MSK
Search
- Page Path
- HOME > Search
Research Support, Non-U.S. Gov't
- Superinfection Exclusion Reveals Heteroimmunity between Pseudomonas aeruginosa Temperate Phages
- In-Young Chung , Hee-Won Bae , Hye-Jung Jang , Bi-o Kim , You-Hee Cho
- J. Microbiol. 2014;52(6):515-520. Published online May 29, 2014
- DOI: https://doi.org/10.1007/s12275-014-4012-5
- 55 View
- 0 Download
- 4 Crossref
-
Abstract
- Temperate siphophages (MP29, MP42, and MP48) were isolated from the culture supernatant of clinical Pseudomonas aeruginosa isolates. The complete nucleotide sequences and annotation of the phage genomes revealed the overall synteny to the known temperate P. aeruginosa phages such as MP22, D3112, and DMS3. Genome-level sequence analysis showed the conservation of both ends of the linear genome and the divergence at the previously identified dissimilarity regions (R1 to R9). Protein sequence alignment of the c repressor (ORF1) of each phage enabled us to divide the six phages into two groups: D3112 group (D3112, MP29, MP42, and MP48) and MP22 group (MP22 and DMS3). Superinfection exclusion was observed between the phages belonging to the same group, which was mediated by the specific interaction between the c repressor and the cognate operator. Based on these, we suggest that the temperate siphophages prevalent in the clinical strains of P. aeruginosa represent at least two distinct heteroimmunity groups.
-
Citations
Citations to this article as recorded by
- Phage against the Machine: The SIE-ence of Superinfection Exclusion
Michael J. Bucher, Daniel M. Czyż
Viruses.2024; 16(9): 1348. CrossRef - Transposition Behavior Revealed by High-Resolution Description of Pseudomonas Aeruginosa Saltovirus Integration Sites
Gilles Vergnaud, Cédric Midoux, Yann Blouin, Maria Bourkaltseva, Victor Krylov, Christine Pourcel
Viruses.2018; 10(5): 245. CrossRef - Evolutionary Ecology of Prokaryotic Immune Mechanisms
Stineke van Houte, Angus Buckling, Edze R. Westra
Microbiology and Molecular Biology Reviews.2016; 80(3): 745. CrossRef - A phage protein that inhibits the bacterial ATPase required for type IV pilus assembly
In-Young Chung, Hye-Jeong Jang, Hee-Won Bae, You-Hee Cho
Proceedings of the National Academy of Sciences.2014; 111(31): 11503. CrossRef
- Phage against the Machine: The SIE-ence of Superinfection Exclusion
First
Prev
TOP
