H5 influenza viruses have caused much alarm globally due
to their high pathogenic potential. As yet we have not seen
sustained spread of the virus amongst humans despite a high
prevalence of the virus in avian populations. Nevertheless,
isolated human cases of infection have demonstrated high
mortality and there are substantial efforts being taken to
monitor the evolution of the virus and to undertake preparedness
activities. Here we review and discuss the evolution of
the A/goose/Guangdong/1/96 (H5N1) virus with emphasis
on recent events.
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