Xueshan Chickens under Heat Stress
Jian Jin, Mengxiao Xue, Yuchen Tang, Liangliang Zhang, Ping Hu, Yun Hu, Demin Cai, Xugang Luo, Ming-an Sun
Animals.2023; 13(19): 3025. CrossRef
Effect of Zinc Oxide Nanoparticles in Drinking Water on Growth Rate, Biochemical Parameters, and Intestinal Histology of Broilers
Arkan B. Mohammed, Oday K. Hamad, Thamer A. Khttab, Faheem Ahmed Khan
Advances in Agriculture.2023; 2023: 1. CrossRef
Multiple micronutrient deficiencies alter energy metabolism in host and gut microbiome in an early-life murine model
Paula T. Littlejohn, Haggai Bar-Yoseph, Karlie Edwards, Hong Li, Cynthia Y. Ramirez-Contreras, Ravi Holani, Avril Metcalfe-Roach, Yiyun M. Fan, Tom Min-Shih Yang, Nina Radisavljevic, Xiaoke Hu, James D. Johnson, B. Brett Finlay
Frontiers in Nutrition.2023;[Epub] CrossRef
Effects of dietary zinc oxide nanoparticles supplementation on broiler growth performance, zinc retention, liver health status, and gastrointestinal microbial load
Hidayat Mohd Yusof, Nor'Aini Abdul Rahman, Rosfarizan Mohamad, Uswatun Hasanah Zaidan, Muhammad Aiman Arshad, Anjas Asmara Samsudin
Journal of Trace Elements and Minerals.2023; 4: 100072. CrossRef
A bioinformatic analysis of zinc transporters in intestinal Lactobacillaceae
Uyen Huynh, Hazel N Nguyen, Brittany K Trinh, Joanna Elhaj, Melissa L Zastrow
Metallomics.2023;[Epub] CrossRef
Dietary Zinc Glycine Supplementation Improves Tibia Quality of Meat Ducks by Modulating the Intestinal Barrier and Bone Resorption
Leilei Wang, Ziyang Wang, Pengna Luo, Shiping Bai, Yu Chen, Wen Chen
Biological Trace Element Research.2023; 201(2): 888. CrossRef
Trace metal elements: a bridge between host and intestinal microorganisms
Yong Ma, Yanquan Fei, Sujuan Ding, Hongmei Jiang, Jun Fang, Gang Liu
Science China Life Sciences.2023; 66(9): 1976. CrossRef
Regulation of Inorganic Zinc Supplementation on Intestinal Absorption, Metabolism, and Muscle Development in Broilers Fed Low-Protein Diets
Ruihong Sun, Changhai Zhou, Yougang Jia, Yumei Li, Yuntong He, Haoyu Che, Yonghong Zhang, Jing Zhang, Dongqiao Peng
Agriculture.2023; 13(12): 2239. CrossRef
Gut microbiome modulation: Ancillary effects of inorganic nanoparticles on gut microflora
SEHRISH ABBAS, BUSHRA UZAIR, MAISRA AZHAR BUTT, FARID MENAA, BARKAT A. KHAN
BIOCELL.2023; 47(2): 245. CrossRef
Pioneer colonizers: Bacteria that alter the chicken intestinal morphology and development of the microbiota
Margie D. Lee, Adriana A. Pedroso, Brett Lumpkins, Youngjae Cho, John J. Maurer
Frontiers in Physiology.2023;[Epub] CrossRef
Metallobiology of Lactobacillaceae in the gut microbiome
Uyen Huynh, Melissa L. Zastrow
Journal of Inorganic Biochemistry.2023; 238: 112023. CrossRef
Respuesta histomorfométrica de la mucosa del intestino delgado en cuyes (Cavia porcellus) de engorde desafiados con Salmonella enterica var. Typhimurium
Sandra Gracia Bezada-Quintana, Fernando Demetrio Carcelén-Cáceres, Sofía López-Guerra, Jorge Ernesto Guevara-Vásquez
Revista Científica de la Facultad de Ciencias Veterinarias.2023; XXXIII(1): 1. CrossRef
Differential Effects of Transition Metals on Growth and Metal Uptake for Two DistinctLactobacillusSpecies
Uyen Huynh, Muxin Qiao, John King, Brittany Trinh, Juventino Valdez, Marium Haq, Melissa L. Zastrow, Amanda G. Oglesby
Microbiology Spectrum.2022;[Epub] CrossRef
Effects of Dietary Nutrients on Fatty Liver Disease Associated With Metabolic Dysfunction (MAFLD): Based on the Intestinal-Hepatic Axis
Nan Yao, Yixue Yang, Xiaotong Li, Yuxiang Wang, Ruirui Guo, Xuhan Wang, Jing Li, Zechun Xie, Bo Li, Weiwei Cui
Frontiers in Nutrition.2022;[Epub] CrossRef
Influence of Dietary Biosynthesized Zinc Oxide Nanoparticles on Broiler Zinc Uptake, Bone Quality, and Antioxidative Status
Hidayat Mohd Yusof, Nor’Aini Abdul Rahman, Rosfarizan Mohamad, Uswatun Hasanah Zaidan, Anjas Asmara Samsudin
Animals.2022; 13(1): 115. CrossRef
Effect of zinc and phytase supplementation on performance, immune response, digestibility and intestinal features in broilers fed a wheat-soybean meal diet
Heydar Zarghi, Abolghasem Golian, Ahmad Hassanabadi, Farhad Khaligh
Italian Journal of Animal Science.2022; 21(1): 430. CrossRef
A perspective review on the effect of different forms of zinc on poultry production of poultry with special reference to the hazardous effects of misuse
Wafaa A. Abd El-Ghany
CABI Reviews.2022;[Epub] CrossRef
Functional Gastrointestinal Disorders with Psychiatric Symptoms: Involvement of the Microbiome–Gut–Brain Axis in the Pathophysiology and Case Management
Cristina Gabriela Șchiopu, Cristinel Ștefănescu, Alexandra Boloș, Smaranda Diaconescu, Georgiana-Emmanuela Gilca-Blanariu, Gabriela Ștefănescu
Microorganisms.2022; 10(11): 2199. CrossRef
Effect of Dietary Zinc Methionine Supplementation on Growth Performance, Immune Function and Intestinal Health of Cherry Valley Ducks Challenged With Avian Pathogenic Escherichia coli
Yaqi Chang, Jia Mei, Ting Yang, Zhenyu Zhang, Guangmang Liu, Hua Zhao, Xiaoling Chen, Gang Tian, Jingyi Cai, Bing Wu, Fali Wu, Gang Jia
Frontiers in Microbiology.2022;[Epub] CrossRef
Protective Effects of Zinc on Salmonella Invasion, Intestinal Morphology and Immune Response of Young Pigeons Infected with Salmonella enterica Serovar Typhimurium
Zheng Wang, Xing Li, Shaohua Du, Xiaoshan Sun, Jianguo Huang, Yuxin Shao
Biological Trace Element Research.2022; 200(11): 4817. CrossRef
Thymol nanoemulsion promoted broiler chicken’s growth, gastrointestinal barrier and bacterial community and conferred protection against Salmonella Typhimurium
Doaa Ibrahim, Ahmed Abdelfattah-Hassan, M. Badawi, Tamer Ahmed Ismail, Mahmoud M. Bendary, Adel M. Abdelaziz, Rasha A. Mosbah, Dalia Ibrahim Mohamed, Ahmed H. Arisha, Marwa I. Abd El-Hamid
Scientific Reports.2021;[Epub] CrossRef
Zinc hydroxychloride supplementation improves tibia bone development and intestinal health of broiler chickens
H.T.T. Nguyen, N. Morgan, J.R. Roberts, S.-B. Wu, R.A. Swick, M. Toghyani
Poultry Science.2021; 100(8): 101254. CrossRef
Modulation of Gut Microbiota for the Prevention and Treatment of COVID-19
Jiezhong Chen, Luis Vitetta
Journal of Clinical Medicine.2021; 10(13): 2903. CrossRef
Do Only Calcium and Vitamin D Matter? Micronutrients in the Diet of Inflammatory Bowel Diseases Patients and the Risk of Osteoporosis
Alicja Ewa Ratajczak, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak
Nutrients.2021; 13(2): 525. CrossRef
Effect of zinc supplementation on growth performance, intestinal development, and intestinal barrier function in Pekin ducks with lipopolysaccharide challenge
Yueqin Xie, Min Wen, Hua Zhao, Guangmang Liu, Xiaoling Chen, Gang Tian, Jingyi Cai, Gang Jia
Poultry Science.2021; 100(12): 101462. CrossRef
Gut Microbiota as a Mediator of Essential and Toxic Effects of Zinc in the Intestines and Other Tissues
Anatoly V. Skalny, Michael Aschner, Xin Gen Lei, Viktor A. Gritsenko, Abel Santamaria, Svetlana I. Alekseenko, Nagaraja Tejo Prakash, Jung-Su Chang, Elena A. Sizova, Jane C. J. Chao, Jan Aaseth, Alexey A. Tinkov
International Journal of Molecular Sciences.2021; 22(23): 13074. CrossRef
Regulatory effects of transition metals supplementation/deficiency on the gut microbiota
Cheng-Yu Li, Xin-Yu Li, Liang Shen, Hong-Fang Ji
Applied Microbiology and Biotechnology.2021; 105(3): 1007. CrossRef
Antibacterial Potential of Biosynthesized Zinc Oxide Nanoparticles against Poultry-Associated Foodborne Pathogens: An In Vitro Study
Hidayat Mohd Yusof, Nor’Aini Abdul Rahman, Rosfarizan Mohamad, Uswatun Hasanah Zaidan, Anjas Asmara Samsudin
Animals.2021; 11(7): 2093. CrossRef
Evaluation of potentiated zinc oxide as a source of zinc in broiler chickens
Xin Jian Lei, Zhuang Zhuang Liu, Qi Lin Wang, Dang Dang Wang, Meng Ya Wang, Jun Hu Yao, In Ho Kim
Animal Feed Science and Technology.2021; 281: 115097. CrossRef
Nano-sized Zinc in Broiler Chickens: Effects on Growth Performance, Zinc Concentration in Organs, and Intestinal Morphology
Alip Kumar, Abdolreza Hosseindoust, MinJu Kim, KwangYeol Kim, YoHan Choi, SeokHee Lee, SongYi Lee, JunHyung Lee, HyunJong Cho, Wei Soo Kang, ByungJo Chae
The Journal of Poultry Science.2021; 58(1): 21. CrossRef
Macrophage-Mediated Defensive Mechanisms Involving Zinc Homeostasis in Bacterial Infection
Pinanong Na-Phatthalung, Junxia Min, Fudi Wang
Infectious Microbes and Diseases.2021; 3(4): 175. CrossRef
Influence of Dietary Zinc, Copper, and Manganese on the Intestinal Health of Broilers Under Eimeria Challenge
Cristiano Bortoluzzi, Bruno Serpa Vieira, Todd Jay Applegate
Frontiers in Veterinary Science.2020;[Epub] CrossRef
Effects of Glutamine on the Mucosal Structure and Immune Cells in the Intestines of Broiler Chickens Challenged with Salmonella Enteritidis
Z Liu, Q Wu, C Jiao, B Cheng, D Zhu, Y Ma, Y Li, W Li
Brazilian Journal of Poultry Science.2020;[Epub] CrossRef
The relationship among gut microbiota, short-chain fatty acids, and intestinal morphology of growing and healthy broilers
Xiudong Liao, Yuxin Shao, Guangming Sun, Yunfeng Yang, Liyang Zhang, Yanli Guo, Xugang Luo, Lin Lu
Poultry Science.2020; 99(11): 5883. CrossRef
Dietary zinc source impacts intestinal morphology and oxidative stress in young broilers
Annatachja De Grande, Saskia Leleu, Evelyne Delezie, Christof Rapp, Stefaan De Smet, Evy Goossens, Freddy Haesebrouck, Filip Van Immerseel, Richard Ducatelle
Poultry Science.2020; 99(1): 441. CrossRef
Role of Dietary Nutrients in the Modulation of Gut Microbiota: A Narrative Review
Qi Yang, Qi Liang, Biju Balakrishnan, Damien P Belobrajdic, Qian-Jin Feng, Wei Zhang
Nutrients.2020; 12(2): 381. CrossRef
Zinc, manganese and copper amino acid complexed in laying hens’ diets affect performance, blood parameters and reproductive organs development
Camilla Gomes Pereira, Carlos Boa-Viagem Rabello, Mércia Rodrigues Barros, Helena Emilia C. C. C. Manso, Marcos Jose Batista dos Santos, Andresa G. Faria, Heraldo Bezerra de Oliveira, Waleska Rocha Leite Medeiros-Ventura, Rogerio Ventura Silva Júnior, Cle
PLOS ONE.2020; 15(11): e0239229. CrossRef
Reduction of Salmonella Typhimurium Cecal Colonisation and Improvement of Intestinal Health in Broilers Supplemented with Fermented Defatted ‘Alperujo’, an Olive Oil By-Product
Agustín Rebollada-Merino, María Ugarte-Ruiz, Marta Hernández, Pedro Miguela-Villoldo, David Abad, David Rodríguez-Lázaro, Lucía de Juan, Lucas Domínguez, Antonio Rodríguez-Bertos
Animals.2020; 10(10): 1931. CrossRef
Efficacy of Trace Mineral-Amino Acid Complexes in a Necrotic Enteritis Challenge Model
Greg F. Mathis, Charles L. Hofacre, Brett S. Lumpkins, Matthew K. Jones, Marco A. Rebollo, Duarte Neves, John A. Smith
Avian Diseases.2020;[Epub] CrossRef
Bioavailability of Methionine-Coated Zinc Nanoparticles as a Dietary Supplement Leads to Improved Performance and Bone Strength in Broiler Chicken Production
Ashraf Alkhtib, Dawn Scholey, Nicholas Carter, Gareth W.V. Cave, Belal I. Hanafy, Siani R.J. Kempster, Subbareddy Mekapothula, Eve T. Roxborough, Emily J. Burton
Animals.2020; 10(9): 1482. CrossRef
Zinc source modulates intestinal inflammation and intestinal integrity of broiler chickens challenged with coccidia and Clostridium perfringens
C. Bortoluzzi, B. Lumpkins, G.F. Mathis, M. França, W.D. King, D.E. Graugnard, K.A. Dawson, T.J. Applegate
Poultry Science.2019; 98(5): 2211. CrossRef
The Alterations of Copper and Zinc Homeostasis in Acute Appendicitis and the Clinical Significance
Wenhao Lin, Wei Han, Ke Wen, Sunhua Huang, Yao Tang, Zhexuan Lin, Ming Han
Biological Trace Element Research.2019; 192(2): 116. CrossRef
Gut microbiota and inflammation in chronic kidney disease and their roles in the development of cardiovascular disease
Emine M. Onal, Baris Afsar, Adrian Covic, Nosratola D. Vaziri, Mehmet Kanbay
Hypertension Research.2019; 42(2): 123. CrossRef
Can dietary zinc diminish the impact of necrotic enteritis on growth performance of broiler chickens by modulating the intestinal immune-system and microbiota?
C Bortoluzzi, B.S. Vieira, B Lumpkins, G.F. Mathis, W.D. King, D Graugnard, K.A. Dawson, T.J. Applegate
Poultry Science.2019; 98(8): 3181. CrossRef
Effect of Zinc Supplementation on Growth Performance, Intestinal Development, and Intestinal Barrier-Related Gene Expression in Pekin Ducks
Min Wen, Hua Zhao, Guangmang Liu, Xiaoling Chen, Bing Wu, Gang Tian, Jingyi Cai, Gang Jia
Biological Trace Element Research.2018; 183(2): 351. CrossRef
Intestinal microbiome of broiler chickens after use of nanoparticles and metal salts
Еlena Yausheva, Sergey Miroshnikov, Еlena Sizova
Environmental Science and Pollution Research.2018; 25(18): 18109. CrossRef
Source of supplemental dietary copper, zinc, and manganese affects fecal microbial relative abundance in lactating dairy cows
M.J. Faulkner, B.A. Wenner, L.M. Solden, W.P. Weiss
Journal of Dairy Science.2017; 100(2): 1037. CrossRef
Zinc Oxide Nanoparticles Influence Microflora in Ileal Digesta and Correlate Well with Blood Metabolites
Yanni Feng, Lingjiang Min, Weidong Zhang, Jing Liu, Zhumei Hou, Meiqiang Chu, Lan Li, Wei Shen, Yong Zhao, Hongfu Zhang
Frontiers in Microbiology.2017;[Epub] CrossRef
Inorganic or organic zinc and MUC-2, IgA, IL-17, TGF-β4 gene expression and sIgA secretion in broiler chickens
Martin Levkut, Eva Husáková, Katarina Bobíková, Viera Karaffová, Mikuláš Levkutová, Okasana Ivanišinová, Ľubomira Grešáková, Klaudia Čobanová, Katarína Reiterová, Mikuláš Levkut
Food and Agricultural Immunology.2017; 28(5): 801. CrossRef
Zinc enhances intestinal epithelial barrier function through the PI3K/AKT/mTOR signaling pathway in Caco-2 cells
Yuxin Shao, Patricia G. Wolf, Shuangshuang Guo, Yuming Guo, H. Rex Gaskins, Bingkun Zhang
The Journal of Nutritional Biochemistry.2017; 43: 18. CrossRef
Effect of Zinc on Appetite Regulatory Peptides in the Hypothalamus of Salmonella-Challenged Broiler Chickens
Xiyi Hu, Ardashir Sheikhahmadi, Xianlei Li, Yufeng Wang, Hongchao Jiao, Hai Lin, Bingkun Zhang, Zhigang Song
Biological Trace Element Research.2016; 172(1): 228. CrossRef

Potentiation of Bacterial Killing Activity of Zinc Chloride by Pyrrolidine Dithiocarbamate: Eun-Kyoung Choi , Hye-Hyang Lee , Mi-Sun Kang , Byung-Gook Kim , Hoi-Soon Lim , Seon-Mi Kim , In-Chol Kang; J. Microbiol. 2010;48(1):40-43. Published online March 11, 2010; DOI: https://doi.org/10.1007/s12275-009-0049-2

43 View
0 Download
24 Scopus

Abstract: Zinc has antimicrobial activity and zinc salts including zinc chloride (ZnCl2) have been used for the control of oral malodor. In this study, we hypothesized that pyrrolidine dithiocarbamate (PDTC), a zinc ionophore, may enhance antimicrobial efficacy of ZnCl2. The bactericidal effectiveness of ZnCl2 alone (0.5-8 mM) or in combination with PDTC (1 or 10 μM) was evaluated by in vitro short (1 h) time-killing assays against Fusobacterium nucleatum and Porphyromonas gingivalis. Only a slight viability decrease was observed with ZnCl2 or PDTC alone after 1-h incubation. By contrast, combination of ZnCl2 and PDTC could achieve a more than 100-fold viability reduction compared with ZnCl2 or PDTC alone in F. nucleatum and P. gingivalis. Therefore, PDTC greatly enhanced the bactericidal activity of ZnCl2 against the oral malodor-producing bacteria. These results suggest that use of PDTC may be useful for enhancing bactericidal activity of antimalodor regimens of zinc salts.

Bacterial Diversity at Different Depths in Lead-Zinc Mine Tailings as Revealed by 16S rRNA Gene Libraries: Han-Bo Zhang , Wen Shi , Ming-Xia Yang , Tao Sha , Zhi-Wei Zhao; J. Microbiol. 2007;45(6):479-484.; DOI: https://doi.org/2648 [pii]

41 View
0 Download

Abstract: Bacterial communities at 10 cm, 100 cm, and 200 cm depths in a 100-year-old lead-zinc tailing heap were evaluated by constructing 16S rRNA gene libraries. In total, 98 operational taxonomic units (OTUs) were identified from 193 clones at a 3% sequence difference level. The OTU number and species richness decreased with the depth. Species composition was significantly different between the three libraries. Fifty-seven percent of the examined clones were Acidobacteria and 27% belonged to Proteobacteria. Other sequences included Chloroflexi, Firmicutes, Chlamydiae, Actinobacteria, Gemmatimonadetes, Nitrospira, and three unclassified OTUs. Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Firmicutes, and Actinobacteria were mainly distributed in the rhizosphere of naturally colonizing plants; however, Deltaproteobacteria, Acidobacteria, and Chloroflexi tended to inhabit the deeper tailings (below the 100 cm-depth).

Effect of Zinc and Calcium on the Intracelularly uptake of Cadimium and growth of Escherichia coli: Hong, Hyo Bong , Brown, Lewis R. , Kim, Jong Kyu; J. Microbiol. 1995;33(4):302-306.

44 View
0 Download

Abstract: E. coli was tested for their ability to uptake cadmium intracellularly, and the effect of zinc and calcium on cadmium toxicity to E. coli was observed. In addition, the effect of zinc and calcium on the uptake of cadimium was also studied. This study showed that living E. coli cells took up more cadmium than the dead cells. E. coli in the log phase uptake cadimiumm more actively than E. coli in the stationary phase. These results suggested that there may be metabolic reactions or compounds which encourage the uptake of cadimium. This study also showed that cadimium was sequestered by cell components of which molecular weight is about 30,000. Adding of zinc and calcium chloride reduced cadmium toxicity in E. coli and encouraged intracellular uptake by E coli. However adding of heavy metal solutions helped the microorganisms to adsorb more cadmium. Extremely high or low concentrations of zinc, however, did not affect cell viability.

First
Prev
Page of 1
Next
Last

Search