MSK
Search
- Page Path
- HOME > Search
Research Support, Non-U.S. Gov't
- Functional Analysis of SGR4635-Induced Enhancement of Pigmented Antibiotic Production in Streptomyces lividans
- Won-Jae Chi , Soon-Youl Lee , JaeHag Lee
- J. Microbiol. 2011;49(5):828-833. Published online November 9, 2011
- DOI: https://doi.org/10.1007/s12275-011-1100-7
- 36 View
- 0 Download
- 7 Crossref
-
Abstract
- The Gram-positive mycelium-producing bacterium Streptomyces undergoes complex morphological differentiation after autolytic degradation of the vegetative mycelium. Cell-wall breakdown during growth stimulates cell development and secondary metabolite production by Streptomyces. N-acetylglucosamine (GlcNAc) produced by cell-wall lysis acts as a signal molecule, triggering the production of secondary metabolites in S. coelicolor A3(2). Here, we report that introduction of multiple copies of the GlcNAc-internalizing gene (sgr4635, encoding nagE2) of S. griseus activates actinorhodin and undecylprodigiosin production during the late growth of S. lividans in the absence of GlcNAc. Furthermore, the repressor-type transcriptional regulator DasR binds to two operator sites upstream of sgr4635. Our findings indicate that sgr4635 induces DasR-mediated antibiotic production by internalizing the GlcNAc accumulated from cell-wall lysis.
-
Citations
Citations to this article as recorded by
- Identification and Testing of Antidermatophytic Oxaborole-6-Benzene Sulphonamide Derivative (OXBS) from Streptomyces atrovirens KM192347 Isolated from Soil
Seham Abdel-Shafi, Abdul-Raouf Al-Mohammadi, Taghreed N. Almanaa, Ahmed H. Moustafa, Tamer M. M. Saad, Abdel-Rahman Ghonemey, Immacolata Anacarso, Gamal Enan, Nashwa El-Gazzar
Antibiotics.2020; 9(4): 176. CrossRef - Recent advances in inducing endophytic fungal specialized metabolites using small molecule elicitors including epigenetic modifiers
Rufin Marie Kouipou Toghueo, Dinkar Sahal, Fabrice Fekam Boyom
Phytochemistry.2020; 174: 112338. CrossRef - The Cellobiose Sensor CebR Is the Gatekeeper of Streptomyces scabies Pathogenicity
Isolde M. Francis, Samuel Jourdan, Steven Fanara, Rosemary Loria, Sébastien Rigali, Anne K. Vidaver
mBio.2015;[Epub] CrossRef - Fungi Treated with Small Chemicals Exhibit Increased Antimicrobial Activity against Facultative Bacterial and Yeast Pathogens
Christoph Zutz, Dragana Bandian, Bernhard Neumayer, Franz Speringer, Markus Gorfer, Martin Wagner, Joseph Strauss, Kathrin Rychli
BioMed Research International.2014; 2014: 1. CrossRef - Small Chemical Chromatin Effectors Alter Secondary Metabolite Production in Aspergillus clavatus
Christoph Zutz, Agnieszka Gacek, Michael Sulyok, Martin Wagner, Joseph Strauss, Kathrin Rychli
Toxins.2013; 5(10): 1723. CrossRef - Molecular Regulation of Antibiotic Biosynthesis in Streptomyces
Gang Liu, Keith F. Chater, Govind Chandra, Guoqing Niu, Huarong Tan
Microbiology and Molecular Biology Reviews.2013; 77(1): 112. CrossRef - Antibiotics produced by Streptomyces
Rudi Emerson de Lima Procópio, Ingrid Reis da Silva, Mayra Kassawara Martins, João Lúcio de Azevedo, Janete Magali de Araújo
The Brazilian Journal of Infectious Diseases.2012; 16(5): 466. CrossRef
- Identification and Testing of Antidermatophytic Oxaborole-6-Benzene Sulphonamide Derivative (OXBS) from Streptomyces atrovirens KM192347 Isolated from Soil
First
Prev
TOP
