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Superinfection Exclusion Reveals Heteroimmunity between Pseudomonas aeruginosa Temperate Phages
In-Young Chung , Hee-Won Bae , Hye-Jung Jang , Bi-o Kim , You-Hee Cho
J. Microbiol. 2014;52(6):515-520.   Published online May 29, 2014
DOI: https://doi.org/10.1007/s12275-014-4012-5
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AbstractAbstract
Temperate siphophages (MP29, MP42, and MP48) were isolated from the culture supernatant of clinical Pseudomonas aeruginosa isolates. The complete nucleotide sequences and annotation of the phage genomes revealed the overall synteny to the known temperate P. aeruginosa phages such as MP22, D3112, and DMS3. Genome-level sequence analysis showed the conservation of both ends of the linear genome and the divergence at the previously identified dissimilarity regions (R1 to R9). Protein sequence alignment of the c repressor (ORF1) of each phage enabled us to divide the six phages into two groups: D3112 group (D3112, MP29, MP42, and MP48) and MP22 group (MP22 and DMS3). Superinfection exclusion was observed between the phages belonging to the same group, which was mediated by the specific interaction between the c repressor and the cognate operator. Based on these, we suggest that the temperate siphophages prevalent in the clinical strains of P. aeruginosa represent at least two distinct heteroimmunity groups.

Citations

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Review
REVIEW] When a Virus is not a Parasite: The Beneficial Effects of Prophages
Joseph Bondy-Denomy , Alan R. Davidson
J. Microbiol. 2014;52(3):235-242.   Published online March 1, 2014
DOI: https://doi.org/10.1007/s12275-014-4083-3
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  • 120 Crossref
AbstractAbstract
Most organisms on the planet have viruses that infect them. Viral infection may lead to cell death, or to a symbiotic relationship where the genomes of both virus and host replicate together. In the symbiotic state, both virus and cell potentially experience increased fitness as a result of the other. The viruses that infect bacteria, called bacteriophages (or phages), well exemplify the symbiotic relationships that can develop between viruses and their host. In this review, we will discuss the many ways that prophages, which are phage genomes integrated into the genomes of their hosts, influence bacterial behavior and virulence.

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