- Transcriptomic and proteomic profiling revealed global changes in Streptococcus thermophilus during pH-controlled batch fermentations
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Yali Qiao , Cong Leng , Gefei Liu , Yanjiao Zhang , Xuepeng Lv , Hongyu Chen , Jiahui Sun , Zhen Feng
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J. Microbiol. 2019;57(9):769-780. Published online June 14, 2019
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DOI: https://doi.org/10.1007/s12275-019-8604-y
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 Abstract
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Understanding global changes of physiological processes at
the molecular level during the growth of Streptococcus thermophilus
is essential for the rational design of cultivation
media and the optimization of bioprocesses. Transcriptomics
and proteomics were combined to investigate the global
changes at the transcript and protein level during the growth
of S. thermophilus. The expression of 1396 genes (FDR ≤ 0.001)
and 876 proteins (P < 0.05) changed significantly over time.
The most remarkable growth phase dependent changes occurred
in the late-lag phase and were related to heterofermentation,
glycolysis, peptidoglycan biosynthesis, conversion
between amino acids and stress response. The present
results
could provide theoretical guidance for high-cell-density
culture, help design cultivation media, and help attain a
high biomass of S. thermophilus.
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