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- Effect of amikacin on cell wall glycopeptidolipid synthesis in Mycobacterium abscessus
- So-Young Lee , Hee-Youn Kim , Byoung-Jun Kim , Hong Kim , Seung-hyeok Seok , Bum-Joon Kim , Yoon-Hoh Kook
- J. Microbiol. 2017;55(8):640-647. Published online July 28, 2017
- DOI: https://doi.org/10.1007/s12275-017-6503-7
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- 7 Crossref
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Abstract
- Cultivation of the smooth colony Mycobacterium abscessus at the sub-minimum inhibitory concentration (MIC) of amikacin changed its growth pattern including its colony morphology (smooth to rough) and cell arrangement (dispersed to cord formation). In addition, reduced sliding motility and biofilm formation were observed. The amount of glycogpetidolipid (GPL) and mRNA expression of key genes involved in GPL synthesis were decreased in the amikacin-treated M. abscessus strain. An in vitro infection assay revealed that the amikacin-treated smooth M. abscessus strain induced more pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) than that of the smooth strain in murine macrophage cells. These results suggest that long-term exposure to a low concentration of amikacin causes a physical change in the cell wall which may increase its virulence.
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Citations
Citations to this article as recorded by
- Drugs for treating infections caused by non-tubercular mycobacteria: a narrative review from the study group on mycobacteria of the Italian Society of Infectious Diseases and Tropical Medicine
A. Calcagno, N. Coppola, L. Sarmati, M. Tadolini, R. Parrella, A. Matteelli, N. Riccardi, M. Trezzi, A. Di Biagio, V. Pirriatore, A. Russo, G. Gualano, E. Pontali, L. Surace, E. Falbo, J. Mencarini, F. Palmieri, A. Gori, M. Schiuma, G. Lapadula, D. Golett
Infection.2024; 52(3): 737. CrossRef - Moles of Molecules against Mycobacterium abscessus: A Review of Current Research
Mario Cocorullo, Christian Bettoni, Sara Foiadelli, Giovanni Stelitano
Future Pharmacology.2023; 3(3): 637. CrossRef - Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2017–2018
David J. Harvey
Mass Spectrometry Reviews.2023; 42(1): 227. CrossRef - The role of amikacin in the treatment of nontuberculous mycobacterial disease
Jelmer Raaijmakers, Jodie Anne Schildkraut, Wouter Hoefsloot, Jakko van Ingen
Expert Opinion on Pharmacotherapy.2021; 22(15): 1961. CrossRef - Integrated Quantitative Proteomics and Metabolome Profiling Reveal MSMEG_6171 Overexpression Perturbing Lipid Metabolism of Mycobacterium smegmatis Leading to Increased Vancomycin Resistance
Zhuhua Wu, Wenjing Wei, Ying Zhou, Huixin Guo, Jiao Zhao, Qinghua Liao, Liang Chen, Xiaoli Zhang, Lin Zhou
Frontiers in Microbiology.2020;[Epub] CrossRef - Glycopeptidolipids, a Double-Edged Sword of the Mycobacterium abscessus Complex
Ana Victoria Gutiérrez, Albertus Viljoen, Eric Ghigo, Jean-Louis Herrmann, Laurent Kremer
Frontiers in Microbiology.2018;[Epub] CrossRef - Role of the Mycobacterium marinum ESX-1 Secretion System in Sliding Motility and Biofilm Formation
Li-Yin Lai, Tzu-Lung Lin, Yi-Yin Chen, Pei-Fang Hsieh, Jin-Town Wang
Frontiers in Microbiology.2018;[Epub] CrossRef
- Drugs for treating infections caused by non-tubercular mycobacteria: a narrative review from the study group on mycobacteria of the Italian Society of Infectious Diseases and Tropical Medicine
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