- Alterations of oral microbiota in Chinese children with viral encephalitis and/or viral meningitis
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Yijie Li , Jing Liu , Yimin Zhu , Chunying Peng , Yao Dong , Lili Liu , Yining He , Guoping Lu , Yingjie Zheng
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J. Microbiol. 2022;60(4):429-437. Published online February 14, 2022
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DOI: https://doi.org/10.1007/s12275-022-1560-y
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 Abstract
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The role of oral microbiota in viral encephalitis and/or viral
meningitis (VEVM) remains unclear. In this hospital-based,
frequency-matched study, children with clinically diagnosed
VEVM (n = 68) and those with other diseases (controls, n =
68) were recruited. Their oral swab samples were collected
and the oral microbiota was profiled using 16S rRNA gene
sequencing. The oral microbiota of children with VEVM exhibited
different beta diversity metrics (unweighted UniFrac
distance: P < 0.001, R2 = 0.025, Bray-curtis dissimilarity: P
= 0.045, R2 = 0.011, and Jaccard dissimilarity: P < 0.001, R2
= 0.017) and higher relative abundances of taxa identified
by Linear discriminant analysis (LDA) with effect size (Enterococcus,
Pedobacter, Massilia, Prevotella_9, Psychrobacter,
Butyricimonas, Bradyrhizobium, etc., LDA scores > 2.0) when
compared with the control group. The higher pathway abundance
of steroid hormone biosynthesis predicted by oral microbiota
was suggested to be linked to VEVM (q = 0.020).
Further, a model based on oral microbial traits showed good
predictive performance for VEVM with an area under the
receiver operating characteristic curve of 0.920 (95% confidence
interval: 0.834–1.000). Similar results were also obtained
between children with etiologically diagnosed VEVM
(n = 43) and controls (n = 68). Our preliminary study identified
VEVM-specific oral microbial traits among children,
which can be effective in the diagnosis of VEVM.
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Citations
Citations to this article as recorded by  - The microbiota-brain connection in neurological diseases: the ubiquitous short-chain fatty acids
Luisa BERTIN, Erica BONAZZI, Sonia FACCHIN, Greta LORENZON, Daria MANIERO, Caterina DE BARBA, Antonietta TOMASULO, Andrea FORTUNA, Fabiana ZINGONE, Brigida BARBERIO, Edoardo V. SAVARINO
Minerva Gastroenterology.2025;[Epub] CrossRef - Metagenomic next-generation sequencing and proteomics analysis in pediatric viral encephalitis and meningitis
Yi-Long Wang, Xiao-Tong Guo, Meng-Ying Zhu, Yu-Chen Mao, Xue-Bin Xu, Yi Hua, Lu Xu, Li-Hua Jiang, Cong-Ying Zhao, Xin Zhang, Guo-Xia Sheng, Pei-Fang Jiang, Zhe-Feng Yuan, Feng Gao
Frontiers in Cellular and Infection Microbiology.2023;[Epub] CrossRef - Bacterial Biomarkers of the Oropharyngeal and Oral Cavity during SARS-CoV-2 Infection
William Bourumeau, Karine Tremblay, Guillaume Jourdan, Catherine Girard, Catherine Laprise
Microorganisms.2023; 11(11): 2703. CrossRef
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