Antimicrobial peptides (AMPs) are small molecules with a
broad spectrum of antibiotic activities against bacteria, yeasts,
fungi, and viruses and cytotoxic activity on cancer cells, in
addition to anti-inflammatory and immunomodulatory activities.
Therefore, AMPs have garnered interest as novel therapeutic
agents. Because of the rapid increase in drug-resistant
pathogenic microorganisms, AMPs from synthetic and
natural sources have been developed using alternative antimicrobial
strategies. This article presents a broad analysis of
patents referring to the therapeutic applications of AMPs since
2009. The review focuses on the universal trends in the effective
design, mechanism, and biological evolution of AMPs.
Detection of antibacterial peptides in artisanal rennet and evaluation of their antibacterial activity Angela Michela Immacolata Montone, Sara Elsa Aita, Federico Capuano, Angelo Citro, Alessandra Esposito, Alfonso Gallo, Morena Nappa, Enrico Taglioni, Carmela Maria Montone International Dairy Journal.2025; 160: 106074. CrossRef
Chiral nanosystem and chiral supraparticles for drug delivery: an expert opinion Mahfoozur Rahman, Janhvi Singh, Alhussain Aodah, Majed Alrobaian, Nabil K Alruwaili, Waleed H Almalki, Salem Salman Almujri, Safia Obaidur Rab, Osama A. Madkhali, Ankit Sahoo, Jonathan A Lal Expert Opinion on Drug Delivery.2025; 22(2): 143. CrossRef
Zeolitic imidazolium framework (ZIF-8) and their derivative-based material for antibacterial study: a comprehensive review Asima Subhadarshini, Binita Nanda Discover Materials.2025;[Epub] CrossRef
Comprehensive exploration of programmed cell death landscape in lung adenocarcinoma combining multi-omic analysis and experimental verification Peng Yu, Leyang Xiao, Kaibo Hu, Jitao Ling, Yixuan Chen, Ruiqi Liang, Xinyu Liu, Deju Zhang, Yuzhen Liu, Tongchun Weng, Hongfa Jiang, Jing Zhang, Wuming Wang Scientific Reports.2025;[Epub] CrossRef
Unfolding the Potential of Pyrrole- and Indole-Based Allylidene Hydrazine Carboximidamides as Antimicrobial Agents Amit Sharma, Sonali J. Jain, Prabhat Nath Jha, Santosh Rudrawar, Sandip B. Bharate, Hemant R. Jadhav ACS Infectious Diseases.2025; 11(2): 493. CrossRef
Exploring the potential of anticancer peptides as therapeutic agents for cancer treatment Reza Ghavimi, Samira Mahmoudi, Mohsen Mohammadi, Elahe Khodamoradi, Ali Jahanian-Najafabadi Research in Pharmaceutical Sciences.2025; 20(2): 165. CrossRef
Role of Milk-Derived Antimicrobial Peptides and their Future Perspectives in Pharmaceutical/ Dairy Industries Venkateshwaran Krishnaswami, Selvakumar Muruganantham, Jacob Raja, Subhashini K Sripathi Current Functional Foods.2025;[Epub] CrossRef
Nano-enhanced peptides: bridging cutting-edge tech and biology to
outsmart resilient microbes Anurag Yadav, Kusum Yadav Academia Nano: Science, Materials, Technology.2025;[Epub] CrossRef
The effect of C-terminal deamidation on bacterial susceptibility and resistance to modelin-5 Sarah R. Dennison, Leslie H. G. Morton, Kamal Badiani, Frederick Harris, David A. Phoenix European Biophysics Journal.2025; 54(1-2): 45. CrossRef
Production, Delivery, and Regulatory Aspects for Application of Plant-Based Anti-microbial Peptides: a Comprehensive Review Praveen Nagella, Balamuralikrishnan Balasubramanian, Sungkwon Park, Udisha Singh, Arpita Jayan, Saptadeepa Mukherjee, Aatika Nizam, Arun Meyyazhagan, Manikantan Pappuswamy, Joseph Kadanthottu Sebastian, Vasantha Veerappa Lakshmaiah, Amin Mousavi Khaneghah Probiotics and Antimicrobial Proteins.2025;[Epub] CrossRef
Effect of Chirality and Amphiphilicity on the Antimicrobial Activity of Tripodal Lysine-Based Peptides Anindyasundar Adak, Valeria Castelletto, Lucas de Mello, Bruno Mendes, Glyn Barrett, Jani Seitsonen, Ian W. Hamley ACS Applied Bio Materials.2025; 8(1): 803. CrossRef
Recent advances, strategies, and future perspectives of peptide-based drugs in clinical applications Qimeng Yang, Zhipeng Hu, Hongyu Jiang, Jialing Wang, Han Han, Wei Shi, Hai Qian Chinese Journal of Natural Medicines.2025; 23(1): 31. CrossRef
Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines Wenjing Xiao, Wenjie Jiang, Zheng Chen, Yu Huang, Junyi Mao, Wei Zheng, Yonghe Hu, Jianyou Shi Signal Transduction and Targeted Therapy.2025;[Epub] CrossRef
Small peptides from non-edible fish waste with antimicrobial activity Benjamaporn Wonganu, Sittiruk Roytrakul, P. Jearanaisilawong, P. Srisungsitthisunti E3S Web of Conferences.2025; 602: 02004. CrossRef
Green approaches for biofilm eradication: Enhancing cleaning efficiency Samah Mechmechani, Piyush Kumar Jha, Layal Karam, Heni Dallagi Journal of Food Safety.2024;[Epub] CrossRef
Combined release of LL37 peptide and zinc ion from a mussel-inspired coating on porous titanium for infected bone defect repairing Yanni Zhang, Na Sun, Fangfang Hu, Wenhui Zhang, Qian Gao, Que Bai, Caiyun Zheng, Qiang Chen, Yong Han, Tingli Lu Colloids and Surfaces B: Biointerfaces.2024; 244: 114181. CrossRef
Engineering Short Antimicrobial Peptides to Specifically Target Fusobacterium nucleatum in the Mixed Microbial Population Zhao Liu, Yijie Wang, Chen Zhang, Yongshuai Yang, Junfeng Zhang ACS Infectious Diseases.2024; 10(8): 3042. CrossRef
Novel non-helical antimicrobial peptides insert into and fuse lipid model membranes Saheli Mitra, Bhairavi Chandersekhar, Yunshu Li, Mark Coopershlyak, Margot E. Mahoney, Brandt Evans, Rachel Koenig, Stephen C. L. Hall, Beate Klösgen, Frank Heinrich, Berthony Deslouches, Stephanie Tristram-Nagle Soft Matter.2024; 20(20): 4088. CrossRef
Molecular characterization, antibacterial and immunoregulatory activities of liver-expressed antimicrobial peptide 2 in black rockfish, Sebastes schlegelii Min Zhang, Xue Yan, Chang-biao Wang, Wen-qing Liu, Yue Wang, Hao Jing, Bing Wang, Kai Yang, Zi-yue Chen, Yu-yu Luan, Guang-hua Wang Fish & Shellfish Immunology.2024; 147: 109467. CrossRef
Local Drug Delivery Systems as Novel Approach for Controlling NETosis in Periodontitis Adina Bianca Boșca, Elena Dinte, Carmen Mihaela Mihu, Alina Elena Pârvu, Carmen Stanca Melincovici, Alina Simona Șovrea, Mariana Mărginean, Anne-Marie Constantin, Anida-Maria Băbțan, Alexandrina Muntean, Aranka Ilea Pharmaceutics.2024; 16(9): 1175. CrossRef
Converging frontiers in cancer treatment: the role of nanomaterials, mesenchymal stem cells, and microbial agents—challenges and limitations Hamed Afkhami, Aref Yarahmadi, Shoroq Bostani, Nahid Yarian, Mahdieh Sadat Haddad, Shima Sadat Lesani, Seyed Soheil Aghaei, Mohammad Reza Zolfaghari Discover Oncology.2024;[Epub] CrossRef
Efficacy of a mouthwash containing ε-poly-L-lysine, funme peptides and domiphen in reducing halitosis and supragingival plaque: a randomized clinical trial Song Shen, Xu Liu, Jun Huang, Yi Sun, Bin Liu, Wenzhu Song, Lei Meng, Mi Du, Qiang Feng BMC Oral Health.2024;[Epub] CrossRef
Rational Design of Amphipathic Antimicrobial Peptides with Alternating L-/D-Amino Acids That Form Helical Structures Motoharu Hirano, Hidetomo Yokoo, Nobumichi Ohoka, Takahito Ito, Takashi Misawa, Makoto Oba, Takao Inoue, Yosuke Demizu Chemical and Pharmaceutical Bulletin.2024; 72(2): 149. CrossRef
Synthetic Antimicrobial Peptides Fail to Induce Leucocyte Innate Immune Functions but Elicit Opposing Transcriptomic Profiles in European Sea Bass and Gilthead Seabream Laura Cervera, Elena Chaves-Pozo, Alberto Cuesta Marine Drugs.2024; 22(2): 86. CrossRef
Three hepcidins from the spotted knifejaw (Oplegnathus punctatus) promote antimicrobial activity via TLR/NFκB pathway Jie Wang, Yadong Chen, Yu Song, Wenteng Xu, Wensheng Li, Wenhui Ma, Chuanjun Yang, Zhangfan Chen, Songlin Chen Fish & Shellfish Immunology.2024; 154: 109958. CrossRef
Combating antibiotic resistance in a one health context: a plethora of frontiers Daniel Jesuwenu Ajose, Abimbola Olumide Adekanmbi, Nor Fadhilah Kamaruzzaman, Collins Njie Ateba, Shamsaldeen Ibrahim Saeed One Health Outlook.2024;[Epub] CrossRef
A review on Diversity, Mechanism of Action and Evolutionary Significance of Antimicrobial Peptides Noor Muhammad, Waiza Ansar, Arif Ullah, Iram Liaqat, Zahid Nazir Futuristic Biotechnology.2024; : 02. CrossRef
Protective effects of Chinese bayberry pomace wine against oxidative stress on Drosophila melanogaster Yanyun Zhu, Mengting Wang, Jingjing Zhu, Xiayin Zhang, Xingqian Ye, Jianchu Chen Food Research International.2024; 194: 114885. CrossRef
In silico and physico-chemical characterization of cluster formation dynamics in peptide solutions Dimitar Kaynarov, Karina Marinova, Rossitsa Marinova, Peicho Petkov, Lyudmila Velkova, Aleksandar Dolashki, Petar Petrov, Leandar Litov, Elena Lilkova, Pavlina Dolashka, Nevena Ilieva Biochemistry and Biophysics Reports.2024; 39: 101753. CrossRef
Chensinin-1b Alleviates DSS-Induced Inflammatory Bowel Disease by Inducing Macrophage Switching from the M1 to the M2 Phenotype Yue Sun, Huiyu Li, Xingpeng Duan, Xiaoxiao Ma, Chenxi Liu, Dejing Shang Biomedicines.2024; 12(2): 345. CrossRef
Oral administration of anti-lipopolysaccharide factor isoform 3 via the bait microalga for controlling bacterial infection of Atlantic Bay scallop (Argopecten irradians) Yulin Cui, Ping Liu, Yaping Shao, Fengjie Sun, Qiaolei Wang, Hao Zhang, Yan Cheng, Zhengquan Gao Aquaculture Reports.2024; 39: 102430. CrossRef
Mechanistic insights on the antibiofilm potential of snake venom peptides: An in silico based molecular docking approach Moupriya Nag Biocatalysis and Agricultural Biotechnology.2024; 61: 103351. CrossRef
Antimicrobial Peptides and Their Biomedical Applications: A Review Ki Ha Min, Koung Hee Kim, Mi-Ran Ki, Seung Pil Pack Antibiotics.2024; 13(9): 794. CrossRef
Nano-strategies used for combatting the scourge of tuberculosis infections Ren Fang, Yubao Jin, Weihao Kong, Hui Wang, Shuxian Wang, Xiaotian Li, Jiayin Xing, Yumiao Zhang, Xingyue Yang, Ningning Song Discover Immunity.2024;[Epub] CrossRef
Antimicrobial Peptide Screening for Designing Custom Bactericidal Hydrogels Matthias Recktenwald, Muskanjot Kaur, Mohammed M. Benmassaoud, Aryanna Copling, Tulika Khanna, Michael Curry, Dennise Cortes, Gilbert Fleischer, Valerie J. Carabetta, Sebastián L. Vega Pharmaceutics.2024; 16(7): 860. CrossRef
Hepcidin and dicentracin peptides show preventive antiviral applications against NNV infection in European sea bass through immunomodulatory roles Laura Cervera, Marta Arizcun, Luis Mercado, Elena Chaves-Pozo, Alberto Cuesta Aquaculture.2024; 583: 740592. CrossRef
Natural Antimicrobial Peptides and Their Synthetic Analogues for Effective Oral Microflora Control and Oral Infection Treatment—The Role of Ceragenins in the Development of New Therapeutic Methods Michał Czarnowski, Urszula Wnorowska, Milena Łuckiewicz, Ewelina Dargiewicz, Jakub Spałek, Sławomir Okła, Beata Sawczuk, Paul B. Savage, Robert Bucki, Ewelina Piktel Pharmaceuticals.2024; 17(12): 1725. CrossRef
A Novel Beta-Defensin Isoform from Malabar Trevally, Carangoides malabaricus (Bloch & Schneider, 1801), an Arsenal Against Fish Bacterial Pathogens: Molecular Characterization, Recombinant Production, and Mechanism of Action Athira P. P., Anju M. V., Anooja V. V., Archana K., Neelima S., Muhammed Musthafa S., I. S. Bright Singh, Rosamma Philip Marine Biotechnology.2024; 26(4): 696. CrossRef
Daidzein‐Based Amphiphilic Small Molecular Antimicrobial Peptidomimetics as Novel Antimicrobial Agents with Anti‐Biofilm Activity Zijian Hong, Tsz Tin Yu, Muhammad Yasir, Manjulatha Sara, David StC Black, Mark DP Willcox, Rajesh Kuppusamy, Naresh Kumar ChemistrySelect.2024;[Epub] CrossRef
Development strategies and application of antimicrobial peptides as future alternatives to in-feed antibiotics Qingping Liang, Zhemin Liu, Ziyu Liang, Changliang Zhu, Dongyu Li, Qing Kong, Haijin Mou Science of The Total Environment.2024; 927: 172150. CrossRef
Functional interplay between short antimicrobial peptides and model lipid membranes Lorena Gratino, Marta Gogliettino, Marco Balestrieri, Alessandra Porritiello, Principia Dardano, Bruno Miranda, Rosa Luisa Ambrosio, Monica Ambrosio, Luigi Nicolais, Gianna Palmieri Bioorganic Chemistry.2024; 153: 107939. CrossRef
Improving Photocleavage Efficiency of Photocleavable Protein for
Antimicrobial Peptide Histatin 1 Expression Nana Zhou, Tai An, Yuan Zhang, Guomiao Zhao, Chao Wei, Xuemei Shen, Fan Li, Xiaoyan Wang Protein & Peptide Letters.2024; 31(2): 141. CrossRef
In silico
approach revealed the membrane receptor PHO36 as a new target for synthetic anticandidal peptides
Francisco ES Lopes, Pedro FN Souza, Daiane MS Brito, Felipe P Mesquita, Raquel C Montenegro, Jackson L Amaral, José HA Filho, Valder N Freire, Rossana A Cordeiro Future Microbiology.2024; 19(17): 1463. CrossRef
Interaction of designed cationic antimicrobial peptides with the outer membrane of gram-negative bacteria Shelley He, Charles M. Deber Scientific Reports.2024;[Epub] CrossRef
Artificial Intelligence-Based Model for Predicting the Minimum Inhibitory Concentration of Antibacterial Peptides Against ESKAPEE Pathogens Ritesh Sharma, Sameer Shrivastava, Sanjay Kumar Singh, Abhinav Kumar, Amit Kumar Singh, Sonal Saxena IEEE Journal of Biomedical and Health Informatics.2024; 28(4): 1949. CrossRef
Synergistic peptide combinations designed to suppress SARS-CoV-2 Tao Han, Linhong Song, Xinxin Niu, Meng Qiu, Yi Wang, Jing Wang, Xiuyan Sun, Jiali Ma, Siqi Hu, Zhichun Feng Heliyon.2024; 10(9): e30489. CrossRef
Synthesis and Biological Studies of New Temporin A Analogs Containing Unnatural Amino Acids in Position 7 Dilyana Dimitrova, Veronica Nemska, Tsvetelina Foteva, Ivan Iliev, Nelly Georgieva, Dancho Danalev Pharmaceutics.2024; 16(6): 716. CrossRef
PACAP sequence modifications modulate the peptide antimicrobial activity against bacterial pathogens affecting aquaculture Laura Rivera Méndez, Tania Rodríguez-Cornejo, Tania Rodríguez-Ramos, Lowia Al-Hussinee, Janet Velázquez, James Hugh Campbell, Yamila Carpio, Mario Pablo Estrada, Brian Dixon Fish & Shellfish Immunology.2024; 148: 109512. CrossRef
Antimicrobial and immunomodulatory activities of porcine cathelicidin Protegrin-1 Ali Javed, Trishana Oedairadjsingh, Irene S. Ludwig, Thomas M. Wood, Nathaniel I. Martin, Femke Broere, Markus H. Weingarth, Edwin J.A. Veldhuizen Molecular Immunology.2024; 173: 100. CrossRef
Antimicrobial Peptides: Sources, Expression Systems, and Applications Mengru Li, Weitao Lu, Yanyan Sun, Chunming Dong Current Protein & Peptide Science.2023; 24(8): 640. CrossRef
Operative Management of Burns: Traditional Care David G. Greenhalgh European Burn Journal.2023; 4(2): 262. CrossRef
Antimicrobial Peptides Noorul Samsoon Maharifa Haja Mohaideen, S. Vaani, S. Hemalatha Current Pharmacology Reports.2023; 9(6): 433. CrossRef
Advances in Research on Titanium and Titanium Alloys with Antibacterial Functionality for Medical Use—A Review Yong Shen, Zhankui Jin, Ming Ling, Zhengming Sun, Min Feng, Cuixiang Xu, Shizhang Liu Journal of Biomaterials and Tissue Engineering.2023; 13(1): 1. CrossRef
An active domain SA-2 derived from cystatin-SA, and its antifungal activity Xiaoyun Liu, Xiaowei Huang, Jian Wang, Meina Zhang, Mengyuan Liu, Changlin Zhou, Lingman Ma Amino Acids.2023; 55(1): 101. CrossRef
Diversity of Bioinspired Hydrogels: From Structure to Applications Alexandra Lupu, Luiza Madalina Gradinaru, Vasile Robert Gradinaru, Maria Bercea Gels.2023; 9(5): 376. CrossRef
Bioactive peptides derived from fermented foods: Preparation and biological activities Qingyan Guo, Pengfei Chen, Xianggui Chen Journal of Functional Foods.2023; 101: 105422. CrossRef
Anti-microbial Peptides against Methicillin-resistant Staphylococcus
aureus: Promising Therapeutics Priyanka Sinoliya, Pooran Singh Solanki, Sakshi Piplani, Ravi Ranjan Kumar Niraj, Vinay Sharma Current Protein & Peptide Science.2023; 24(2): 156. CrossRef
Natural and synthetic peptides in antimicrobial therapy Karina A. Khlystova, Narine G. Sarkisyan, Natalia N. Kataeva Russian Journal of Immunology.2023; 26(2): 105. CrossRef
Biomimetic antimicrobial polymers—Design, characterization, antimicrobial, and novel applications Haruko Takahashi, Iva Sovadinova, Kazuma Yasuhara, Satyavani Vemparala, Gregory A. Caputo, Kenichi Kuroda WIREs Nanomedicine and Nanobiotechnology.2023;[Epub] CrossRef
Antimicrobial peptides: Structure, mechanism, and modification Na Chen, Cheng Jiang European Journal of Medicinal Chemistry.2023; 255: 115377. CrossRef
Repairing the intestinal mucosal barrier of traditional Chinese medicine for ulcerative colitis: a review Yichen Zong, Jie Meng, Tangyou Mao, Qiang Han, Peng Zhang, Lei Shi Frontiers in Pharmacology.2023;[Epub] CrossRef
Advancements, challenges and future perspectives on peptide-based drugs: Focus on antimicrobial peptides Xiaofang Luo, Huifang Chen, Yannan Song, Zuodong Qin, Lijian Xu, Nongyue He, Yimin Tan, Wubliker Dessie European Journal of Pharmaceutical Sciences.2023; 181: 106363. CrossRef
Therapeutic Prospection of Animal Venoms-Derived Antimicrobial Peptides against Infections by Multidrug-Resistant Acinetobacter baumannii: A Systematic Review of Pre-Clinical Studies William Gustavo Lima, Maria Elena de Lima Toxins.2023; 15(4): 268. CrossRef
Antimicrobial Efficacy and Prevalence of Microcins: Low Molecular Mass Bacteriocins Produced by Escherichia coli Farzaneh Mohammadzadeh Rostami, Sharareh Moghim, Saeid Javdan, Bahram Nasr Esfahani International Journal of Peptide Research and Therapeutics.2023;[Epub] CrossRef
Chiral-engineered supraparticles: Emerging tools for drug delivery Mahfoozur Rahman, Waleed H. Almalki, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Shehla Nasar Mir Najib Ullah, Md. Abul Barkat, Sarwar Beg Drug Discovery Today.2023; 28(1): 103420. CrossRef
In Vitro Biological Evaluation and Mechanism of Action of Peptoid Analogue Based on Cationic, Amphipathic Peptide A-12 Lalita Sharma, Gopal Singh Bisht International Journal of Peptide Research and Therapeutics.2023;[Epub] CrossRef
Recombinant production of human antimicrobial peptide LL- 37 and its secondary structure Antonín Pavelka, Lukáš Vacek, Adam Norek, Šárka Kobzová, Lubomír Janda Biologia.2023; 79(1): 263. CrossRef
Synergistic Effect, Improved Cell Selectivity, and Elucidating the Action Mechanism of Antimicrobial Peptide YS12 Suzia Aktar Suchi, Dae Young Lee, Young Kyun Kim, Seong Soo Kang, Tahmina Bilkis, Jin Cheol Yoo International Journal of Molecular Sciences.2023; 24(17): 13522. CrossRef
Dual-action potential of cationic cryptides against infections and cancers Amr A.A. Abd El-Aal, Fairen A. Jayakumar, Kavita Reginald Drug Discovery Today.2023; 28(11): 103764. CrossRef
Natural Amphibian-Derived Host Defense Peptides: Peptide Immunomodulators
with Potential Therapeutic Value Jie Shi, Jing Wu, Guizhu Feng, Hailong Yang, Lixian Mu Protein & Peptide Letters.2023; 30(7): 562. CrossRef
Self-assembled and Zn(II)-coordinated dipeptide nanoparticles with membrane-rupturing action on bacteria Shahzad Anwar, Muhammad Babar Khawar, Ali Afzal, Muhammad Ovais, Zhang Xiang Applied Microbiology and Biotechnology.2023; 107(18): 5775. CrossRef
Therapeutic Peptides for Treatment of Lung Diseases: Infection, Fibrosis, and Cancer Shujiao Li, Yuying Li, Ying Liu, Yifan Wu, Qiuyu Wang, Lili Jin, Dianbao Zhang International Journal of Molecular Sciences.2023; 24(10): 8642. CrossRef
The biological role of charge distribution in linear antimicrobial peptides Harry Morales Duque, Gisele Rodrigues, Lucas Souza Santos, Octávio Luiz Franco Expert Opinion on Drug Discovery.2023; 18(3): 287. CrossRef
Colitis-Mediated Dysbiosis of the Intestinal Flora and Impaired Vitamin A Absorption Reduce Ovarian Function in Mice Ze Li, Chengzhen Chen, Wenjie Yu, Lingxia Xu, Haitao Jia, Chen Wang, Na Pei, Zibin Liu, Dan Luo, Jun Wang, Wenfa Lv, Bao Yuan, Jiabao Zhang, Hao Jiang Nutrients.2023; 15(11): 2425. CrossRef
Insect Meals and Insect Antimicrobial Peptides as an Alternative for Antibiotics and Growth Promoters in Livestock Production Ewelina Patyra, Krzysztof Kwiatek Pathogens.2023; 12(6): 854. CrossRef
Simultaneous control of infection and inflammation with keratin-derived antibacterial peptides targeting TLRs and co-receptors Yan Sun, Jonathan Chan, Karthikeyan Bose, Connie Tam Science Translational Medicine.2023;[Epub] CrossRef
Structural Characterization, Functional Profiling, and Mechanism Study of Four Antimicrobial Peptides for Antibacterial and Anticancer Applications Zihuayuan Yang, Jie Zhang, Fu-Gen Wu, Fengming Lin Langmuir.2023; 39(6): 2161. CrossRef
Enhancement of hypericin nanoparticle-mediated sonoinduced disruption of biofilm and persister cells of Streptococcus mutans by dermcidin-derived peptide DCD-1L Maryam Pourhajibagher, Steven Parker, Babak Pourakbari, Nasrin Keshavarz Valian, Reza Raoofian, Abbas Bahador Photodiagnosis and Photodynamic Therapy.2023; 41: 103308. CrossRef
Biomimetic AgNPs@antimicrobial peptide/silk fibroin coating for infection-trigger antibacterial capability and enhanced osseointegration Wenhao Zhou, Tian Bai, Lan Wang, Yan Cheng, Dandan Xia, Sen Yu, Yufeng Zheng Bioactive Materials.2023; 20: 64. CrossRef
Preparation, Purification and Characterization of Antibacterial and ACE Inhibitory Peptides from Head Protein Hydrolysate of Kuruma Shrimp, Marsupenaeus japonicus Jie Zhou, Qiuyu Han, Tomoyuki Koyama, Shoichiro Ishizaki Molecules.2023; 28(2): 894. CrossRef
Brevicillin, a novel lanthipeptide from the genusBrevibacilluswith antimicrobial, antifungal, and antiviral activity Shelley Sardul Singh, Deepika Sharma, Charandeep Singh, Sahil Kumar, Prashant Singh, Anshul Sharma, Deepjyoti Kumar Das, Anil Kumar Pinnaka, Krishan Gopal Thakur, Rajesh P Ringe, Suresh Korpole Journal of Applied Microbiology.2023;[Epub] CrossRef
Fungicidal activity of human antimicrobial peptides and their synergistic interaction with common antifungals against multidrug-resistant Candida auris Siham Shaban, Mrudula Patel, Aijaz Ahmad International Microbiology.2022; 26(2): 165. CrossRef
Aptamer Decorated Emodin Nanoparticles-Assisted Delivery of Dermcidin-Derived Peptide DCD-1L: Photoactive Bio-Theragnostic Agent for Enterococcus Faecalis Biofilm Destruction Maryam Pourhajibagher, Abbas Bahador SSRN Electronic Journal .2022;[Epub] CrossRef
Aptamer decorated emodin nanoparticles-assisted delivery of dermcidin-derived peptide DCD-1L: Photoactive bio-theragnostic agent for Enterococcus faecalis biofilm destruction Maryam Pourhajibagher, Abbas Bahador Photodiagnosis and Photodynamic Therapy.2022; 39: 103020. CrossRef
Production of Antimicrobial Peptides (Cathelicidin Analogues) and Evaluation of Their Biological Properties V. A. Gasanov, E. A. Vorotelyak, A. V. Vasiliev Biology Bulletin.2022; 49(S2): S148. CrossRef
Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics Jayaseelan Murugaiyan, P. Anand Kumar, G. Srinivasa Rao, Katia Iskandar, Stephen Hawser, John P. Hays, Yara Mohsen, Saranya Adukkadukkam, Wireko Andrew Awuah, Ruiz Alvarez Maria Jose, Nanono Sylvia, Esther Patience Nansubuga, Bruno Tilocca, Paola Roncada, Antibiotics.2022; 11(2): 200. CrossRef
Strategies for improving antimicrobial peptide production Soumya Deo, Kristi L. Turton, Tajinder Kainth, Ayush Kumar, Hans-Joachim Wieden Biotechnology Advances.2022; 59: 107968. CrossRef
Riemerella anatipestifer T9SS Effector SspA Functions in Bacterial Virulence and Defending Natural Host Immunity Zongchao Chen, Pengfei Niu, Xiaomei Ren, Wenlong Han, Ruyu Shen, Min Zhu, Yang Yu, Chan Ding, Shengqing Yu, Martha Vives Applied and Environmental Microbiology.2022;[Epub] CrossRef
Antibacterial and Antibiofilm Activities of Novel Cyclic Peptides against Methicillin-Resistant Staphylococcus aureus Guoxing Wei, Yun He International Journal of Molecular Sciences.2022; 23(14): 8029. CrossRef
Effect of Flagellin Pre-Exposure on the Inflammatory and Antifungal Response of Bronchial Epithelial Cells to Fungal Pathogens Jeanne Bigot, Manon Ruffin, Juliette Guitard, Sandra Vellaissamy, Sophie Thorez, Harriet Corvol, Loïc Guillot, Viviane Balloy, Christophe Hennequin Journal of Fungi.2022; 8(12): 1268. CrossRef
Gold nanoparticle-DNA aptamer-assisted delivery of antimicrobial peptide effectively inhibits Acinetobacter baumannii infection in mice Jaeyeong Park, Eunkyoung Shin, Ji-Hyun Yeom, Younkyung Choi, Minju Joo, Minho Lee, Je Hyeong Kim, Jeehyeon Bae, Kangseok Lee Journal of Microbiology.2022; 60(1): 128. CrossRef
Antimicrobial peptides (AMPs): A promising class of antimicrobial compounds Mine Erdem Büyükkiraz, Zülal Kesmen Journal of Applied Microbiology.2022; 132(3): 1573. CrossRef
Novel Insights into Fungal Infections Prophylaxis and Treatment in Pediatric Patients with Cancer Gianluca Bossù, Riccardo Di Sario, Edoardo Muratore, Davide Leardini, Andrea Pession, Susanna Esposito, Riccardo Masetti Antibiotics.2022; 11(10): 1316. CrossRef
Role of lipopolysaccharide in antimicrobial and cell penetrating peptide membrane interactions probed by deuterium NMR of whole cells Sarika Kumari, Michael R. Morrow, Valerie Booth BBA Advances.2022; 2: 100057. CrossRef
Multidrug-Resistant Microbial Therapy Using Antimicrobial Peptides and the CRISPR/Cas9 System Yared Abate Getahun, Destaw Asfaw Ali, Bihonegn Wodajnew Taye, Yismaw Alemie Alemayehu Veterinary Medicine: Research and Reports.2022; Volume 13: 173. CrossRef
Pulmonary surfactant and drug delivery: Vehiculization of a tryptophan-tagged antimicrobial peptide over the air-liquid interfacial highway Cristina García-Mouton, Elisa Parra-Ortiz, Martin Malmsten, Antonio Cruz, Jesús Pérez-Gil European Journal of Pharmaceutics and Biopharmaceutics.2022; 180: 33. CrossRef
Production of antimicrobial peptide arasin-like Sp in Escherichia coli via an ELP-intein self-cleavage system Xiu Li, Yu Jiang, Ying Lin Journal of Biotechnology.2022; 347: 49. CrossRef
Review and perspective on bioactive peptides: A roadmap for research, development, and future opportunities Zhenjiao Du, Yonghui Li Journal of Agriculture and Food Research.2022; 9: 100353. CrossRef
Human Antimicrobial Peptide Triggered Colloidal Transformations in Bacteria Membrane Lipopolysaccharides Linda Hong, Mark Gontsarik, Heinz Amenitsch, Stefan Salentinig Small.2022;[Epub] CrossRef
Combination of Six Individual Derivatives of the Pom-1 Antibiofilm Peptide Doubles Their Efficacy against Invasive and Multi-Resistant Clinical Isolates of the Pathogenic Yeast Candida albicans Michelle Häring, Valerie Amann, Ann-Kathrin Kissmann, Tilmann Herberger, Christopher Synatschke, Nicole Kirsch-Pietz, Julio A. Perez-Erviti, Anselmo J. Otero-Gonzalez, Fidel Morales-Vicente, Jakob Andersson, Tanja Weil, Steffen Stenger, Armando Rodríguez, Pharmaceutics.2022; 14(7): 1332. CrossRef
Pathophysiological Effects of Lycosa erythrognatha Derived Peptide LyeTxI-b on RKO-AS-45-1 Colorectal Carcinoma Cell Line Using the Chicken Chorioallantoic Membrane Model Carolina Nunes da Silva, Lays Fernanda Nunes Dourado, Luciana Maria Silva, Aline Brito de Lima, Maria Elena de Lima, Armando Silva-Cunha, Silvia Ligório Fialho International Journal of Peptide Research and Therapeutics.2022;[Epub] CrossRef
Effect of a monovalent salt on the energetics of an antimicrobial-peptide: micelle dissociation Suvankar Ghosh, Sunanda Chatterjee, Priyadarshi Satpati Physical Chemistry Chemical Physics.2022; 24(38): 23669. CrossRef
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Thirty-nine human isolates of Campylobacter jejuni obtained
from a national university hospital during 2007–2010 and
38 chicken isolates of C. jejuni were collected from poultry
farms during 2009–2010 in South Korea were used in this
study. Campylobacter genomic species and virulence-associated
genes were identified by PCR. Pulsed-field gel electrophoresis
(PFGE) and multilocus sequence typing (MLST)
were performed to compare their genetic relationships. All
isolates were highly resistant to ciprofloxacin, nalidixic acid,
and tetracycline. Of all isolates tested, over 94% contained
seven virulence associated genes (flaA, cadF, racR, dnaJ, cdtA,
cdtB, and cdtC). All isolates were classified into 39 types by
PFGE clustering with 90% similarity. Some chicken isolates
were incorporated into some PFGE types of human isolates.
MLST analysis for the 39 human isolates and 38 chicken isolates result ed in 14 and 23 sequence types (STs), respectively,
of which 10 STs were new. STs overlapped in both chicken
and human isolates included ST-21, ST-48, ST-50, ST-51,
and ST-354, of which ST-21 was the predominant ST in both
human and chicken isolates. Through combined analysis of
PFGE types and STs, three chicken isolates were clonally related
to the three human isolates associated with food poisoning
(VII-ST-48, XXII-ST-354, and XXVIII-ST-51). They
were derived from geographically same or distinct districts.
Remarkably, clonal spread of food poisoning pathogens between
animals and humans was confirmed by population
genetic analysis. Consequently, contamination of campylobacters
with quinolone resistance and potential virulence genes in poultry production and consumption may increase
the risk of infections in humans.
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The gut bacterial community of wood-feeding beetles has
been examined for its role on plant digestion and biocontrol method development. Monochamus alternatus and Psacothea
hilaris, both belonging to the subfamily Lamiinae, are woodfeeding
beetles found in eastern Asia and Europe and generally
considered as destructive pests for pine and mulberry
trees, respectively. However, limited reports exist on the gut
bacterial communities in these species. Here, we characterized
gut bacterial community compositions in larva and imago of
each insect species reared with host tree logs and artificial
diets as food sources. High-throughput 454 pyrosequencing
of bacterial 16S rRNA gene revealed 225 operational taxonomic
units (OTUs) based on a 97% sequences similarity cutoff
from 138,279 sequence reads, the majority of which were
derived from Proteobacteria (48.2%), Firmicutes (45.5%), and
Actinobacteria (5.2%). The OTU network analysis revealed
7 modules with densely connected OTUs in specific gut samples,
in which the distributions of Lactococcus-, Kluyvera-,
Serratia-, and Enterococcus-related OTUs were distinct between
diet types or developmental stages of the host insects.
The gut bacterial communities were separated on a detrended
correspondence analysis (DCA) plot and by c-means fuzzy
clustering analysis, according to diet type. The results from
this study suggest that diet was the main determinant for gut
bacterial community composition in the two beetles.
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Carbon monoxide dehydrogenase (CO-DH) in Mycobacterium
sp. strain JC1 is a key enzyme for the carboxydotrophic
growth, when carbon monoxide (CO) is supplied as a
sole source of carbon and energy. This enzyme is also known
to act as nitric oxide dehydrogenase (NO-DH) for the detoxification
of NO. Several accessory genes such as cutD,
cutE, cutF, cutG, cutH, and cutI, are clustered together with
two copies of the CO-DH structural genes (cutB1C1A1 and
cutB2C2A2) in Mycobacterium sp. strain JC1 and are well
conserved in carboxydotrophic mycobacteria. Transcription
of the CO-DH structural and accessory genes was demonstrated
to be increased significantly by acidified sodium nitrate
as a source of NO. A cutI deletion (ΔcutI) mutant of
Mycobacterium sp. strain JC1 was generated to identity the
function of CutI. Lithoautotrophic growth of the ΔcutI mutant
was severely affected in mineral medium supplemented
with CO, while the mutant grew normally with glucose. Western
blotting, CO-DH activity staining, and CO-DH-specific
enzyme assay revealed a significant decrease in the cellular
level of CO-DH in the ΔcutI mutant. Northern blot analysis
and promoter assay showed that expression of the cutB1
and cutB2 genes was significantly reduced at the transcriptional
level in the ΔcutI mutant, compared to that of the wildtype
strain. The ΔcutI mutant was much more susceptible
to NO than was the wild type.
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RraA is a protein inhibitor of RNase E, which degrades and
processes numerous RNAs in Escherichia coli. Streptomyces
coelicolor also contains homologs of RNase E and RraA,
RNase ES and RraAS1/RraAS2, respectively. Here, we report
that, unlike other RraA homologs, RraAS1 directly interacts
with the catalytic domain of RNase ES to exert its inhibitory
effect. We further show that rraAS1 gene deletion in S. coelicolor results in a higher growth rate and increased production
of actinorhodin and undecylprodigiosin, compared with
the wild-type strain, suggesting that RraAS1-mediated regulation
of RNase ES activity contributes to modulating the
cellular physiology of S. coelicolor.
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Fish pathogen Vibrio anguillarum, a mesophile bacterium,
is usually found in estuarine and marine coastal ecosystems
worldwide that pose a constant stress to local organism by its
fluctuation in salinity as well as notable temperature change.
Though V. anguillarum is able to proliferate while maintain its
pathogenicity under low temperature (5–18°C), so far, coldadaption
molecular mechanism of the bacteria is unknown.
In this study, V. anguillarum was found possessing a putative
glycine betaine synthesis system, which is encoded by betABI
and synthesizes glycine betaine from its precursor choline.
Furthermore, significant up-regulation of the bet gene at the
transcriptional level was noted in log phase in response to
cold-stress. Moreover, the accumulation of betaine glycine
was only found appearing at low growth temperatures, suggesting
that response regulation of both synthesis system
and transporter system are cold-dependent. Furthermore,
in-frame deletion mutation in the two putative ABC transporters
and three putative BCCT family transporters associated
with glycine betaine uptake could not block cellular
accumulation of betaine glycine in V. anguillarum under coldstress,
suggesting the redundant feature in V. anguillarum betaine
transporter system. These findings confirmed that glycine
betaine serves as an effective cold stress protectant and
highlighted an underappreciated facet of the acclimatization
of V. anguillarum to cold environments.
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Novosphingobium pentaromativorans US6-1 is a Gram-negative
halophilic marine bacterium able to utilize several polycyclic
aromatic hydrocarbons such as phenanthrene, pyrene,
and benzo[a]pyrene. In this study, using transmission electron
microscopy, we confirmed that N. pentaromativorans
US6-1 produces outer membrane vesicles (OMVs). N. pentaromativorans
OMVs (hereafter OMVNovo) are spherical in
shape, and the average diameter of OMVNovo is 25–70 nm.
Proteomic analysis revealed that outer membrane proteins
and periplasmic proteins of N. pentaromativorans are the
major protein components of OMVNovo. Comparative proteomic
analysis with the membrane-associated protein fraction
and correlation analysis demonstrated that the outer
membrane proteins of OMVNovo originated from the membrane-
associated protein fraction. To the best of our knowledge,
this study is the first to characterize OMV purified
from halophilic marine bacteria.
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