Journal of Microbiology

Journal Article

Burkholderia cepacia Complex Infection in a Cohort of Italian Patients with Cystic Fibrosis: Antonietta Lambiase , Valeria Raia , Stefania Stefani , Angela Sepe , Pasqualina Ferri , Paolo Buonpensiero , Fabio Rossano , Mariassunta Del Pezzo; J. Microbiol. 2007;45(3):275-279.; DOI: https://doi.org/2530 [pii]

Abstract: The aims of this study were to detect Burkholderia cepacia complex (Bcc) strains in a cohort of Cystic Fibrosis patients (n=276) and to characterize Bcc isolates by molecular techniques. The results showed that 11.23% of patients were infected by Bcc. Burkholderia cenocepacia lineage III-A was the most prevalent species (64.3%) and, of these, 10% was cblA positive and 50% esmR positive. Less than half of the strains were sensitive to ceftazidime, meropenem, piperacillin tazobactam, and trimethoprim-sulfamethoxazole. About half of the strains (41%) had homogeneous profiles, suggesting cross-transmission. The infection by B. cenocepacia was associated to a high rate of mortality (p=0.01).

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