MSK
Search
- Page Path
- HOME > Search
Review
- MINIREVIEW] Importance of differential identification of Mycobacterium tuberculosis strains for understanding differences in their prevalence, treatment efficacy, and vaccine development
- Hansong Chae , Sung Jae Shin
- J. Microbiol. 2018;56(5):300-311. Published online May 2, 2018
- DOI: https://doi.org/10.1007/s12275-018-8041-3
- 56 View
- 0 Download
- 19 Crossref
-
Abstract
- Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a serious global health problem in the 21st century because of its high mortality. Mtb is an extremely successful human-adapted pathogen that displays a multifactorial ability to control the host immune response and to evade killing by drugs, resulting in the breakdown of BCG vaccine-conferred anti-TB immunity and development of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mtb. Although genetic components of the genomes of the Mtb complex strains are highly conserved, showing over 99% similarity to other bacterial genera, recently accumulated evidence suggests that the genetic diversity of the Mtb complex strains has implications for treatment outcomes, development of MDR/XDR Mtb, BCG vaccine efficacy, transmissibility, and epidemiological outbreaks. Thus, new insights into the pathophysiological features of the Mtb complex strains are required for development of novel vaccines and for control of MDR/XDR Mtb infection, eventually leading to refinement of treatment regimens and the health care system. Many studies have focused on the differential identification of Mtb complex strains belonging to different lineages because of differences in their virulence and geographical dominance. In this review, we discuss the impact of differing genetic characteristics among Mtb complex strains on vaccine efficacy, treatment outcome, development of MDR/ XDR Mtb strains, and epidemiological outbreaks by focusing on the best-adapted human Mtb lineages. We further explore the rationale for differential identification of Mtb strains for more effective control of TB in clinical and laboratory settings by scrutinizing current diagnostic methods.
-
Citations
Citations to this article as recorded by
- Assistance of next-generation sequencing for diagnosis of disseminated Bacillus Calmette-Guerin disease with X-SCID in an infant: a case report and literature review
Haiyang Zhang, Yi Liao, Zhensheng Zhu, Hanmin Liu, Deyuan Li, Sisi Wang
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef - Applications and advances in molecular diagnostics: revolutionizing non-tuberculous mycobacteria species and subspecies identification
Haiyang Zhang, Maoting Tang, Deyuan Li, Min Xu, Yusen Ao, Liangkang Lin
Frontiers in Public Health.2024;[Epub] CrossRef - Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculosis
Meg L. Donovan, Helle Bielefeldt‐Ohmann, Rachel F. Rollo, Stephen J. McPherson, Thomas E. Schultz, Giorgia Mori, Jessica C. Kling, Antje Blumenthal
Immunology.2023; 169(1): 13. CrossRef - Host vs. pathogen evolutionary arms race: Effects of exposure history on individual response to a genetically diverse pathogen
Daniel P. Walsh, Brandi L. Felts, E. Frances Cassirer, Thomas E. Besser, Jonathan A. Jenks
Frontiers in Ecology and Evolution.2023;[Epub] CrossRef - Antimycobacterial Activity of Hedeoma drummondii against Mycobacterium tuberculosis and Non-Tuberculous Mycobacteria
Carmen Molina-Torres, Carlos Pedraza-Rodríguez, Lucio Vera-Cabrera, Jorge Ocampo-Candiani, Catalina Rivas-Morales, Ezequiel Viveros-Valdez
Antibiotics.2023; 12(5): 833. CrossRef - Mycobacterium tuberculosis lineage 4 associated with cavitations and treatment failure
Anabel Ordaz-Vázquez, Pedro Torres-González, Leticia Ferreyra-Reyes, Sergio Canizales-Quintero, Guadalupe Delgado-Sánchez, Lourdes García-García, Alfredo Ponce-De-León, José Sifuentes-Osornio, Miriam Bobadilla-Del-Valle
BMC Infectious Diseases.2023;[Epub] CrossRef - Will we ever eradicate animal tuberculosis?
Christian Gortázar, José de la Fuente, Alberto Perelló, Lucas Domínguez
Irish Veterinary Journal.2023;[Epub] CrossRef - Predominance of the Mycobacterium tuberculosis Beijing strain amongst children from a high tuberculosis burden township in South Africa
Junaid Shaik, Manormoney Pillay, Julie Moodley, Prakash Jeena
Tuberculosis.2022; 136: 102250. CrossRef - Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru
Kattya Lopez, María B. Arriaga, Juan G. Aliaga, Nadia N. Barreda, Oswaldo M. Sanabria, Chuan-Chin Huang, Zibiao Zhang, Ruth García-de-la-Guarda, Leonid Lecca, Anna Cristina Calçada Carvalho, Afrânio L. Kritski, Roger I. Calderon, Igor Mokrousov
PLOS ONE.2021; 16(1): e0243184. CrossRef - In vitro Synergism of Six Antituberculosis Agents Against Drug-Resistant Mycobacterium tuberculosis Isolated from Retreatment Tuberculosis Patients
Ruoyan Ying, Xiaochen Huang, Yaxian Gao, Jie Wang, Yidian Liu, Wei Sha, Hua Yang
Infection and Drug Resistance.2021; Volume 14: 3729. CrossRef - Characterisation of secretome-based immune responses of human leukocytes infected with variousMycobacterium tuberculosislineages
Benjawan Kaewseekhao, Sittiruk Roytrakul, Yodying Yingchutrakul, Marut Laohaviroj, Kanin Salao, Kiatichai Faksri
PeerJ.2021; 9: e11565. CrossRef - Different PPD-stimulated cytokine responses from patients infected with genetically distinct Mycobacterium tuberculosis complex lineages
Paulo Ranaivomanana, Marie Sylvianne Rabodoarivelo, Mame Diarra Bousso Ndiaye, Niaina Rakotosamimanana, Voahangy Rasolofo
International Journal of Infectious Diseases.2021; 104: 725. CrossRef - A review of published spoligotype data indicates the diversity of Mycobacterium tuberculosis from India is under-represented in global databases
Husain Poonawala, Narender Kumar, Sharon J. Peacock
Infection, Genetics and Evolution.2020; 78: 104072. CrossRef - Comparing IS6110‐RFLP, PGRS‐RFLP and IS6110‐Mtb1/Mtb2 PCR methods for genotyping ofMycobacterium tuberculosisisolates
Kh. Ansarin, L. Sahebi, Y. Aftabi, M. Khalili, M. Seyyedi
Journal of Applied Microbiology.2020; 129(4): 1062. CrossRef - Molecular Typing of Mycobacterium Tuberculosis Isolated from Iranian Patients Using Highly Abundant Polymorphic GC-Rich-Repetitive Sequence
Bahram Golestani Eimani, Khalil Ansarin, Leila Sahebi, Maryam Seyyedi
Iranian South Medical Journal.2020; 23(2): 87. CrossRef - Comparison of the Three Molecular Diagnostic Assays for Molecular Identification ofMycobacterium tuberculosisand Nontuberculous Mycobacteria Species in Sputum Samples
Jinyoung Bae, Sung-Bae Park, Ji-Hoi Kim, Mi Ran Kang, Kyung Eun Lee, Sunghyun Kim, Hyunwoo Jin
Biomedical Science Letters.2020; 26(3): 170. CrossRef - Immunogenicity and Vaccine Potential of InsB, an ESAT-6-Like Antigen Identified in the Highly Virulent Mycobacterium tuberculosis Beijing K Strain
Woo Sik Kim, Hongmin Kim, Kee Woong Kwon, Sang-Nae Cho, Sung Jae Shin
Frontiers in Microbiology.2019;[Epub] CrossRef - Molecular characterisation of multidrug-resistantMycobacterium tuberculosisisolates from a high-burden tuberculosis state in Brazil
R. S. Salvato, S. Schiefelbein, R. B. Barcellos, B. M. Praetzel, I. S. Anusca, L. S. Esteves, M. L. Halon, G. Unis, C.F. Dias, S. S. Miranda, I. N. de Almeida, L. J. de Assis Figueredo, E. C. Silva, A. L. Kritski, E. R. Dalla Costa, M. L. R. Rossetti
Epidemiology and Infection.2019;[Epub] CrossRef - DNA markers for tuberculosis diagnosis
Kai Ling Chin, Maria E. Sarmiento, Mohd Nor Norazmi, Armando Acosta
Tuberculosis.2018; 113: 139. CrossRef
- Assistance of next-generation sequencing for diagnosis of disseminated Bacillus Calmette-Guerin disease with X-SCID in an infant: a case report and literature review
First
Prev
TOP
