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- Growth Phase-dependent Roles of Sir2 in Oxidative Stress Resistance and Chronological Lifespan in Yeast
- Woo Kyu Kang , Yeong Hyeock Kim , Byoung-Soo Kim , Jeong-Yoon Kim
- J. Microbiol. 2014;52(8):652-658. Published online July 5, 2014
- DOI: https://doi.org/10.1007/s12275-014-4173-2
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- 9 Crossref
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Abstract
- Silent Information Regulator 2 (Sir2), a conserved NAD+- dependent histone deacetylase, has been implicated as one of the key factors in regulating stress response and longevity. Here, we report that the role of Sir2 in oxidative stress resistance and chronological lifespan is dependent on growth phase in yeast. In exponential phase, sir2Δ cells were more resistant to H2O2 stress and had a longer chronological lifespan than wild type. By contrast, in post-diauxic phase, sir2Δ cells were less resistant to H2O2 stress and had a shorter chronological lifespan than wild type cells. Similarly, the expression of antioxidant genes, which are essential to cope with oxidative stress, was regulated by Sir2 in a growth phasedependent manner. Collectively, our findings highlight the importance of the metabolic state of the cell in determining whether Sir2 can protect against or accelerate cellular aging of yeast.
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Citations
Citations to this article as recorded by
- RNA-sequencing exploration on SIR2 and SOD genes in Polyalthia longifolia leaf methanolic extracts (PLME) mediated anti-aging effects in Saccharomyces cerevisiae BY611 yeast cells
Manisekaran Hemagirri, Yeng Chen, Subash C. B. Gopinath, Mohd Adnan, Mitesh Patel, Sreenivasan Sasidharan
Biogerontology.2024; 25(4): 705. CrossRef - The intricate role of Sir2 in oxidative stress response during the post-diauxic phase in Saccharomyces cerevisiae
Yeong Hyeock Kim, Ji-In Ryu, Mayur Nimbadas Devare, Juhye Jung, Jeong-Yoon Kim
Frontiers in Microbiology.2023;[Epub] CrossRef - Inactivation of MrSir2 in Monascus ruber Influenced the Developmental Process and the Production of Monascus Azaphilone Pigments
Jing Zhang, Yudan Yang, Zejing Mao, Qingqing Yan, Qi Chen, Ming Yi, Yanchun Shao
Applied Biochemistry and Biotechnology.2022; 194(12): 5702. CrossRef - Histone deacetylase SirE regulates development, DNA damage response and aflatoxin production in Aspergillus flavus
Meifang Wen, Huahui Lan, Ruilin Sun, Xuan Chen, Xin Zhang, Zhuo Zhu, Can Tan, Jun Yuan, Shihua Wang
Environmental Microbiology.2022; 24(11): 5596. CrossRef - Differential protein expression and post-translational modifications in metronidazole-resistant Giardia duodenalis
Samantha J Emery, Louise Baker, Brendan R E Ansell, Mehdi Mirzaei, Paul A Haynes, Malcom J McConville, Staffan G Svärd, Aaron R Jex
GigaScience.2018;[Epub] CrossRef - HST1 increases replicative lifespan of a sir2Δ mutant in the absence of PDE2 in Saccharomyces cerevisiae
Woo Kyu Kang, Mayur Devare, Jeong-Yoon Kim
Journal of Microbiology.2017; 55(2): 123. CrossRef - Sirt1: Role Under the Condition of Ischemia/Hypoxia
Xiaofei Meng, Jin Tan, Mengmeng Li, Shuling Song, Yuyang Miao, Qiang Zhang
Cellular and Molecular Neurobiology.2017; 37(1): 17. CrossRef - A haploproficient interaction of the transaldolase paralogue NQM1 with the transcription factor VHR1 affects stationary phase survival and oxidative stress resistance
Steve Michel, Markus A Keller, Mirjam MC Wamelink, Markus Ralser
BMC Genetics.2015;[Epub] CrossRef - Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast
Woo Kyu Kang, Yeong Hyeock Kim, Hyun Ah Kang, Ki-Sun Kwon, Jeong-Yoon Kim
eLife.2015;[Epub] CrossRef
- RNA-sequencing exploration on SIR2 and SOD genes in Polyalthia longifolia leaf methanolic extracts (PLME) mediated anti-aging effects in Saccharomyces cerevisiae BY611 yeast cells
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