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- A murine colitis model developed using a combination of dextran sulfate sodium and Citrobacter rodentium
- Jin-Il Park , Sun-Min Seo , Jong-Hyung Park , Hee-Yeon Jeon , Jun-Young Kim , Seung-Hyun Ryu , Yang-Kyu Choi
- J. Microbiol. 2018;56(4):272-279. Published online April 2, 2018
- DOI: https://doi.org/10.1007/s12275-018-7504-x
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- 7 Crossref
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Abstract
- Adult mice were treated with dextran sulfate sodium (DSS) and infected with Citrobacter rodentium for developing a novel murine colitis model. C57BL/6N mice (7-week-old) were divided into four groups. Each group composed of control, dextran sodium sulfate-treated (DSS), C. rodentiuminfected (CT), and DSS-treated and C. rodentium-infected (DSS-CT) mice. The DSS group was administered 1% DSS in drinking water for 7 days. The CT group was supplied with normal drinking water for 7 days and subsequently infected with C. rodentium via oral gavage. The DSS-CT group was supplied with 1% DSS in drinking water for 7 days and subsequently infected with C. rodentium via oral gavage. The mice were sacrificed 10 days after the induction of C. rodentium infection. The DSS-CT group displayed significantly shorter colon length, higher spleen to body weight ratio, and higher histopathological score compared to the other three groups. The mRNA expression levels of tumor necrosis factor (TNF)-α and interferon (INF)-γ were significantly upregulated; however, those of interleukin (IL)-6 and IL-10 were significantly downregulated in the DSS-CT group than in the control group. These results demonstrated that a combination of low DSS concentration (1%) and C. rodentium infection could effectively induce inflammatory bowel disease (IBD) in mice. This may potentially be used as a novel IBD model, in which colitis is induced in mice by the combination of a chemical and a pathogen.
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Citations
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- Compound Xuejie Preparation Improved Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Mitigating Inflammation-Induced Damage and Downregulating TNF-α Expression
M.M. Yajiao Zhao, M.D. Lin Jin, M.M. Xiaolong Yuan, M.D. Xiaochuan Liu, M.M. Guiming Zang
International Journal of Pharmacology.2024; 20(4): 652. CrossRef - Development of a novel complex inflammatory bowel disease mouse model: Reproducing human inflammatory bowel disease etiologies in mice
Sun-Min Seo, Na-Won Kim, Eun-Seon Yoo, Ji-Hun Lee, Ah-Reum Kang, Han-Bi Jeong, Won-Yong Shim, Dong-Hyun Kim, Young-Jun Park, Kieun Bae, Kyong-Ah Yoon, Yang-Kyu Choi, Pradeep Dudeja
PLOS ONE.2024; 19(11): e0311310. CrossRef - Protective Role of the Toll-Like Receptor 5 Agonist KMRC011 against Murine Colitis Induced by Citrobacter rodentium and Dextran Sulfate Sodium
Jun-Young Kim, Sun-Min Seo, Han-Woong Kim, Woo-Jong Lee, Yang-Kyu Choi
Journal of Microbiology and Biotechnology.2023; 33(1): 35. CrossRef - The inhibition of HACE1 ameliorates inflammatory responses in citrobacter rodentium-induced murine colitis through Nrf2/ NLRP3 signaling pathway
Ting QIU, Lu NIU, Yu ZHANG, Yifei LV
Food Science and Technology.2023;[Epub] CrossRef - Association between intestinal microbiota and inflammatory bowel disease
Yunchang Zhang, Xuemeng Si, Ling Yang, Hui Wang, Ye Sun, Ning Liu
Animal Models and Experimental Medicine.2022; 5(4): 311. CrossRef - Noni juice-fortified yogurt mitigates dextran sodium sulfate-induced colitis in mice through the modulation of inflammatory cytokines
So-Hee Kwon, Damini Kothari, Hae-In Jung, Jeong-Min Lim, Woong-Lae Kim, Hyuk-Cheol Kwon, Sung-Gu Han, Sun-Min Seo, Yang-Kyu Choi, Soo-Ki Kim
Journal of Functional Foods.2021; 86: 104652. CrossRef - Probiotic Bacillus cereus Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice through Improvement of the Intestinal Barrier Function, Anti-Inflammation, and Gut Microbiota Modulation
Kangliang Sheng, Yifan Xu, Xiaowei Kong, Jingmin Wang, Xiangdong Zha, Yongzhong Wang
Journal of Agricultural and Food Chemistry.2021; 69(49): 14810. CrossRef
- Compound Xuejie Preparation Improved Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Mitigating Inflammation-Induced Damage and Downregulating TNF-α Expression
- A lactic acid bacterium isolated from kimchi ameliorates intestinal inflammation in DSS-induced colitis
- Jin-Soo Park , Inseong Joe , Paul Dong Rhee , Choon-Soo Jeong , Gajin Jeong
- J. Microbiol. 2017;55(4):304-310. Published online January 26, 2017
- DOI: https://doi.org/10.1007/s12275-017-6447-y
- 59 View
- 0 Download
- 45 Crossref
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Abstract
- Some species of lactic acid bacteria have been shown to be beneficial in inflammatory bowel disease (IBD). In the pre-sent study, a strain of lactic acid bacterium (Lactobacillus paracasei LS2) was isolated from the Korean food, kimchi, and was shown to inhibit the development of experimental colitis induced by dextran sulfate sodium (DSS). To inves-tigate the role of LS2 in IBD, mice were fed DSS in drinking water for seven days along with LS2 bacteria which were administered intragastrically to some of the mice, while phos-phate-buffered saline (PBS) was administered to others (the controls). The administration of LS2 reduced body weight loss and increased survival, and disease activity indexes (DAI) and histological scores indicated that the severity of colitis was significantly reduced. The production of inflammatory cy-tokines and myeloperoxidase (MPO) activity also decreased. Flow cytometry analysis showed that the number of Th1 (IFN-γ) population cells was significantly reduced in the LS2- administered mice compared with the controls. The admini-stration of LS2 induced the increase of CD4+FOXP3+ Treg cells, which are responsible for IL-10. Numbers of macro-phages (CD11b+ F4/80+), and neutrophils (CD11b+ Gr-1+) among lamina propria lymphocytes (LPL) were also reduced. These results indicate that LS2 has an anti-inflammatory effect and ameliorates DSS-induced colitis.
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Citations
Citations to this article as recorded by- Galectin from Trichinella spiralis alleviates DSS-induced colitis in mice by regulating the intestinal microbiota
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- Galectin from Trichinella spiralis alleviates DSS-induced colitis in mice by regulating the intestinal microbiota
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