MSK
Search
- Page Path
- HOME > Search
Review
- [MINIREVIEW] Alanine dehydrogenases in mycobacteria
- Ji-A Jeong , Jeong-Il Oh
- J. Microbiol. 2019;57(2):81-92. Published online January 31, 2019
- DOI: https://doi.org/10.1007/s12275-019-8543-7
- 53 View
- 1 Download
- 12 Web of Science
- 11 Crossref
-
Abstract
- Since NAD(H)-dependent L-alanine dehydrogenase (EC 1.1.4.1; Ald) was identified as one of the major antigens present in culture filtrates of Mycobacterium tuberculosis, many studies on the enzyme have been conducted. Ald catalyzes the reversible conversion of pyruvate to alanine with concomitant oxidation of NADH to NAD+ and has a homohexameric quaternary structure. Expression of the ald genes was observed to be strongly upregulated in M. tuberculosis and Mycobacterium smegmatis grown in the presence of alanine. Furthermore, expression of the ald genes in some mycobacteria was observed to increase under respiration-inhibitory conditions such as oxygen-limiting and nutrient-starvation conditions. Upregulation of ald expression by alanine or under respiration-inhibitory conditions is mediated by AldR, a member of the Lrp/AsnC family of transcriptional regulators. Mycobacterial Alds were demonstrated to be the enzymes required for utilization of alanine as a nitrogen source and to help mycobacteria survive under respiration-inhibitory conditions by maintaining cellular NADH/NAD+ homeostasis. Several inhibitors of Ald have been developed, and their application in combination with respiration-inhibitory antitubercular drugs such as Q203 and bedaquiline was recently suggested.
-
Citations
Citations to this article as recorded by
- Amino Acid Biosynthesis Inhibitors in Tuberculosis Drug Discovery
Michela Guida, Chiara Tammaro, Miriana Quaranta, Benedetta Salvucci, Mariangela Biava, Giovanna Poce, Sara Consalvi
Pharmaceutics.2024; 16(6): 725. CrossRef - Alanine dehydrogenases from four different microorganisms: characterization and their application in L-alanine production
Pengfei Gu, Qianqian Ma, Shuo Zhao, Qiang Li, Juan Gao
Biotechnology for Biofuels and Bioproducts.2023;[Epub] CrossRef - Application of reductive amination by heterologously expressed Thermomicrobium roseum L-alanine dehydrogenase to synthesize L-alanine derivatives
Huri Dedeakayoğulları, Jarkko Valjakka, Ossi Turunen, Berin Yilmazer, Ğarip Demir, Janne Jänis, Barış Binay
Enzyme and Microbial Technology.2023; 169: 110265. CrossRef - A review on enzyme complexes of electron transport chain from Mycobacterium tuberculosis as promising drug targets
Pragya Anand, Yusuf Akhter
International Journal of Biological Macromolecules.2022; 212: 474. CrossRef -
Alanine synthesized by alanine dehydrogenase enables ammonium-tolerant nitrogen fixation in
Paenibacillus sabinae
T27
Qin Li, Haowei Zhang, Yi Song, Minyang Wang, Chongchong Hua, Yashi Li, Sanfeng Chen, Ray Dixon, Jilun Li
Proceedings of the National Academy of Sciences.2022;[Epub] CrossRef - Antibacterial Activity of Squaric Amide Derivative SA2 against Methicillin-Resistant Staphylococcus aureus
Moxi Yu, Yachen Hou, Meiling Cheng, Yongshen Liu, Caise Ling, Dongshen Zhai, Hui Zhao, Yaoyao Li, Yamiao Chen, Xiaoyan Xue, Xue Ma, Min Jia, Bin Wang, Pingan Wang, Mingkai Li
Antibiotics.2022; 11(11): 1497. CrossRef - Mining for Perchlorate Resistance Genes in Microorganisms From Sediments of a Hypersaline Pond in Atacama Desert, Chile
Jorge Díaz-Rullo, Gustavo Rodríguez-Valdecantos, Felipe Torres-Rojas, Luis Cid, Ignacio T. Vargas, Bernardo González, José Eduardo González-Pastor
Frontiers in Microbiology.2021;[Epub] CrossRef - Targeting amino acid metabolism of Mycobacterium tuberculosis for developing inhibitors to curtail its survival
Soujanya D. Yelamanchi, Avadhesha Surolia
IUBMB Life.2021; 73(4): 643. CrossRef - Targeting Non-Replicating Mycobacterium tuberculosis and Latent Infection: Alternatives and Perspectives (Mini-Review)
Anna Egorova, Elena G. Salina, Vadim Makarov
International Journal of Molecular Sciences.2021; 22(24): 13317. CrossRef - Distinctive gene and protein characteristics of extremely piezophilic Colwellia
Logan M. Peoples, Than S. Kyaw, Juan A. Ugalde, Kelli K. Mullane, Roger A. Chastain, A. Aristides Yayanos, Masataka Kusube, Barbara A. Methé, Douglas H. Bartlett
BMC Genomics.2020;[Epub] CrossRef - Comparison of Extracellular Proteins from Virulent and Avirulent Vibrio parahaemolyticus Strains to Identify Potential Virulence Factors
Yu He, Shuai Wang, Xianting Yin, Fengjiao Sun, Bin He, Xiao Liu
Journal of Food Protection.2020; 83(1): 155. CrossRef
- Amino Acid Biosynthesis Inhibitors in Tuberculosis Drug Discovery
First
Prev
TOP
