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- Protective and pathogenic role of humoral responses in COVID-19
- Uni Park , Nam-Hyuk Cho
- J. Microbiol. 2022;60(3):268-275. Published online March 2, 2022
- DOI: https://doi.org/10.1007/s12275-022-2037-8
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- 5 Web of Science
- 3 Crossref
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Abstract
- Since the advent of SARS-CoV-2 in Dec. 2019, the global endeavor to identify the pathogenic mechanism of COVID-19 has been ongoing. Although humoral immunity including neutralizing activity play an important role in protection from the viral pathogen, dysregulated antibody responses may be associated with the pathogenic progression of COVID-19, especially in high-risk individuals. In addition, SARS-CoV-2 spike-specific antibodies acquired by prior infection or vaccination act as immune pressure, driving continuous population turnover by selecting for antibody-escaping mutations. Here, we review accumulating knowledge on the potential role of humoral immune responses in COVID-19, primarily focusing on their beneficial and pathogenic properties. Understanding the multifaceted regulatory mechanisms of humoral responses during SARS-CoV-2 infection can help us to develop more effective therapeutics, as well as protective measures against the ongoing pandemic.
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Citations
Citations to this article as recorded by
- Rise in broadly cross-reactive adaptive immunity against human β-coronaviruses in MERS-recovered patients during the COVID-19 pandemic
So-Hee Kim, Yuri Kim, Sangeun Jeon, Uni Park, Ju-Il Kang, Kyeongseok Jeon, Hye-Ran Kim, Songhyeok Oh, Ji-Young Rhee, Jae-Phil Choi, Wan Beom Park, Sang Won Park, Jeong-Sun Yang, Joo-Yeon Lee, Jihye Kang, Hyoung-Shik Shin, Yeonjae Kim, Seungtaek Kim, Yeon-
Science Advances.2024;[Epub] CrossRef - Distinctive Combinations of RBD Mutations Contribute to Antibody Evasion in the Case of the SARS-CoV-2 Beta Variant
Tae-Hun Kim, Sojung Bae, Sunggeun Goo, Jinjong Myoung
Journal of Microbiology and Biotechnology.2023; 33(12): 1587. CrossRef - Two years of COVID-19 pandemic: where are we now?
Jinjong Myoung
Journal of Microbiology.2022; 60(3): 235. CrossRef
- Rise in broadly cross-reactive adaptive immunity against human β-coronaviruses in MERS-recovered patients during the COVID-19 pandemic
Research Support, Non-U.S. Gov't
- Two Rhizobacterial Strains, Individually and in Interactions with Rhizobium sp., Enhance Fusarial Wilt Control, Growth, and Yield in Pigeon Pea
- Swarnalee Dutta , Pranjal Morang , Nishanth Kumar S , B.S. Dileep Kumar
- J. Microbiol. 2014;52(9):778-784. Published online September 2, 2014
- DOI: https://doi.org/10.1007/s12275-014-3496-3
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- 7 Crossref
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Abstract
- A Pseudomonas aeruginosa strain, RRLJ 04, and a Bacillus cereus strain, BS 03, were tested both individually and in combination with a Rhizobium strain, RH 2, for their ability to enhance plant growth and nodulation in pigeon pea (Cajanus cajan L.) under gnotobiotic, greenhouse and field conditions. Both of the rhizobacterial strains exhibited a positive effect on growth in terms of shoot height, root length, fresh and dry weight, nodulation and yield over the non-treated control. Co-inoculation of seeds with these strains and Rhizobium RH 2 also reduced the number of wilted plants, when grown in soil infested with Fusarium udum. Gnotobiotic studies confirmed that the suppression of wilt disease was due to the presence of the respective PGPR strains. Seed bacterization with drug-marked mutants of RRLJ 04 and BS 03 confirmed their ability to colonize and multiply along the roots. The results suggest that co-inoculation of these strains with Rhizobium strain RH 2 can be further exploited for enhanced growth, nodulation and yield in addition to control of fusarial wilt in pigeon pea.
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Citations
Citations to this article as recorded by- Population and diversity of pigeonpea rhizobia from the Indo-Gangetic plains of India
Shiv Charan Kumar, Prachi Singh, Murugan Kumar, Mahendra Vikram Singh Rajawat, Waquar Akhter Ansari, Desiraju Lakshmi Narsimha Rao, Anil Kumar Saxena
Symbiosis.2023; 90(2): 213. CrossRef - Coinoculation impact on plant growth promotion: a review and meta-analysis on coinoculation of rhizobia and plant growth-promoting bacilli in grain legumes
Glaciela Kaschuk, André Carlos Auler, Crislaine Emidio Vieira, Felix Dapore Dakora, Sanjay K. Jaiswal, Sonia Purin da Cruz
Brazilian Journal of Microbiology.2022; 53(4): 2027. CrossRef - An improved high-throughput method for assessing the impact of bioformulation on plant parameters: Case study with pigeonpea seeds
Sakshi Tewari, Shilpi Sharma
Physiological and Molecular Plant Pathology.2021; 115: 101657. CrossRef - Rhizobial-metabolite based biocontrol of fusarium wilt in pigeon pea
Sakshi Tewari, Shilpi Sharma
Microbial Pathogenesis.2020; 147: 104278. CrossRef - Tea root brown-rot fungus disease reduction and yield recovery with rhizobacteria inoculation in both nursery and field trials
P. Morang, S.P. Devi, D.K. Jha, B.K. Dutta, B.S. Dileep Kumar
Rhizosphere.2018; 6: 89. CrossRef - Lettuce and rhizosphere microbiome responses to growth promotingPseudomonasspecies under field conditions
Matheus A. P. Cipriano, Manoeli Lupatini, Lucilene Lopes-Santos, Márcio J. da Silva, Luiz F. W. Roesch, Suzete A. L. Destéfano, Sueli S. Freitas, Eiko E. Kuramae, Angela Sessitsch
FEMS Microbiology Ecology.2016; 92(12): fiw197. CrossRef - Bradyrhizobium yuanmingense related strains form nitrogen-fixing symbiosis with Cajanus cajan L. in Dominican Republic and are efficient biofertilizers to replace N fertilization
Juan Araujo, César-Antonio Díaz-Alcántara, Encarna Velázquez, Beatriz Urbano, Fernando González-Andrés
Scientia Horticulturae.2015; 192: 421. CrossRef
- Population and diversity of pigeonpea rhizobia from the Indo-Gangetic plains of India
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