- Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells
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Seulki Lee , Hwan Hee Lee , Jisung Kim , Joohee Jung , Aree Moon , Choon-Sik Jeong , Hyojeung Kang , Hyosun Cho
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J. Microbiol. 2015;53(7):468-474. Published online June 27, 2015
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DOI: https://doi.org/10.1007/s12275-015-5198-x
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Cordyceps extract has been reported to have various pharmacological
activities including an anti-cancer effect. We
investigated the inhibitory effect of Cordyceps militaris on
hepatitis C virus-infected human hepatocarcinoma 7.5 cells
(J6/JFH1-huh 7.5 cells). The huh7.5 cells with or without
HCV infection were treated with various concentrations of
ethanol extract of Cordyceps militaris (CME) for 48 h and the
cytotoxicity was measured by CCK-8 assay. Both J6/JFH1-
huh7.5 cells and huh7.5 cells were highly susceptible to CME.
To examine the molecular mechanisms of the inhibitory effect
on huh7.5 cells, the effect of CME on cell apoptosis was
measured using flow cytometry and the expressions of p53,
Bim, Bax, PARP, (cleaved) caspase-9, and (cleaved) caspase-
3 in huh 7.5 cells were detected by western blot assays. CME
significantly increased early apoptosis and up-regulated the
expression of Bim, Bax, cleaved PARP, cleaved caspase 9
and cleaved caspase-3. We also found the decrease of HCV
Core or NS3 protein by CME in HCV-infected huh 7.5 cells.
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- Genipin as a novel chemical activator of EBV lytic cycle
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Myoungki Son , Minjung Lee , Eunhyun Ryu , Aree Moon , Choon-Sik Jeong , Yong Woo Jung , Gyu Hwan Park , Gi-Ho Sung , Hyosun Cho , Hyojeung Kang
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J. Microbiol. 2015;53(2):155-165. Published online January 28, 2015
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DOI: https://doi.org/10.1007/s12275-015-4672-9
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Epstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus
that causes acute infection and establishes life-long latency.
EBV causes several human cancers, including Burkitt's lymphoma,
nasopharyngeal and gastric carcinoma. Antiviral
agents can be categorized as virucides, antiviral chemotherapeutic
agents, and immunomodulators. Most antiviral agents
affect actively replicating viruses, but not their latent forms.
Novel antiviral agents must be active on both the replicating
and the latent forms of the virus. Gardenia jasminoides is an
evergreen flowering plant belonging to the Rubiaceae family
and is most commonly found growing wild in Vietnam,
Southern China, Taiwan, Japan, Myanmar, and India. Genipin
is an aglycone derived from an iridoid glycoside called geniposide,
which is present in large quantities in the fruit of
G. jasminoides. In this study, genipin was evaluated for its
role as an antitumor and antiviral agent that produces inhibitory
effects against EBV and EBV associated gastric carcinoma
(EBVaGC). In SNU719 cells, one of EBVaGCs, genipin
caused significant cytotoxicity (70 μM), induced methylation
on EBV C promoter and tumor suppressor gene
BCL7A, arrested cell-cycle progress (S phases), upregulated
EBV latent/lytic genes in a dose-dependent manner, stimulated
EBV progeny production, activated EBV F promoter
for EBV lytic activation, and suppressed EBV infection. These
results
indicated that genipin could be a promising candidate
for antiviral and antitumor agents against EBV and
EBVaGC.
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Citations
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