- Composition and abundance of microbiota in the pharynx in patients with laryngeal carcinoma and vocal cord polyps
-
Hongli Gong , Boyan Wang , Yi Shi , Yong Shi , Xiyan Xiao , Pengyu Cao , Lei Tao , Yuezhu Wang , Liang Zhou
-
J. Microbiol. 2017;55(8):648-654. Published online July 28, 2017
-
DOI: https://doi.org/10.1007/s12275-017-6636-8
-
-
917
View
-
1
Download
-
18
Crossref
-
 Abstract
 PDF
-
The pharynx is an important site of microbiota colonization,
but the bacterial populations at this site have been relatively
unexplored by culture-independent approaches. The aim of
this study was to characterize the microbiota structure of the
pharynx. Pyrosequencing of 16S rRNA gene libraries was
used to characterize the pharyngeal microbiota using swab
samples from 68 subjects with laryngeal cancer and 28 subjects
with vocal cord polyps. Overall, the major phylum was
Firmicutes, with Streptococcus as the predominant genus in
the pharyngeal communities. Nine core operational taxonomic
units detected from Streptococcus, Fusobacterium, Prevotella,
Granulicatella, and Veillonella accounted for 21.3%
of the total sequences detected. However, there was no difference
in bacterial communities in the pharynx from patients
with laryngeal cancer and vocal cord polyps. The relative
abundance of Firmicutes was inversely correlated with Fusobacteria,
Proteobacteria, Actinobacteria, and Bacteroidetes.
The correlation was evident at the genus level, and the relative
abundance of Streptococcus was inversely associated with
Fusobacterium, Leptotrichia, Neisseria, Actinomyces, and Prevotella.
This study presented a profile for the overall structure
of the microbiota in pharyngeal swab samples. Inverse correlations
were found between Streptococcus and other bacterial
communities, suggesting that potential antagonism
may exist among pharyngeal microbiota.
-
Citations
Citations to this article as recorded by  - The commensal microbiome in respiratory tract tumors: From oncogenic mechanisms to clinical translation
Jiale Yu, Ciliang Guo, Yan Liu, Xuanqi Ren, Yibo Guo, Beibei Ran, Lingjun Xiao, Lingkai Kong, Xiaosong Gu, Chunping Jiang, Junhua Wu
Journal of Advanced Research.2026;[Epub] CrossRef - Cross-kingdom RNA interference in the dysbiosis-mediated network of vocal fold fibrosis: a pathogenic hypothesis and molecular intervention targets
Quanwei Ren, Yilin Xiang, Di Wu, Yan Bao, Xiaoli Luo, Chao Yu, Yanli Zhao, Xin Zhou
Frontiers in Immunology.2026;[Epub] CrossRef - Evaluating the prognostic value of microbial communities in predicting recurrence of laryngeal carcinoma: a multicenter case-control study
Chi-Yao Hsueh, Xiaohui Yuan, Huiying Huang, Yujie Shen, Qiang Huang, Weida Dong, Danhui Li, Hui-Ching Lau, Xinhui Mao, Simin Liang, Lei Tao, Ming Zhang, Ji Sun, Hongli Gong
npj Biofilms and Microbiomes.2025;[Epub] CrossRef - Dysbiosis Patterns in Glottic and Laryngeal Cancers: A Systematic Review of Microbiome Alterations
Jérôme R. Lechien
Journal of Voice.2025;[Epub] CrossRef - The Role of the Microbiome in Oropharyngeal Squamous Cell Carcinoma: A Systematic Review
Jérôme R. Lechien
Journal of Personalized Medicine.2025; 15(9): 399. CrossRef - Effects of squamous cell carcinoma and smoking status on oropharyngeal and laryngeal microbial communities
Maximilian Oberste, Brit Elisabeth Böse, Luis Gustavo dos Anjos Borges, Howard Junca, Iris Plumeier, Silke Kahl, Frank Simon, Achim Georg Beule, Claudia Rudack, Dietmar H. Pieper
Head & Neck.2024; 46(1): 145. CrossRef - Comparison of the bacterial microbiome in the pharynx and nasal cavity of persistent, intermittent carriers and non-carriers of Staphylococcus aureus
Samuel González-García, Aida Hamdan-Partida, Julia Pérez-Ramos, José Félix Aguirre-Garrido, Anaíd Bustos-Hamdan, Jaime Bustos-Martínez
Journal of Medical Microbiology
.2024;[Epub] CrossRef - Fusobacterium nucleatum impairs DNA mismatch repair and stability in patients with squamous cell carcinoma of the head and neck
Chi‐Yao Hsueh, Hui‐Ching Lau, Qiang Huang, Hongli Gong, Ji Sun, Pengyu Cao, Chunyan Hu, Ming Zhang, Lei Tao, Liang Zhou
Cancer.2022; 128(17): 3170. CrossRef - Raman fl uorescence technologies for early detection of infl ammatory and oncological disorders as a part of public health strategy and a tool for improving the quality of medical care: a review
A. B. Timurzieva
Laser Medicine.2022; 25(4): 42. CrossRef - Cross-comparison of microbiota in the oropharynx, hypopharyngeal squamous cell carcinoma and their adjacent tissues through quantitative microbiome profiling
Hui-Ching Lau, Yujie Shen, Huiying Huang, Xiaohui Yuan, Mengyou Ji, Hongli Gong, Chi-Yao Hsueh, Liang Zhou
Journal of Oral Microbiology.2022;[Epub] CrossRef - Oral microbiota in oropharyngeal cancers: Friend or foe?
Riccardo Nocini, Lorenzo Lo Muzio, Davide Gibellini, Giovanni Malerba, Michele Milella, Salvatore Chirumbolo, Nicoletta Zerman
Frontiers in Oncology.2022;[Epub] CrossRef - Oropharynx microbiota transitions in hypopharyngeal carcinoma treatment of induced chemotherapy followed by surgery
Hui-Ching Lau, Chi-Yao Hsueh, Hongli Gong, Ji Sun, Hui-Ying Huang, Ming Zhang, Liang Zhou
BMC Microbiology.2021;[Epub] CrossRef - The Role of Bacterial and Fungal Human Respiratory Microbiota in COVID‐19 Patients
Saber Soltani, Armin Zakeri, Milad Zandi, Mina Mobini Kesheh, Alireza Tabibzadeh, Mahsa Dastranj, Samireh Faramarzi, Mojtaba Didehdar, Hossein Hafezi, Parastoo Hosseini, Abbas Farahani, Cassiano Felippe Gonçalves-de-Albuquerque
BioMed Research International.2021;[Epub] CrossRef - Selective Bacterial Colonization of the Murine Larynx in a Gnotobiotic Model
Ran An, Madhu Gowda, Federico E. Rey, Susan L. Thibeault
Frontiers in Microbiology.2020;[Epub] CrossRef - Throat Microbial Community Structure and Functional Changes in Postsurgery Laryngeal Carcinoma Patients
Chi-Yao Hsueh, Hongli Gong, Ning Cong, Ji Sun, Hui-Ching Lau, Yang Guo, Qiang Huang, Xiaohui Yuan, Ming Zhang, Lei Tao, Liang Zhou, Harold L. Drake
Applied and Environmental Microbiology.2020;[Epub] CrossRef - Fusobacterium spp. target human CEACAM1 via the trimeric autotransporter adhesin CbpF
Matthew L. Brewer, David Dymock, R. Leo Brady, Bernhard B. Singer, Mumtaz Virji, Darryl J. Hill
Journal of Oral Microbiology.2019; 11(1): 1565043. CrossRef - Quality and metagenomic evaluation of a novel functional beverage produced from soy whey using water kefir grains
Chuanhai Tu, Fidelis Azi, Jin Huang, Xiao Xu, Guangliang Xing, Mingsheng Dong
LWT.2019; 113: 108258. CrossRef - Potential role of microbiome in oncogenesis, outcome prediction and therapeutic targeting for head and neck cancer
Ester Orlandi, Nicola Alessandro Iacovelli, Vincenzo Tombolini, Tiziana Rancati, Antonella Polimeni, Loris De Cecco, Riccardo Valdagni, Francesca De Felice
Oral Oncology.2019; 99: 104453. CrossRef
|
MSK
