MSK
Search
- Page Path
- HOME > Search
Journal Article
- Role of putative virulence traits of Campylobacter jejuni in regulating differential host immune responses
- Ankita Singh , Amirul Islam Mallick
- J. Microbiol. 2019;57(4):298-309. Published online February 22, 2019
- DOI: https://doi.org/10.1007/s12275-019-8165-0
- 54 View
- 0 Download
- 13 Web of Science
- 10 Crossref
-
Abstract
- Among the major enteric pathogens, Campylobacter jejuni is considered an important source of diarrheal illness in humans. In contrast to the acute gastroenteritis in humans, C. jejuni exhibits prolonged cecal colonization at a high level with little or no pathology in chickens. Although several known virulence determinants of C. jejuni have been found to be associated with a higher degree of pathogenesis in humans, to date, little is known about their functions in the persistent colonization of chickens. The present study was undertaken to assess the role of C. jejuni in imparting differential host immune responses in human and chicken cells. Based on the abundance of major genes encoding virulence factors (GEVFs), we used a particular isolate that harbors the cadF, flaA, peb1, racR, ciaB, cdtB, and hcp genes. This study showed that hypervirulent C. jejuni isolate that encodes a functional type VI secretion system (T6SS) has a greater ability to invade and create characteristic “attaching and effacing” lesions in human INT407 compared to primary chicken embryo intestinal cells (CEICs). Furthermore, we demonstrated that the higher bacterial invasion in human INT407 triggered higher levels of expression of major proinflammatory cytokines, such as IL- 1β and IL-6, and significant downregulation of IL-17A gene expression (P ≤ 0.05). The findings of the present study suggest that the enhanced ability of C. jejuni to invade human cells is tightly regulated by proinflammatory cytokines in the gut and possibly holds the keys to the observed differences in pathogenesis between human and chicken cells.
-
Citations
Citations to this article as recorded by
- Targeted Bioimaging of Microencapsulated Recombinant LAB Vector Expressing Fluorescent Reporter Protein: A Non-invasive Approach for Microbial Tracking
Prakash Biswas, Afruja Khan, Amirul Islam Mallick
ACS Biomaterials Science & Engineering.2024; 10(8): 5210. CrossRef - Identification and functional characterization of putative ligand binding domain(s) of JlpA protein of Campylobacter jejuni
Chandan Gorain, Subhadeep Gupta, S.S. Mahafujul Alam, Mehboob Hoque, Andrey V. Karlyshev, Amirul Islam Mallick
International Journal of Biological Macromolecules.2024; 264: 130388. CrossRef - Heterogeneity and Compositional Diversities of Campylobacter jejuni Outer Membrane Vesicles (OMVs) Drive Multiple Cellular Uptake Processes
Afruja Khan, Avijit Sardar, Pradip K. Tarafdar, Amirul I. Mallick
ACS Infectious Diseases.2023; 9(11): 2325. CrossRef - Multimodal Biofilm Inactivation Using a Photocatalytic Bismuth Perovskite–TiO2–Ru(II)polypyridyl-Based Multisite Heterojunction
Noufal Kandoth, Sonu Pratap Chaudhary, Subhadeep Gupta, Kumari Raksha, Atin Chatterjee, Shresth Gupta, Safakath Karuthedath, Catherine S. P. De Castro, Frédéric Laquai, Sumit Kumar Pramanik, Sayan Bhattacharyya, Amirul Islam Mallick, Amitava Das
ACS Nano.2023; 17(11): 10393. CrossRef - In Silico and In Vitro Analysis of Helicobacter pullorum Type Six Secretory Protein Hcp and Its Role in Bacterial Invasion and Pathogenesis
Kashaf Javed, Farzana Gul, Rashda Abbasi, Sidra Batool, Zobia Noreen, Habib Bokhari, Sundus Javed
Current Microbiology.2022;[Epub] CrossRef - Gut Microbe-Derived Outer Membrane Vesicles: A Potential Platform to Control Cecal Load of Campylobacter jejuni
Ankita Singh, Afruja Khan, Tamal Ghosh, Samiran Mondal, Amirul I. Mallick
ACS Infectious Diseases.2021; 7(5): 1186. CrossRef - Mucosal delivery of live Lactococcus lactis expressing functionally active JlpA antigen induces potent local immune response and prevent enteric colonization of Campylobacter jejuni in chickens
Chandan Gorain, Ankita Singh, Sudipta Bhattacharyya, Anirban Kundu, Aritraa Lahiri, Subhadeep Gupta, Amirul I. Mallick
Vaccine.2020; 38(7): 1630. CrossRef - Immunopathological properties of the Campylobacter jejuni flagellins and the adhesin CadF as assessed in a clinical murine infection model
Anna-Maria Schmidt, Ulrike Escher, Soraya Mousavi, Nicole Tegtmeyer, Manja Boehm, Steffen Backert, Stefan Bereswill, Markus M. Heimesaat
Gut Pathogens.2019;[Epub] CrossRef - A One Health approach to prevention, treatment, and control of campylobacteriosis
Francesca Schiaffino, James Platts-Mills, Margaret N. Kosek
Current Opinion in Infectious Diseases.2019; 32(5): 453. CrossRef - Immunogenicity and protective efficacy of mucosal delivery of recombinant hcp of Campylobacter jejuni Type VI secretion system (T6SS) in chickens
Ankita Singh, Khairun Nisaa, Sudipta Bhattacharyya, Amirul Islam Mallick
Molecular Immunology.2019; 111: 182. CrossRef
- Targeted Bioimaging of Microencapsulated Recombinant LAB Vector Expressing Fluorescent Reporter Protein: A Non-invasive Approach for Microbial Tracking
First
Prev
TOP
