Journal of Microbiology

Research Support, Non-U.S. Gov't

Kinetic Evaluation of Products Inhibition to Succinic Acid Producers Escherichia coli NZN111, AFP111, BL21, and Actinobacillus succinogenes 130ZT: Qiang Li , Dan Wang , Yong Wu , Maohua Yang , Wangliang Li , Jianmin Xing , Zhiguo Su; J. Microbiol. 2010;48(3):290-296. Published online June 23, 2010; DOI: https://doi.org/10.1007/s12275-010-9262-2

68 View
0 Download
35 Crossref

Succinic acid is one of the platform compounds and its production via natural feedstocks has drawn worldwide concerns. To evaluate the inhibitory effects of fermentation products on the growth of Actinobacillus succinogenes 130ZT and Escherichia coli NZN111, AFP111, BL21, fermentations with addition of individual products in medium were carried out. The cell growth was inhibited when the concentrations of formate, acetate, lactate, and succinate were at range of 8.8-17.6 g/L, 10-40 g/L, 9-18 g/L, and 10-80 g/L, respectively. For these two species of bacteria, E. coli was more resistant to acid products than A. succinogenes, while both endured succinate rather than by-products. As a result of end product inhibition, succinate production yield by A. succinogenes decreased from 1.11 to 0.49 g/g glucose. Logistic and Monod mathematical models were presented to simulate the inhibition kinetics. The Logistic model was found more suitable for describing the overall synergistic inhibitory effects.

Citations

Citations to this article as recorded by

A process-based dynamic model for succinic acid production by Actinobacillus succinogenes: regulatory role of ATP/ADP balance
Emiliano Salucci, Fabrizio Cartenì, Francesco Giannino, Elisabetta de Alteriis, Francesca Raganati, Stefano Mazzoleni
Frontiers in Microbiology.2025;[Epub] CrossRef
Substrate Gas Utilization and C3/C4 Metabolic Analysis of Actinobacillus succinogenes: Integration into a Model for Fermentation Prediction in BES
Julian Tix, Joshua Bode, Leon Gotthardt, Nils Tippkötter
Fermentation.2025; 11(5): 263. CrossRef
On the succinic acid production from xylose by growing and resting cells of Actinobacillus succinogenes: a comparison
Itziar A. Escanciano, Miguel Ladero, Victoria E. Santos
Biomass Conversion and Biorefinery.2024; 14(5): 6533. CrossRef
Inhibitors derived from wheat straw hydrolysate can affect the production of succinic acid by Actinobacillus succinogenes
Patrizia Casella, Raffaele Loffredo, Maria Antonietta Rao, Roberto Balducchi, Federico Liuzzi, Isabella De Bari, Antonio Molino
Process Biochemistry.2024; 147: 228. CrossRef
Enhancement of Succinic Acid Production by Actinobacillus succinogenes in an Electro-Bioreactor
Julian Tix, Leon Gotthardt, Joshua Bode, Burak Karabacak, Janne Nordmann, Jan-Niklas Hengsbach, Roland Ulber, Nils Tippkötter
Fermentation.2024; 10(10): 504. CrossRef
Development of a Simple and Robust Kinetic Model for the Production of Succinic Acid from Glucose Depending on Different Operating Conditions
Itziar A. Escanciano, Miguel Ladero, Victoria E. Santos, Ángeles Blanco
Fermentation.2023; 9(3): 222. CrossRef
Modelling of end-product inhibition in fermentation
Adrie J.J. Straathof
Biochemical Engineering Journal.2023; 191: 108796. CrossRef
Simultaneous biosuccinic production and biogas upgrading: Exploring the potential of sugar-based confectionery waste within a biorefinery concept
Juan Carlos López, Rocío Monsonís, Enrique López de los Mozos, Francisco Heredia, Paz Gómez-Pérez
Bioresource Technology.2023; 384: 129362. CrossRef
Inhibition kinetics of bio-based succinic acid production by the yeast Yarrowia lipolytica
Chong Li, Yi Xiao, Zhenyu Sang, Ziying Yang, Tang Xu, Xiaofeng Yang, Jianbin Yan, Carol Sze Ki Lin
Chemical Engineering Journal.2022; 442: 136273. CrossRef
Modeling the Succinic Acid Bioprocess: A Review
Itziar A. Escanciano, Mateusz Wojtusik, Jesús Esteban, Miguel Ladero, Victoria E. Santos
Fermentation.2022; 8(8): 368. CrossRef
Kinetic modeling of succinate production from glucose and xylose by metabolically engineered Escherichia coli KJ12201
Tassanon Chaleewong, Panwana Khunnonkwao, Channarong Puchongkawarin, Kaemwich Jantama
Biochemical Engineering Journal.2022; 185: 108487. CrossRef
Whole slurry saccharification of mild oxalic acid-pretreated oil palm trunk biomass improves succinic acid production
Nurul Adela Bukhari, Soh Kheang Loh, Abdullah Amru Indera Luthfi, Peer Mohamed Abdul, Abu Bakar Nasrin, Shuhaida Harun, Jamaliah Md Jahim
Industrial Crops and Products.2021; 171: 113854. CrossRef
Continuous Succinic Acid Fermentation by Actinobacillus Succinogenes: Assessment of Growth and Succinic Acid Production Kinetics
Mariateresa Ferone, Francesca Raganati, Giuseppe Olivieri, Piero Salatino, Antonio Marzocchella
Applied Biochemistry and Biotechnology.2019; 187(3): 782. CrossRef
Metabolic engineering of the type I methanotroph Methylomonas sp. DH-1 for production of succinate from methane
Diep Thi Ngoc Nguyen, Ok Kyung Lee, Susila Hadiyati, Azka Nur Affifah, Min Sik Kim, Eun Yeol Lee
Metabolic Engineering.2019; 54: 170. CrossRef
Production of 5-aminolevulinic Acid by Recombinant Streptomyces coelicolor Expressing hemA from Rhodobacter sphaeroides
Nu Thi Tran, Diep Ngoc Pham, Chang-Joon Kim
Biotechnology and Bioprocess Engineering.2019; 24(3): 488. CrossRef
Membrane engineering via trans-unsaturated fatty acids production improves succinic acid production in Mannheimia succiniciproducens
Jung Ho Ahn, Jong An Lee, Junho Bang, Sang Yup Lee
Journal of Industrial Microbiology and Biotechnology.2018; 45(7): 555. CrossRef
Succinic acid production from cheese whey by biofilms of Actinobacillus succinogenes: packed bed bioreactor tests
Luca Longanesi, Dario Frascari, Cecilia Spagni, Heleen DeWever, Davide Pinelli
Journal of Chemical Technology & Biotechnology.2018; 93(1): 246. CrossRef
Improvement of succinate production by release of end-product inhibition in Corynebacterium glutamicum
Soon-Chun Chung, Joon-Song Park, Jiae Yun, Jin Hwan Park
Metabolic Engineering.2017; 40: 157. CrossRef
Modelling succinic acid fermentation using a xylose based substrate
Chrysanthi Pateraki, Henrik Almqvist, Dimitris Ladakis, Gunnar Lidén, Apostolis A. Koutinas, Anestis Vlysidis
Biochemical Engineering Journal.2016; 114: 26. CrossRef
Continuous succinic acid production by Actinobacillus succinogenes on xylose-enriched hydrolysate
Michael F. A. Bradfield, Ali Mohagheghi, Davinia Salvachúa, Holly Smith, Brenna A. Black, Nancy Dowe, Gregg T. Beckham, Willie Nicol
Biotechnology for Biofuels.2015;[Epub] CrossRef
Continuous succinic acid fermentation by Escherichia coli KJ122 with cell recycle
Adolf Krige, Willie Nicol
Process Biochemistry.2015; 50(12): 2004. CrossRef
Economically enhanced succinic acid fermentation from cassava bagasse hydrolysate using Corynebacterium glutamicum immobilized in porous polyurethane filler
Xinchi Shi, Yong Chen, Hengfei Ren, Dong Liu, Ting Zhao, Nan Zhao, Hanjie Ying
Bioresource Technology.2014; 174: 190. CrossRef
Succinic acid production from sucrose by Actinobacillus succinogenes NJ113
Min Jiang, Wenyu Dai, Yonglan Xi, Mingke Wu, Xiangping Kong, Jiangfeng Ma, Min Zhang, Kequan Chen, Ping Wei
Bioresource Technology.2014; 153: 327. CrossRef
Succinic acid production with Actinobacillus succinogenes: rate and yield analysis of chemostat and biofilm cultures
Hendrik Gideon Brink, Willie Nicol
Microbial Cell Factories.2014;[Epub] CrossRef
Novel membrane-based biotechnological alternative process for succinic acid production and chemical synthesis of bio-based poly (butylene succinate)
Caixia Wang, Wei Ming, Daojiang Yan, Congcong Zhang, Maohua Yang, Yilan Liu, Yu Zhang, Baohua Guo, Yinhua Wan, Jianmin Xing
Bioresource Technology.2014; 156: 6. CrossRef
Improving the lactic acid production of Actinobacillus succinogenes by using a novel fermentation and separation integration system
Caixia Wang, Qiang Li, Dan Wang, Jianmin Xing
Process Biochemistry.2014; 49(8): 1245. CrossRef
Dynamic strain scanning optimization: an efficient strain design strategy for balanced yield, titer, and productivity. DySScO strategy for strain design
Kai Zhuang, Laurence Yang, William R Cluett, Radhakrishnan Mahadevan
BMC Biotechnology.2013;[Epub] CrossRef
Improved Succinate Production by Metabolic Engineering
Ke-Ke Cheng, Gen-Yu Wang, Jing Zeng, Jian-An Zhang
BioMed Research International.2013; 2013: 1. CrossRef
Biotechnological production of succinic acid: current state and perspectives
Ke‐Ke Cheng, Xue‐Bing Zhao, Jing Zeng, Jian‐An Zhang
Biofuels, Bioproducts and Biorefining.2012; 6(3): 302. CrossRef
Wheat‐based biorefining strategy for fermentative production and chemical transformations of succinic acid
Carol S. K. Lin, Rafael Luque, James H. Clark, Colin Webb, Chenyu Du
Biofuels, Bioproducts and Biorefining.2012; 6(1): 88. CrossRef
Influence of Osmotic Stress on Fermentative Production of Succinic Acid by Actinobacillus succinogenes
Xiaojiang Fang, Jian Li, Xiaoyu Zheng, Yonglan Xi, Kequan Chen, Ping Wei, Ping-Kai Ouyang, Min Jiang
Applied Biochemistry and Biotechnology.2011; 165(1): 138. CrossRef
Influence of Solvent Polarity on the Mechanism and Efficiency of Formic Acid Reactive Extraction with Tri‐n‐Octylamine from Aqueous Solutions
A.‐I. Galaction, L. Kloetzer, D. Cascaval
Chemical Engineering & Technology.2011; 34(8): 1341. CrossRef
Process development of succinic acid production by Escherichia coli NZN111 using acetate as an aerobic carbon source
Yuan Liu, Hui Wu, Qing Li, Xuwei Tang, Zhimin Li, Qin Ye
Enzyme and Microbial Technology.2011; 49(5): 459. CrossRef
Influence of Organic Phase Polarity on Interfacial Mechanism and Efficiency of Reactive Extraction of Acetic Acid with Tri-n-octylamine
Dan Caşcaval, Lenuţa Kloetzer, Anca-Irina Galaction
Journal of Chemical & Engineering Data.2011; 56(5): 2521. CrossRef
High cell density fermentation via a metabolically engineered Escherichia coli for the enhanced production of succinic acid
Dan Wang, Qiang Li, Ziyu Song, Wei Zhou, Zhiguo Su, Jianmin Xing
Journal of Chemical Technology & Biotechnology.2011; 86(4): 512. CrossRef

First
Prev
Page of 1
Next
Last

Search