- Whole-genome sequencing analysis of Shiga toxin-producing Escherichia coli O22:H8 isolated from cattle prediction pathogenesis and colonization factors and position in STEC universe phylogeny
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Wanderson Marques Da Silva , Mariano Larzabal , Flavia Figueira Aburjaile , Nahuel Riviere , Luisina Martorelli , James Bono , Ariel Amadio , Angel Cataldi
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J. Microbiol. 2022;60(7):689-704. Published online June 22, 2022
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DOI: https://doi.org/10.1007/s12275-022-1616-z
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 Abstract
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Shiga toxin-producing Escherichia coli (STEC) is a foodborne
pathogen capable of causing illness in humans. In a previous
study, our group showed that a STEC isolate belonging to
O22:H8 serotype (strain 154) can interfere with STEC O157:H7
colonization both in vitro and in vivo. Using whole-genome
sequencing and genomic comparative, we predicted a subset
of genes acquired by O22:H8 strain 154 through horizontal
gene transfer that might be responsible for the phenotype
previously described by our group. Among them were identified
genes related to the pathogenesis of non-LEE (locus of
enterocyte effacement) STEC, specific metabolic processes,
antibiotic resistance and genes encoding for the T6SS-1 that
is related to inter-bacterial competition. In addition, we showed
that this strain carries stx1c and stx2dact, a mucus-inducible
variant. The results obtained in this study provide insights
into STEC genomic plasticity and the importance of genomic
islands in the adaptation and pathogenesis of this
pathogen.
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Citations
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