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- MINIREVIEW] Advances in novel influenza vaccines: a patent review
- Jae-Min Song
- J. Microbiol. 2016;54(6):403-412. Published online May 27, 2016
- DOI: https://doi.org/10.1007/s12275-016-6176-7
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- 1 Crossref
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Abstract
- The threat of a major human influenza pandemic such as the avian H5N1 or the 2009 new H1N1 has emphasized the need for effective prevention strategies to combat these pathogens. Although egg based influenza vaccines have been well established for a long time, it remains an ongoing public health need to develop alternative production methods that ensures improved safety, efficacy, and ease of administration compared with conventional influenza vaccines. This article is intended to cover some of the recent advances and related patents on the development of influenza vaccines including live attenuated, cell based, genomic and synthetic peptide vaccines.
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Citations
Citations to this article as recorded by
- Plant-made virus-like particles bearing influenza hemagglutinin (HA) recapitulate early interactions of native influenza virions with human monocytes/macrophages
Alexander I. Makarkov, Sabrina Chierzi, Stéphane Pillet, Keith K. Murai, Nathalie Landry, Brian J. Ward
Vaccine.2017; 35(35): 4629. CrossRef
- Plant-made virus-like particles bearing influenza hemagglutinin (HA) recapitulate early interactions of native influenza virions with human monocytes/macrophages
Research Support, Non-U.S. Gov't
- A Potent Brucella abortus 2308 Δery Live Vaccine Allows for the Differentiation between Natural and Vaccinated Infection
- Junbo Zhang , Shuanghong Yin , Fei Guo , Ren Meng , Chuangfu Chen , Hui Zhang , Zhiqiang Li , Qiang Fu , Huijun Shi , Shengwei Hu , Wei Ni , Tiansen Li , Ke Zhang
- J. Microbiol. 2014;52(8):681-688. Published online July 4, 2014
- DOI: https://doi.org/10.1007/s12275-014-3689-9
- 55 View
- 0 Download
- 15 Crossref
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Abstract
- Brucellosis is a globally distributed zoonotic disease that causes animal and human diseases. However, the current Brucella abortus vaccines (S19 and RB51) are deficient; they can cause abortion in pregnant animals. Moreover, when the vaccine S19 is used, tests cannot differentiate natural from vaccinated infection. Therefore, a safer and more potent vaccine is needed. A Brucella abortus 2308 ery promoter mutant (Δery) was constructed to overcome these drawbacks. The growth of the Δery mutant was significantly attenuated in macrophages and mice and induced high protective immunity in mice. Moreover, Δery induced an anti-Brucellaspecific IgG (immunoglobulin G) response and stimulated the expression of interferon-gamma (INF-γ) and interleukin-4 (IL-4). Furthermore, the expression of EryA antigen allowed for the serological differentiation between natural and vaccinated infection in mice. These results indicate that the Δery mutant is a potential attenuated live vaccine candidate against virulent Brucella abortus 2308 (S2308) infection.
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Citations
Citations to this article as recorded by- Disruption of Erythritol Catabolism via the Deletion of Fructose-Bisphosphate Aldolase (Fba) and Transaldolase (Tal) as a Strategy to Improve the Brucella Rev1 Vaccine
Aitor Elizalde-Bielsa, Leticia Lázaro-Antón, María Jesús de Miguel, Pilar M. Muñoz, Raquel Conde-Álvarez, Amaia Zúñiga-Ripa
International Journal of Molecular Sciences.2024; 25(20): 11230. CrossRef - Establishment of picodroplet-based co-culture system to improve erythritol production in Yarrowia lipolytica
Shuang Li, Yuan Zhang, Lu Li, Yaomeng Yuan, Haoxuan Sun, Xin-Hui Xing, Xiaoyan Wang, Chong Zhang
Biochemical Engineering Journal.2023; 198: 109036. CrossRef - Characterization of Brucella abortus Mutant A19mut2, a Potential DIVA Vaccine Candidate with a Modification on Lipopolysaccharide
Hosny Ahmed Abdelgawad, Zhengmin Lian, Yi Yin, Tian Fang, Mingxing Tian, Shengqing Yu
Vaccines.2023; 11(7): 1273. CrossRef - Evaluation of Brucellosis Vaccines: A Comprehensive Review
Mohsen Heidary, Shirin Dashtbin, Roya Ghanavati, Marzie Mahdizade Ari, Narjess Bostanghadiri, Atieh Darbandi, Tahereh Navidifar, Malihe Talebi
Frontiers in Veterinary Science.2022;[Epub] CrossRef - Advances and prospects of transcription‐factor‐based biosensors in high‐throughput screening for cell factories construction
Changfan Li, Chang Wang, Jiang Zhu, Feng Xue, Xiaoman Sun, Yang Gu
Food Bioengineering.2022; 1(2): 135. CrossRef - Development of Brucella melitensis Rev.1 ΔOmp19 mutants with DIVA feature and comparison of their efficacy against three commercial vaccines in a mouse model
Ali Uslu, Osman Erganis
Molecular Immunology.2021; 133: 44. CrossRef - Insights into irr and rirA gene regulation on the virulence of Brucella melitensis M5-90
Huan Zhang, Benben Wang, Wenxing Wu, Xiaoyu Deng, Zhiran Shao, Jihai Yi, Zhen Wang, Ningning Yang, Yong Wang, Yuanzhi Wang, Chuangfu Chen
Canadian Journal of Microbiology.2020; 66(5): 351. CrossRef - Combining genetically-encoded biosensors with high throughput strain screening to maximize erythritol production in Yarrowia lipolytica
Xueliang Qiu, Peng Xu, Xinrui Zhao, Guocheng Du, Juan Zhang, Jianghua Li
Metabolic Engineering.2020; 60: 66. CrossRef - Research progress on the role of immune cells in Brucella infection
Jin Zhang
Infection International.2018; 7(1): 23. CrossRef - Development and evaluation of in murine model, of an improved live-vaccine candidate against brucellosis from to Brucella melitensis vjbR deletion mutant
Zhiqiang Li, Shuli Wang, Hui Zhang, Li Xi, Jinliang Zhang, Xiaogen Zhang, Qingfeng Zhou, Jihai Yi, Min Li, Weihua Zhang, Junbo Zhang
Microbial Pathogenesis.2018; 124: 250. CrossRef - Expression and regulation of the ery operon of Brucella melitensis in human trophoblast cells
Hui Zhang, Xiaoxia Dou, Zhiqiang Li, Yu Zhang, Jing Zhang, Fei Guo, Yuanzhi Wang, Zhen Wang, Tiansen Li, Xinli Gu, Chuangfu Chen
Experimental and Therapeutic Medicine.2016; 12(4): 2723. CrossRef - Protection efficacy of the Brucella abortus ghost vaccine candidate lysed by the N-terminal 24-amino acid fragment (GI24) of the 36-amino acid peptide PMAP-36 (porcine myeloid antimicrobial peptide 36) in murine models
Ae Jeong KWON, Ja Young MOON, Won Kyong KIM, Suk KIM, Jin HUR
Journal of Veterinary Medical Science.2016; 78(10): 1541. CrossRef - Meta-Analysis and Advancement of Brucellosis Vaccinology
Tatiane F. Carvalho, João Paulo A. Haddad, Tatiane A. Paixão, Renato L. Santos, Roy Martin Roop
PLOS ONE.2016; 11(11): e0166582. CrossRef - The Brucella melitensis M5-90 phosphoglucomutase (PGM) mutant is attenuated and confers protection against wild-type challenge in BALB/c mice
Yu Zhang, Tiansen Li, Jing Zhang, Zhiqiang Li, Yan Zhang, Zhen Wang, Hanping Feng, Yuanzhi Wang, Chuangfu Chen, Hui Zhang
World Journal of Microbiology and Biotechnology.2016;[Epub] CrossRef - A Brucella melitensis M5-90 wboA deletion strain is attenuated and enhances vaccine efficacy
Zhi-Qiang Li, Jing-Xue Shi, Wen-Dong Fu, Yu Zhang, Jing Zhang, Zhen Wang, Tian-Sen Li, Chuang-Fu Chen, Fei Guo, Hui Zhang
Molecular Immunology.2015; 66(2): 276. CrossRef
- Disruption of Erythritol Catabolism via the Deletion of Fructose-Bisphosphate Aldolase (Fba) and Transaldolase (Tal) as a Strategy to Improve the Brucella Rev1 Vaccine
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