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Research Support, Non-U.S. Gov't
- Screening of Genes Related to Methylglyoxal Susceptibility
- Insook Kim , Joonho Kim , Bumchan Min , Changhan Lee , Chankyu Park
- J. Microbiol. 2007;45(4):339-343.
- DOI: https://doi.org/2563 [pii]
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Abstract
- Methylglyoxal (MG) is a reactive metabolite known to accumulate in certain physiological conditions. We attempted to isolate genes associated with this metabolite by genome-wide mutagenesis with TnphoA derivative. After screening on methylglyoxal-containing plate, we obtained insertions in three different genes, ydbD, yjjQ, and yqiI, which gave rise to reproducible MG-sensitive phenotypes in glyoxalase-deficient strain. In addition to its MG sensitivity, the insertion in yqiI exhibited an impaired motility resulting from a reduced flagellar expression.
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