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- A histone deacetylase, MoHOS2 regulates asexual development and virulence in the rice blast fungus
- Jongjune Lee , Jae-Joon Lee , Junhyun Jeon
- J. Microbiol. 2019;57(12):1115-1125. Published online November 22, 2019
- DOI: https://doi.org/10.1007/s12275-019-9363-5
- 52 View
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- 15 Web of Science
- 16 Crossref
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Abstract
- Histone acetylation/deacetylation represent a general and efficient epigenetic mechanism through which fungal cells control gene expression. Here we report developmental requirement of MoHOS2-mediated histone deacetylation (HDAC) for the rice blast fungus, Magnaporthe oryzae. Structural similarity and nuclear localization indicated that MoHOS2 is an ortholog of Saccharomyces cerevisiae Hos2, which is a member of class I histone deacetylases and subunit of Set3 complex. Deletion of MoHOS2 led to 25% reduction in HDAC activity, compared to the wild-type, confirming that it is a bona-fide HDAC. Lack of MoHOS2 caused decrease in radial growth and impinged dramatically on asexual sporulation. Such reduction in HDAC activity and phenotypic defects of ΔMohos2 were recapitulated by a single amino acid change in conserved motif that is known to be important for HDAC activity. Expression analysis revealed up-regulation of MoHOS2 and concomitant down-regulation of some of the key genes involved in asexual reproduction under sporulation-promoting condition. In addition, the deletion mutant exhibited defect in appressorium formation from both germ tube tip and hyphae. As a result, ΔMohos2 was not able to cause disease symptoms. Wound-inoculation showed that the mutant is compromised in its ability to grow inside host plants as well. We found that some of ROS detoxifying genes and known effector genes are de-regulated in the mutant. Taken together, our data suggest that MoHOS2-dependent histone deacetylation is pivotal for proper timing and induction of transcription of the genes that coordinate developmental changes and host infection in M. oryzae.
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Citations
Citations to this article as recorded by
- Glsirt1-mediated deacetylation of GlCAT regulates intracellular ROS levels, affecting ganoderic acid biosynthesis in Ganoderma lucidum
Jing Han, Lingshuai Wang, Xin Tang, Rui Liu, Liang Shi, Jing Zhu, Mingwen Zhao
Free Radical Biology and Medicine.2024; 216: 1. CrossRef - Histone (de)acetylation in epigenetic regulation of Phytophthora pathobiology
Yufeng Guan, Joanna Gajewska, Jolanta Floryszak‐Wieczorek, Umesh Kumar Tanwar, Ewa Sobieszczuk‐Nowicka, Magdalena Arasimowicz‐Jelonek
Molecular Plant Pathology.2024;[Epub] CrossRef - FolSas2 is a regulator of early effector gene expression during Fusarium oxysporum infection
Limin Song, Yalei Wang, Fahui Qiu, Xiaoxia Li, Jingtao Li, Wenxing Liang
New Phytologist.2024;[Epub] CrossRef - Regulatory roles of epigenetic modifications in plant-phytopathogen interactions
Zeng Tao, Fei Yan, Matthias Hahn, Zhonghua Ma
Crop Health.2023;[Epub] CrossRef - The additional PRC2 subunit and Sin3 histone deacetylase complex are required for the normal distribution of H3K27me3 occupancy and transcriptional silencing in Magnaporthe oryzae
Chuyu Lin, Zhongling Wu, Huanbin Shi, Jinwei Yu, Mengting Xu, Fucheng Lin, Yanjun Kou, Zeng Tao
New Phytologist.2022; 236(2): 576. CrossRef - Regulatory Roles of Histone Modifications in Filamentous Fungal Pathogens
Yiling Lai, Lili Wang, Weilu Zheng, Sibao Wang
Journal of Fungi.2022; 8(6): 565. CrossRef - Polycomb Repressive Complex 2-Mediated H3K27 Trimethylation Is Required for Pathogenicity in Magnaporthe oryzae
Zhongling Wu, Jiehua Qiu, Huanbin Shi, Chuyu Lin, Jiangnan Yue, Zhiquan Liu, Wei Xie, Naweed I. Naqvi, Yanjun Kou, Zeng Tao
Rice Science.2022; 29(4): 363. CrossRef - Protein acetylation and deacetylation in plant‐pathogen interactions
Jing Wang, Chao Liu, Yun Chen, Youfu Zhao, Zhonghua Ma
Environmental Microbiology.2021; 23(9): 4841. CrossRef - Emerging Roles of Posttranslational Modifications in Plant-Pathogenic Fungi and Bacteria
Wende Liu, Lindsay Triplett, Xiao-Lin Chen
Annual Review of Phytopathology.2021; 59(1): 99. CrossRef - Fungal Lysine Deacetylases in Virulence, Resistance, and Production of Small Bioactive Compounds
Ingo Bauer, Stefan Graessle
Genes.2021; 12(10): 1470. CrossRef - A Histone Deacetylase, Magnaporthe oryzae RPD3, Regulates Reproduction and Pathogenic Development in the Rice Blast Fungus
Song Hee Lee, Mohamed El-Agamy Farh, Jaejoon Lee, Young Taek Oh, Eunbyeol Cho, Jiyeun Park, Hokyoung Son, Junhyun Jeon, Antonio Di Pietro
mBio.2021;[Epub] CrossRef - The Histone Deacetylases MoRpd3 and MoHst4 Regulate Growth, Conidiation, and Pathogenicity in the Rice Blast Fungus Magnaporthe oryzae
Chaoxiang Lin, Xue Cao, Ziwei Qu, Shulin Zhang, Naweed I. Naqvi, Yi Zhen Deng, Aaron P. Mitchell
mSphere.2021;[Epub] CrossRef - Histone Acetyltransferases and Deacetylases Are Required for Virulence, Conidiation, DNA Damage Repair, and Multiple Stresses Resistance of Alternaria alternata
Haijie Ma, Lei Li, Yunpeng Gai, Xiaoyan Zhang, Yanan Chen, Xiaokang Zhuo, Yingzi Cao, Chen Jiao, Fred G. Gmitter, Hongye Li
Frontiers in Microbiology.2021;[Epub] CrossRef - Function of PoLAE2, a laeA homolog, in appressorium formation and cAMP signal transduction in Pyricularia oryzae
Pradabrat Prajanket, Kim-Chi Thi Vu, Jun Arai, Worawan Sornkom, Ayumi Abe, Teruo Sone
Bioscience, Biotechnology, and Biochemistry.2020; 84(11): 2401. CrossRef - A Histone Deacetylase, MoHDA1 Regulates Asexual Development and Virulence in the Rice Blast Fungus
Taehyun Kim, Song Hee Lee, Young Taek Oh, Junhyun Jeon
The Plant Pathology Journal.2020; 36(4): 314. CrossRef - Protein Acetylation/Deacetylation: A Potential Strategy for Fungal Infection Control
Junzhu Chen, Qiong Liu, Lingbing Zeng, Xiaotian Huang
Frontiers in Microbiology.2020;[Epub] CrossRef
- Glsirt1-mediated deacetylation of GlCAT regulates intracellular ROS levels, affecting ganoderic acid biosynthesis in Ganoderma lucidum
Reviews
- MINIREVIEW] Transcriptional control of sexual development in Cryptococcus neoformans
- Matthew E. Mead , Christina M. Hull
- J. Microbiol. 2016;54(5):339-346. Published online April 20, 2016
- DOI: https://doi.org/10.1007/s12275-016-6080-1
- 47 View
- 0 Download
- 6 Crossref
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Abstract
- Developmental processes are essential for the normal life cycles of many pathogenic fungi, and they can facilitate survival in challenging environments, including the human host. Sexual development of the human fungal pathogen Cryptococcus neoformans not only produces infectious particles (spores) but has also enabled the evolution of new disease-related traits such as drug resistance. Transcription factor networks are essential to the development and pathogenesis of C. neoformans, and a variety of sequence-specific DNA-binding proteins control both key developmental transitions and virulence by regulating the expression of their target genes. In this review we discuss the roles of known transcription factors that harbor important connections to both development and virulence. Recent studies of these transcription factors have identified a common theme in which metabolic, stress, and other responses that are required for sexual development appear to have been co-opted for survival in the human host, thus facilitating pathogenesis. Future work elucidating the connection between development and pathogenesis will provide vital insights into the evolution of complex traits in eukaryotes as well as mechanisms that may be used to combat fungal pathogens.
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Citations
Citations to this article as recorded by- Effect of a Mating Type Gene Editing in Lentinula edodes Using RNP/Nanoparticle Complex
Minseek Kim, Minji Oh, Ji-Hoon Im, Eun-Ji Lee, Hojin Ryu, Hyeon-Su Ro, Youn-Lee Oh
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Sheng Sun, Marco A. Coelho, Márcia David-Palma, Shelby J. Priest, Joseph Heitman
Annual Review of Genetics.2019; 53(1): 417. CrossRef -
Pathways of Pathogenicity: Transcriptional Stages of Germination in the Fatal Fungal Pathogen
Rhizopus delemar
Poppy C. S. Sephton-Clark, Jose F. Muñoz, Elizabeth R. Ballou, Christina A. Cuomo, Kerstin Voelz, Aaron P. Mitchell
mSphere.2018;[Epub] CrossRef - Activation of the Mating Pheromone Response Pathway ofLentinula edodesby Synthetic Pheromones
Byeongsuk Ha, Sinil Kim, Minseek Kim, Hyeon-Su Ro
Mycobiology.2018; 46(4): 407. CrossRef
- Effect of a Mating Type Gene Editing in Lentinula edodes Using RNP/Nanoparticle Complex
- REVIEW] Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans
- Lois M. Douglas , James B. Konopka
- J. Microbiol. 2016;54(3):178-191. Published online February 27, 2016
- DOI: https://doi.org/10.1007/s12275-016-5621-y
- 64 View
- 0 Download
- 35 Crossref
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Abstract
- Candida albicans is a human fungal pathogen capable of causing lethal systemic infections. The plasma membrane plays key roles in virulence because it not only functions as a protective barrier, it also mediates dynamic functions including secretion of virulence factors, cell wall synthesis, invasive hyphal morphogenesis, endocytosis, and nutrient uptake. Consistent with this functional complexity, the plasma membrane is composed of a wide array of lipids and proteins. These components are organized into distinct domains that will be the topic of this review. Some of the plasma membrane domains that will be described are known to act as scaffolds or barriers to diffusion, such as MCC/eisosomes, septins, and sites of contact with the endoplasmic reticulum. Other zones mediate dynamic processes, including secretion, endocytosis, and a special region at hyphal tips that facilitates rapid growth. The highly organized architecture of the plasma membrane facilitates the coordination of diverse functions and promotes the pathogenesis of C. albicans.
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Citations
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