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- Coronavirus enzyme inhibitors-experimentally proven natural compounds from plants
- Junsoo Park , Rackhyun Park , Minsu Jang , Yea-In Park , Yeonjeong Park
- J. Microbiol. 2022;60(3):347-354. Published online January 28, 2022
- DOI: https://doi.org/10.1007/s12275-022-1499-z
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- 7 Web of Science
- 7 Crossref
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Abstract
- Coronavirus disease (COVID-19) can cause critical conditions that require efficient therapeutics. Several medicines are derived from plants, and researchers are seeking natural compounds to ameliorate the symptoms of COVID-19. Viral enzymes are popular targets of antiviral medicines; the genome of coronaviruses encodes several enzymes, including RNAdependent RNA polymerase and viral proteases. Various screening systems have been developed to identify potential inhibitors. In this review, we describe the natural compounds that have been shown to exert inhibitory effects on coronavirus enzymes. Although computer-aided molecular structural studies have predicted several antiviral compound candidates, the current review focuses on experimentally proven natural compounds.
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Citations
Citations to this article as recorded by
- Eupatin, a Flavonoid, Inhibits Coronavirus 3CL Protease and Replication
Yea-In Park, Jang Hoon Kim, Siyun Lee, Ik Soo Lee, Junsoo Park
International Journal of Molecular Sciences.2023; 24(11): 9211. CrossRef - Structural Insights into Plasticity and Discovery of Flavonoid Allosteric Inhibitors of Flavivirus NS2B–NS3 Protease
Marielena Vogel Saivish, Gabriela de Lima Menezes, Vivaldo Gomes da Costa, Liliane Nebo, Gislaine Celestino Dutra da Silva, Carolina Colombelli Pacca, Rafael Elias Marques, Maurício Lacerda Nogueira, Roosevelt Alves Da Silva
Biophysica.2023; 3(1): 71. CrossRef - Plants as Biofactories for Therapeutic Proteins and Antiviral Compounds to Combat COVID-19
Corbin England, Jonathan TrejoMartinez, Paula PerezSanchez, Uddhab Karki, Jianfeng Xu
Life.2023; 13(3): 617. CrossRef - Computational investigation of natural compounds as potential main protease (Mpro) inhibitors for SARS-CoV-2 virus
Chirag N. Patel, Siddhi P. Jani, Sivakumar Prasanth Kumar, Krunal M. Modi, Yogesh Kumar
Computers in Biology and Medicine.2022; 151: 106318. CrossRef - Two years of COVID-19 pandemic: where are we now?
Jinjong Myoung
Journal of Microbiology.2022; 60(3): 235. CrossRef - Identification of SARS-CoV-2 Main Protease Inhibitors from a Library of Minor Cannabinoids by Biochemical Inhibition Assay and Surface Plasmon Resonance Characterized Binding Affinity
Chang Liu, Tess Puopolo, Huifang Li, Ang Cai, Navindra P. Seeram, Hang Ma
Molecules.2022; 27(18): 6127. CrossRef - Computational Approaches in the Discovery and Development of Therapeutic
and Prophylactic Agents for Viral Diseases
Anand Gaurav, Neetu Agrawal, Mayasah Al-Nema, Vertika Gautam
Current Topics in Medicinal Chemistry.2022; 22(26): 2190. CrossRef
- Eupatin, a Flavonoid, Inhibits Coronavirus 3CL Protease and Replication
Research Support, Non-U.S. Gov't
- Clarithromycin Resistance Prevalence and Icea Gene Status in Helicobacter Pylori Clinical Isolates in Turkish Patients with Duodenal Ulcer and Functional Dyspepsia
- Peren H. Baglan , Gulendam Bozdayi , Muhip Ozkan , Kamruddin Ahmed , A. Mithat Bozdayi , Ali Ozden
- J. Microbiol. 2006;44(4):409-416.
- DOI: https://doi.org/2412 [pii]
- 43 View
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Abstract
- Clarithromycin resistance in Helicobacter pylori is a principal cause of failure of eradication therapies, and its prevalence varies geographically. The IceA gene is a virulence factor associated with clinical outcomes. The objective of this study was to determine the current state of clarithromycin resistance prevalence, and to investigate the role of iceA genotypes in 87 Turkish adult patients (65 with functional dyspepsia and 22 with duodenal ulcer). A2143G and A2144G point mutations were tested by PCR-RFLP for clarithromycin resistance. Among the patients in the study, 28 patients were tested by agar dilution as well. Allelic variants of the iceA gene were identified by PCR. A total of 24 (27.6%) strains evidenced one of the mutations, either A2143G or A2144G. IceA1 was found to be positive in 28 of the strains (32.2%), iceA2 was positive in 12 (13.8%) and, both iceA1 and iceA2 were positive in 22 (25.3%) strains. In conclusion, we discovered no relationships between iceA genotypes and functional dyspepsia or duodenal ulcer, nor between clarithromycin resistance and iceA genotypes. Clarithromycin resistance appears to be more prevalent in Turkish patients.
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