- Possible Translocation of Periodontal Pathogens into the Lymph Nodes Draining the Oral Cavity
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G. Amodini Rajakaruna , Makoto Umeda , Keisuke Uchida , Asuka Furukawa , Bae Yuan , Yoshimi Suzuki , Ebe Noriko , Yuichi Izumi , Yoshinobu Eishi
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J. Microbiol. 2012;50(5):827-836. Published online November 4, 2012
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DOI: https://doi.org/10.1007/s12275-012-2030-8
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Numerous publications have reported the presence of periodontopathogenic bacteria in peripheral and central vascular lesions. However, it is unclear how this bacterial translocation occurs. The objective of this study was to investigate whether periodontopathic bacteria are translocated to lymph nodes proximal to the oral cavity. Obtaining lymph node samples is not ethically feasible unless they are excised as part of the surgical management of patients with cancer. This study analyzed formalin-fixed and paraffin-embedded lymph nodes, histologically negative for cancer cell invasion, that were excised from 66 patients with histories of head and neck cancer. Real-time PCR was performed to amplify the 16S ribosomal DNA fragments from Porphyromonas gingivalis, Treponema denticola, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Prevotella intermedia. The relationship between bacterial detection and cancer severity, gender, and the use of anti-cancer therapy was examined by Fisher’s exact test. P. gingivalis, T. forsythia, and P. intermedia were present in 17%, 8%, and 8% of the samples of submandibular and submental lymph nodes, respectively. There were no significant relationships between bacterial detection and the cancer disease status, patient gender or use of anticancer therapy. According to these data, it appears that the translocation of periodontopathic bacteria may occur via lymphatic drainage, irrespective of the cancer disease status, gender or anticancer therapy.
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Qijun Ruan, Peng Guan, Weijuan Qi, Jiatong Li, Mengying Xi, Limin Xiao, Sulan Zhong, Dandan Ma, Jia Ni
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Supportive Care in Cancer.2022; 30(4): 3337. CrossRef - 術前口腔環境の適正化
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The Japanese Journal of SURGICAL METABOLISM and NUTRITION.2021; 55(5): 166. CrossRef - Periodontal disease and cancer: Epidemiologic studies and possible mechanisms
Ngozi Nwizu, Jean Wactawski‐Wende, Robert J. Genco
Periodontology 2000.2020; 83(1): 213. CrossRef - Unculturable and culturable periodontal-related bacteria are associated with periodontal inflammation during pregnancy and with preterm low birth weight delivery
Changchang Ye, Zhongyi Xia, Jing Tang, Thatawee Khemwong, Yvonne Kapila, Ryutaro Kuraji, Ping Huang, Yafei Wu, Hiroaki Kobayashi
Scientific Reports.2020;[Epub] CrossRef - How the evolving epidemics of opioid misuse and HIV infection may be changing the risk of oral sexually transmitted infection risk through microbiome modulation
Wiley D. Jenkins, Lauren B. Beach, Christofer Rodriguez, Lesli Choat
Critical Reviews in Microbiology.2020; 46(1): 49. CrossRef - The periodontopathic bacteria in placenta, saliva and subgingival plaque of threatened preterm labor and preterm low birth weight cases: a longitudinal study in Japanese pregnant women
Changchang Ye, Sayaka Katagiri, Naoyuki Miyasaka, Hiroaki Kobayashi, Thatawee Khemwong, Toshiyuki Nagasawa, Yuichi Izumi
Clinical Oral Investigations.2020; 24(12): 4261. CrossRef - Fretibacterium sp. human oral taxon 360 is a novel biomarker for periodontitis screening in the Japanese population
Thatawee Khemwong, Hiroaki Kobayashi, Yuichi Ikeda, Takanori Matsuura, Takeaki Sudo, Chihiro Kano, Ryo Mikami, Yuichi Izumi, David M. Ojcius
PLOS ONE.2019; 14(6): e0218266. CrossRef - Eubacterium saphenum as a Novel Bacterial Biomarker for Periodontitis Screening
Thatawee KHEMWONG, Hiroaki KOBAYASHI, Yuichi IKEDA, Takeaki SUDO, Chihiro KANO, Takanori MATSUURA, Yuichi IZUMI
THE JOURNAL OF THE STOMATOLOGICAL SOCIETY,JAPAN.2018; 85(2): 62. CrossRef - Oral hygiene might prevent cancer
Oscar J. Cordero, Rubén Varela-Calviño
Heliyon.2018; 4(10): e00879. CrossRef - Localization and density of Porphyromonas gingivalis and Tannerella forsythia in gingival and subgingival granulation tissues affected by chronic or aggressive periodontitis
G. Amodini Rajakaruna, Mariko Negi, Keisuke Uchida, Masaki Sekine, Asuka Furukawa, Takashi Ito, Daisuke Kobayashi, Yoshimi Suzuki, Takumi Akashi, Makoto Umeda, Walter Meinzer, Yuichi Izumi, Yoshinobu Eishi
Scientific Reports.2018;[Epub] CrossRef - Periodontal Disease and Incident Cancer Risk among Postmenopausal Women: Results from the Women's Health Initiative Observational Cohort
Ngozi N. Nwizu, James R. Marshall, Kirsten Moysich, Robert J. Genco, Kathleen M. Hovey, Xiaodan Mai, Michael J. LaMonte, Jo L. Freudenheim, Jean Wactawski-Wende
Cancer Epidemiology, Biomarkers & Prevention.2017; 26(8): 1255. CrossRef - 周術期口腔ケアによる消化器外科術後の感染性合併症に対する予防効果
The Japanese Journal of SURGICAL METABOLISM and NUTRITION.2017; 51(4): 165. CrossRef - The oral cavity microbiota: between health, oral disease, and cancers of the aerodigestive tract
Pierre Le Bars, Sébastien Matamoros, Emmanuel Montassier, Françoise Le Vacon, Gilles Potel, Assem Soueidan, Fabienne Jordana, Marie-France de La Cochetière
Canadian Journal of Microbiology.2017; 63(6): 475. CrossRef - Gingipain‐dependent augmentation by Porphyromonas gingivalis of phagocytosis of Tannerella forsythia
Y.‐J. Jung, H.‐K. Jun, B.‐K. Choi
Molecular Oral Microbiology.2016; 31(6): 457. CrossRef - Inverse Association of Plasma IgG Antibody to Aggregatibacter actinomycetemcomitans and High C-Reactive Protein Levels in Patients with Metabolic Syndrome and Periodontitis
Supanee Thanakun, Suchaya Pornprasertsuk-Damrongsri, Misa Gokyu, Hiroaki Kobayashi, Yuichi Izumi, Özlem Yilmaz
PLOS ONE.2016; 11(2): e0148638. CrossRef - The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity
Özlem Yilmaz, Kyu Lim Lee
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Clinical Pediatrics.2014; 53(11): 1027. CrossRef - Looking in the Porphyromonas gingivalis cabinet of curiosities: the microbium, the host and cancer association
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Molecular Oral Microbiology.2014; 29(2): 55. CrossRef
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